Fatal <i><scp>C</scp>leistanthus collinus</i> Toxicity: A Case Report and Review of Literature

Das, Siddhartha; Hamide, Abdoul; Mohanty, Manoj Kumar; Muthusamy, R.

doi:10.1111/1556-4029.12519

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…Cleistanthus collinus [Family: Phyllanthaceae] leaves are notorious for being commonly used as a suicidal agent in southern states of India with many case reports describing the same. [1][2][3][4] The multisystem involvement and electrolyte disturbances (specifically hypokalemia) are the most common features of toxicity. [5][6][7] Some patients have developed severe hypotension not reversed even with strong vasoactive agents.…”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10][11][12] Most toxic manifestations of Cleistanthus collinus poisoning have been successfully linked to cleistanthins A and B, but what has spurred the interest in these novel compounds is their cytotoxic potential. 1,4 In vitro and in vivo data suggest promising anticancer, antimicrobial and larvicidal activities as well. [13][14][15][16][17] However, hypotension caused in patients of Cleistanthus collinus poisoning is concerning.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Cleistanthins A and B on the Isolated Aorta of Guinea Pig

Sahoo¹,

Girish²,

Raveendran³

2021

JYP

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Objectives: Cleistanthins A and B are the active compounds isolated from Cleistanthus collinus leaves. The hypotensive activity of both cleistanthins A and B and the leaf extract has been previously demonstrated, but the exact mechanism of action is not clear. So, this study was designed to test the vasorelaxant property of cleistanthins A and B and delineate its mechanism of action. Methods: Variable force transducers were used to record the force of contraction from the aortic rings of 24 male guinea pigs. The effect of cleistanthin A, cleistanthin B, prazosin and vehicle on the phenylephrine-induced contractions and potassium chloride-induced contractions was demonstrated and compared. Results: Cleistanthin B inhibited the phenylephrine-induced contractions in a dose-dependent manner and demonstrated potency (pIC 50 = 6.8 ± 1.06) comparable to prazosin (pIC 50 = 5.7 ± 0.7). Cleistanthin A potency could not be calculated. Both cleistanthin A (4 µg) and cleistanthin B (40 µg) caused a reduction of the maximal response of phenylephrine demonstrating irreversible blockade. They did not affect the potassium chloride-induced contractions. This illustrates that cleistanthins A and B are noncompetitive α 1 adrenergic blockers and the potency of cleistanthin B is comparable to prazosin. Conclusion: Both cleistanthins A and B have vasodilatory action on guinea pig aorta. The action is through non-competitive α 1 adrenergic receptor inhibition and calcium channel blockade does not contribute to the inhibition.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Cleistanthins A and B on the Isolated Aorta of Guinea Pig

Sahoo¹,

Girish²,

Raveendran³

2021

JYP

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The Chemistry and biology of the plant poisons and their forensic significance

Patil,

Paikrao,

Patil

2023

Studies in Natural Products Chemistry

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Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice

Thummar

Parasuraman

Basu

et al. 2016

Journal of Traditional and Complementary Medicine

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To evaluate the in vivo antitumor activity of cleistanthin B in Ehrlich's ascites carcinoma (EAC) and Dalton's ascites lymphoma (DAL) cell lines induced malignant ascites mouse models and DAL cell line induced solid tumor mouse model. All animals were injected with 2 × 106 EAC/DAL cells i.p./s.c. to induce malignant ascites and solid tumor and treated with 5-fluorouracil (5-FU) 20 mg/kg or cleistanthin B for 10 days. Cleistanthin B was given at three doses viz. 25, 50 and 100 mg/kg. The percentage increase in life span and the overall survival in malignant ascites animals and the tumor volume in solid tumor animals were measured. The haematological parameters were assessed in all animals before and 2 weeks after the treatment. Cleistanthin B 50 mg/kg and 5-FU significantly prolonged the life span (>25%) of malignant ascites tumor bearing animals. The overall survival was significantly improved by both. Only cleistanthin B 50 mg/kg significantly reduced the elevated WBC counts in EAC tumor bearing animals. Both 5-FU and cleistanthin B 50 mg/kg reversed the malignancy induced increase in neutrophils and platelet counts and decrease in lymphocyte counts but not to the normal range. Only 5-FU significantly reduced the solid tumor volume. None of the three doses of cleistanthin B was effective against the solid tumor. Cleistanthin B has antitumor activity against EAC and DAL tumor mice but it is not as effective as 5-FU. At 50 mg/kg dose cleistanthin B exerts significant antitumor activity compared to 25 and 100 mg/kg dose. Its effect on WBC count is higher and advantageous when compared to 5-FU. But cleistanthin B in the doses used is not effective against solid tumor.

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Fatal Cleistanthus collinus Toxicity: A Case Report and Review of Literature

Cited by 3 publications

References 18 publications

Effect of Cleistanthins A and B on the Isolated Aorta of Guinea Pig

Effect of Cleistanthins A and B on the Isolated Aorta of Guinea Pig

The Chemistry and biology of the plant poisons and their forensic significance

Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice

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