Fatal Measles Pneumonia in an Immunocompetent Patient--Case Report

Chapnick, Edward K.; Gradon, Jeremy D.; Kim, Yong doo; Narvios, Aida; Gerard, Perry; Till, Michele; Sepkowitz, Douglas

doi:10.1093/clinids/15.2.377

Cited by 13 publications

(11 citation statements)

References 3 publications

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“…Chapnick et al 9 described one such case in a 32-year-old patient suffering from bipolar disease, which was diagnosed by autopsy. A case of fatal intractable ARDS without the typical measles rash in a 29-year-old immunocompetent female patient has been reported by Lupo et al 10.…”

Section: Discussionmentioning

confidence: 99%

Fatal measles presenting as acute respiratory distress syndrome in an immunocompetent adult

et al. 2014

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SUMMARYFatal measles is known to occur among immunocompromised adults. We report a rare case of an immunocompetent non-pregnant young lady who suffered from fatal acute respiratory distress syndrome due to measles. Physicians must be vigilant to this deadly presentation of measles even in immunocompetent individuals. We emphasise the inadequacies of vaccination programmes in India reflected not only by the existing high measles-related childhood mortalities, but also an emerging rise in deaths among adults. BACKGROUND

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Section: Discussionmentioning

confidence: 99%

Fatal measles presenting as acute respiratory distress syndrome in an immunocompetent adult

et al. 2014

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“…Mortality increases with young age (5), malnutrition (6), and other immune-suppressed statuses. Although pneumonia is a relatively benign complication in previously healthy adolescents, there are reports of fatalities due to measles pneumonia among such cases (2,3). Pneumonia is reported to complicate 3 to 50% of measles cases (7,8).…”

Section: Case2mentioning

confidence: 99%

“…In developing countries, measles remains a disease with high morbidity and an important cause of childhood mortality (1). Pneumonia caused by the measles virus itself is an uncommon complication which maydevelop into severe respiratory failure (2)(3)(4). Wereport two cases of measles that developed into severe bilateral diffuse pneumonia.…”

Section: Introductionmentioning

confidence: 99%

Familial Cases of Severe Measles Pneumonia.

et al. 2000

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Wereport two cases of severe measles pneumonia.Patient 1, a 17-year-old boy who contracted measles in the acute phase of infectious mononucleosis caused by EpsteinBarr virus (EBV), transmitted the disease to patient 2, his father. Both patients presented severe pneumonia with bilateral diffuse micronodular shadows. Diagnoses were established in both patients by antibody titers for measles and reverse transcriptase-polymerase chain reaction (RT-PCR) of blood and throat swab. Multinucleated giant cells with intranuclear inclusion bodies were revealed in the transbronchial lung biopsy (TBLB) specimen of patient 2. Both patients recovered with pulse steroid therapy.

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“…Deaths from measles with pneumonia or ARDS but without rash have been reported but mostly in patients with deficient cell-mediated immunity ( 2 – 6 ). Despite all our testing, we found no indications of an underlying immunosuppressive disease in this patient; however, we cannot categorically rule out this possibility, especially that of a primary immunodeficiency.…”

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confidence: 99%