Fatal human herpes virus 6B myocarditis: Postmortem diagnosis of HHV-6B based on CD134+ T-cell tropism

Yamada, Atsushi; Takeichi, Toshiaki; Kiryu, Kyoka; Takashino, Satoshi; Yoshida, Masaki; Kitamura, Osamu

doi:10.1016/j.legalmed.2021.102007

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…As to triggers, various infectious and non-infectious etiologies have been implicated in the causation of myocarditis, but the common suspects are viruses. In contrast to the earlier prevailing notion that enteroviruses and adenoviruses were found to be associated with viral myocarditis in North America and Europe, respectively, recent data suggest other viruses, such as human herpesvirus 6 and parvovirus B19, as well as coronaviruses [ 70 ], are increasingly being reported [ 71 ]. However, the major challenge is being able to demonstrate infectious virions in patients with myocarditis/DCM at the time of clinical presentation when viruses would have done the damage and be cleared from the bloodstream of affected patients.…”

Section: Virus Infection and Disease Pathogenesismentioning

confidence: 94%

Vaccines against Group B Coxsackieviruses and Their Importance

et al. 2023

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The group B coxsackieviruses (CVBs) exist in six serotypes (CVB1 to CVB6). Disease associations have been reported for most serotypes, and multiple serotypes can cause similar diseases. For example, CVB1, CVB3, and CVB5 are generally implicated in the causation of myocarditis, whereas CVB1 and CVB4 could accelerate the development of type 1 diabetes (T1D). Yet, no vaccines against these viruses are currently available. In this review, we have analyzed the attributes of experimentally tested vaccines and discussed their merits and demerits or limitations, as well as their impact in preventing infections, most importantly myocarditis and T1D.

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Section: Virus Infection and Disease Pathogenesismentioning

confidence: 94%