1987
DOI: 10.1111/j.1524-4725.1987.tb00942.x
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Fatal Outcome in a Metatypical, Giant, “Horrifying” Basal Cell Carcinoma

Abstract: Mutilating, horrifying, aggressive basal cell carcinoma (BCC) is a rare cutaneous neoplasm. We report a case of mutilating BCC of the face and its peculiar histologic features. The primary lesion, before therapy, demonstrated typical BCC in association with lobules of metatypical cells. The recurrent BCC, after radiation therapy, had a metatypical pattern. We believe that the metatypical BCC is a potentially aggressive lesion. It is essential for this tumor to be recognized early and treated surgically.

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Cited by 18 publications
(6 citation statements)
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“…It has been characterized as a variant of basal cell carcinoma (BCC), which differentiates into squamous cell carcinoma (SCC) by Burston and Clay 2 . Like SCC, it is more locally invasive and more likely to metastasize than other forms of BCC 3 . Opinions vary among pathologists as to what constitutes a “basosquamous” carcinoma.…”
mentioning
confidence: 99%
“…It has been characterized as a variant of basal cell carcinoma (BCC), which differentiates into squamous cell carcinoma (SCC) by Burston and Clay 2 . Like SCC, it is more locally invasive and more likely to metastasize than other forms of BCC 3 . Opinions vary among pathologists as to what constitutes a “basosquamous” carcinoma.…”
mentioning
confidence: 99%
“…In the literature, so-called giant basal cell carcinomas are infrequently reported and are associated with poorer prognosis more often than smaller lesions [1,2,3,4,5,6,7,8,9,10,11,12]. Frequently they are associated with multiple recurrences of previously treated smaller basal cell carcinomas, aggressive histological patterns, and a history of radiation exposure or patient neglect [1,2,3,4,5,6,7,8,9,10,11,12].…”
Section: Discussionmentioning
confidence: 98%
“…Most are small (<1 cm in diameter), well-defined lesions that are easily diagnosed, treated, and cured by a variety of methods [4]. In a small subset of patients, giant basal cell carcinomas (>5 cm in diameter, T 3 ) are capable of extensive local invasion [1,2,3,4,5,6,7,8,9,10,11,12].…”
Section: Discussionmentioning
confidence: 99%
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“…- ADAMS, 1973;BIANCHINI & WOLTER, 1984; 1998), registrando uma evoluc;ao especialmente desfavoravel nestas situac;6es.…”
Section: Variaveis Clinicasunclassified