Fatal HBoV-1 infection in adult female cystic fibrosis patient

Severe Human Bocavirus–Associated Pneumonia in Adults at a Referral Hospital, Seoul, South Korea

“…Information on severe HBoV-associated pneumonia in adults is limited. Five cases of severe HBoV-associated pneumonia have been reported to date ( 8 – 12 ), which included 3 cases from the same facility in Germany ( 9 , 10 , 12 ). Of the 5 patients, 3 had hematologic malignancy and 1 had cystic fibrosis.…”

“…It can also be associated with the acute exacerbation of chronic obstructive pulmonary disease (7). Recently, a few case reports have shown that HBoV can be associated with life-threatening pneumonia (8)(9)(10)(11)(12). However, severe HBoV-associated pneumonia has not been reported in a case series, and little is known about the characteristics of HBoV-associated pneumonia in critically ill adult patients.…”

Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

“…In addition, both Sadeghi et al [19] and Krakau et al [20] described immunocompromised adult patients suffering from an advanced myelodysplastic syndrome with severe HBoV1 pneumonia with fatal outcome. Further fatal cases associated with HBoV1 infection were described in an adult and a pediatric patient with underlying lung diseases [21,22]. The need for ventilator support for four months reflecting the extensive lung damage is perfectly explained by the severe ARDS leading to lung fibrosis, impaired gas exchange and eventually death of the patient.…”

High-dose glucocorticoid treatment of near-fatal bocavirus lung infection results in rapid recovery

“…Human bocavirus (HBoV), which belongs to Parvoviridae , is a well-defined pathogen of respiratory infections, particularly in young children [ 1 ]. In contrast, the frequency of HBoV infections in adults with respiratory symptoms is virtually unknown and its causative role in respiratory failure is debated [ 1 , 2 ]. Furthermore, the observation that dexamethasone is beneficial in COVID-19 patients with respiratory failure requiring respiratory support has gained great interest [ 3 ].…”