FATAL INFECTIONS BY HqMOLYTIC STREPTOCOCCUS GROUP B

Fry, R. M.

doi:10.1016/s0140-6736(00)93202-1

Cited by 180 publications

(80 citation statements)

References 5 publications

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“…at 30-min intervals using an automated system (AutoAnalyzer; Technicon Instrument Corp., Tarrytown, NY) by a modified Biuret method (12). Arterial blood gases were measured every 30 Group B /3-hemolytic Streptococci have been implicated in fatal min in a pH-Blood Gas Analyzer (Model 213; Instrumentation human disease since 1938 (15) and are currently the most frequent Laboratory, Inc., Lexington, MA), and rectal temperature was pathogens associated with neonatal infectious mortality (19,20), monitored continuously with a YSI tele-thermometer (Yellow causing one death per 1000 live births (14). In 1973, Franciosi et Springs Instrument Co., Yellow Springs, OH).…”

Section: Methodsmentioning

confidence: 99%

Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep

et al. 1981

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Section: Methodsmentioning

confidence: 99%

Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep

et al. 1981

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“…This bacterial pathogen was described initially in 1887 as an animal pathogen (11). Human infections caused by this bacterium were reported in the 1930s (12), and since the 1970s it has been recognized as the leading neonatal pathogen in the developed world (13). Analyses of MLST data from different geographic regions showed that isolates infecting and colonizing neonates cluster mainly in five clonal complexes (CCs), of which CC17 is a major hyperinvasive neonatal clone (14).…”

mentioning

confidence: 99%

Shaping a bacterial genome by large chromosomal replacements, the evolutionary history of Streptococcus agalactiae

Brochet

Rusniok

Couvé

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

128

121

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Bacterial populations are subject to complex processes of diversification that involve mutation and horizontal DNA transfer mediated by transformation, transduction, or conjugation. Tracing the evolutionary events leading to genetic changes allows us to infer the history of a microbe. Here, we combine experimental and in silico approaches to explore the forces that drive the genome dynamics of Streptococcus agalactiae, the leading cause of neonatal infections. We demonstrate that large DNA segments of up to 334 kb of the chromosome of S. agalactiae can be transferred through conjugation from multiple initiation sites. Consistently, a genome-wide map analysis of nucleotide polymorphisms among eight human isolates demonstrated that each chromosome is a mosaic of large chromosomal fragments from different ancestors suggesting that large DNA exchanges have contributed to the genome dynamics in the natural population. The analysis of the resulting genetic flux led us to propose a model for the evolutionary history of this species in which clonal complexes of clinical importance derived from a single clone that evolved by exchanging large chromosomal regions with more distantly related strains. The emergence of this clone could be linked to selective sweeps associated with the reduction of genetic diversity in three regions within a large panel of human isolates. Up to now sex in bacteria has been assumed to involve mainly small regions; our results define S. agalactiae as an alternative paradigm in the study of bacterial evolution.

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“…Streptococcus agalactiae, the species designation of GBS (5), was initially described in 1887 as an animal pathogen causing bovine mastitis (28). Human infections caused by this bacterium were only reported 50 years later, in the 1930s (13,16,29). Neonatal disease, though, was rarely reported.…”

mentioning

confidence: 99%

Hyperinvasive Neonatal Group B Streptococcus Has Arisen from a Bovine Ancestor

et al. 2004

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The genetic relatedness and evolutionary relationships between group B streptococcus (GBS) isolates from humans and those from bovines were investigated by phylogenetic analysis of multilocus sequence typing data. The collection of isolates consisted of 111 GBS isolates from cows with mastitis and a diverse global collection of GBS isolates from patients with invasive disease (n ‫؍‬ 83) and carriers (n ‫؍‬ 69). Cluster analysis showed that the majority of the bovine isolates (93%) grouped into one phylogenetic cluster. The human isolates showed greater diversity and clustered separately from the bovine population. However, the homogeneous human sequence type 17 (ST-17) complex, known to be significantly associated with invasive neonatal disease, was the only human lineage found to be clustered within the bovine population and was distinct from all the other human lineages. Split decomposition analysis revealed that the human isolate ST-17 complex, the major hyperinvasive neonatal clone, has recently arisen from a bovine lineage.

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FATAL INFECTIONS BY HqMOLYTIC STREPTOCOCCUS GROUP B

Cited by 180 publications

References 5 publications

Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep

Studies on Group B β-Hemolytic Streptococcus. II. Effects on Pulmonary Hemodynamics and Vascular Permeability in Unanesthetized Sheep

Shaping a bacterial genome by large chromosomal replacements, the evolutionary history of Streptococcus agalactiae

Hyperinvasive Neonatal Group B Streptococcus Has Arisen from a Bovine Ancestor

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