Fatal respiratory distress syndrome due to coronavirus infection in a child with severe combined immunodeficiency

Szczawińska-Popłonyk, Aleksandra; Jończyk‐Potoczna, Katarzyna; Bręborowicz, Anna; Bartkowska-Śniatkowska, Alicja; Figlerowicz, Magdalena

doi:10.1111/irv.12059

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…HCoV has been described as a possible etiology of severe pneumonia in immunocompromised hosts [64][65][66][67]. Data are limited for this high-risk population and particularly are lacking in pediatric hematopoietic cell transplantation (HCT) recipients [68].…”

Section: Immunocompromised Hostmentioning

confidence: 99%

What’s New With the Old Coronaviruses?

Ogimi

Kim

Martin

et al. 2020

Journal of the Pediatric Infectious Diseases Society

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Coronaviruses contribute to the burden of respiratory diseases in children, frequently manifesting in upper respiratory symptoms considered to be part of the "common cold. " Recent epidemics of novel coronaviruses recognized in the 21st century have highlighted issues of zoonotic origins of transmissible respiratory viruses and potential transmission, disease, and mortality related to these viruses. In this review, we discuss what is known about the virology, epidemiology, and disease associated with pediatric infection with the common community-acquired human coronaviruses, including species 229E, OC43, NL63, and HKU1, and the coronaviruses responsible for past world-wide epidemics due to severe acute respiratory syndrome and Middle East respiratory syndrome coronavirus.

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Section: Immunocompromised Hostmentioning

confidence: 99%

What’s New With the Old Coronaviruses?

Ogimi

Kim

Martin

et al. 2020

Journal of the Pediatric Infectious Diseases Society

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“…It is worth noting that administration of live attenuated vaccines against Mycobacterium tuberculosis in all children studied as well as against measles, mumps and rubella in the two patients, did not lead to vaccine-associated adverse effects in any of them despite T-cell lymphopenia, posing a high risk of complications. In as many as four of all five of the children studied, we found specific etiology, associated with CMV infection and in one child we documented an hCoV infection [ 4 ]. Certainly, such a small study group of children with SCID as a result of the proportional frequency of this primary immunodeficiency in the pediatric population [ 5 ], estimated at about 7% of all PIDs [ 6 ] was under investigation, is the major limitation of this review.…”

Section: Discussionmentioning

confidence: 99%

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

Szczawińska-Popłonyk¹,

Jończyk‐Potoczna²,

Ossowska³

et al. 2014

cejoi

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Severe combined immunodeficiency (SCID) is characterized by the absence of functional T lymphocytes and impairment of adaptive immunity. While heterogeneity of the genetic background in SCID leads to the variability of immune phenotypes, most of affected newborns appear healthy but within the first few months they develop life-threatening opportunistic respiratory or gastrointestinal tract infections. The objective of the study was to define the presenting features and etiology of infections in children with SCID. We retrospectively reviewed five children in whom the diagnosis of SCID had been established in our pediatric immunology clinic over the last 10-year period. A viral respiratory tract infection was the first manifestation of SCID in all the children studied. Cytomegalovirus (CMV) pneumonia was recognized in as many as 4 cases and coronavirus pulmonary infection was diagnosed in one case, whereas Pneumocystis jiroveci was identified as a co-pathogen in one CMV-infected patient. Severe combined immunodeficiency is a pediatric emergency condition and given the significant impact of pulmonary CMV infection in SCID children, establishing an accurate etiological diagnosis is of essential importance in instituting the specific treatment and improving the outcome.

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“…In this context, altered immune responses, such as those caused by primary immunodeficiencies (PIDs), may be important in disease progression, where at least one case of death has already been reported during coronavirus infection ( Szczawinska-Poplonyk et al, 2013 ). More severe viral infections have been associated with the presence of PID ( Dropulic and Cohen, 2011 ), which constitute a group of more than 350 rare diseases that together have a considerable prevalence ( McCusker et al, 2018 ).…”

Section: Genetics Of the Human Host In Sars-cov-2 Infectionmentioning

confidence: 99%

The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic

et al. 2022

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The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to the death of millions of people worldwide and thousands more infected individuals developed sequelae due to the disease of the new coronavirus of 2019 (COVID-19). The development of several studies has contributed to the knowledge about the evolution of SARS-CoV2 infection and the disease to more severe forms. Despite this information being debated in the scientific literature, many mechanisms still need to be better understood in order to control the spread of the virus and treat clinical cases of COVID-19. In this article, we carried out an extensive literature review in order to bring together, in a single article, the biological, social, genetic, diagnostic, therapeutic, immunization, and even socioeconomic aspects that impact the SAR-CoV-2 pandemic. This information gathered in this article will enable a broad and consistent reading of the main aspects related to the current pandemic.

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Fatal respiratory distress syndrome due to coronavirus infection in a child with severe combined immunodeficiency

Cited by 6 publications

References 9 publications

What’s New With the Old Coronaviruses?

What’s New With the Old Coronaviruses?

Clinical immunology Cytomegalovirus pneumonia as the first manifestation of severe combined immunodeficiency

The Complexity of SARS-CoV-2 Infection and the COVID-19 Pandemic

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