Fatal outcome in a patient with autoimmune hemolytic anemia associated with an IgM bithermic anti‐ITP

Abstract

Serologic studies are consistent with our patient's having a single IgM cold autoantibody with IT and P specificities (anti-ITP) and requiring both specificities on the same RBC to permit maximal antibody expression.

P1PK, Globoside, and FORS Blood Group Systems, Plus Some Other Related Blood Groups

“…Anti -I T P1 was identifi ed in a Melanesian [164] . Bithermic anti -I T P behaved as anti -I T , apart from its failure to agglutinate p cells [165] . Anti -IP, together with anti -IP1, was found in a patient with unusual P and I antigens [166] .…”

I and i Antigens, and Cold Agglutination

“…An antibody reacting only weakly with cord and adult i cells, and not at all with p cells, was named anti -IP [153] . Anti -I T P was responsible for fatal AIHA [154] .…”

Paroxysmal cold hemoglobinuria due to an IgA Donath–Landsteiner antibody

“…Although PCH is classically associated with D‐L autoantibodies of the IgG isotype, there have been rare case reports of IgM D‐L autoantibodies but none involving IgA …”