Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

Tabatabai, Julia; Fakhiri, Julia; Meyburg, Jochen; Linse, Kai-Philipp; Xu, Man; Söderlund‐Venermo, Maria; Grimm, Dirk; Schnitzler, Paul

doi:10.1097/inf.0000000000002354

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…However, although most HBoV infections mostly have a benign course, the infected children (also the mono-infected cases) could have a severe disease course at a not-marginal rate, requiring PICU admission and invasive ventilation [ 20 , 21 , 81 ]. Of note, several children with a fatal outcome have also been described as having a single infection [ 71 , 75 , 76 , 77 ]. These findings support the hypothesis that HBoV may be a causative agent of severe RTIs and pneumonia and not a simple passenger.…”

Section: Discussionmentioning

confidence: 99%

“…Liao et al reviewed 12 children with HBoV1-related severe respiratory infection admitted to the ICU, including a case described by himself [ 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 ]. The diagnoses were respiratory failure (five cases), ARDS (five cases), bronchiolitis, atelectasis, and status asthma, suggesting that severe HBoV infection often leads to respiratory failure and ARDS [ 72 , 77 ].…”

Section: Clinical Featuresmentioning

confidence: 99%

“…There have, however, been cases of life-threatening diseases caused by a mono bocavirus infection [ 5 , 72 , 93 ] and several fatal cases in infants with lower RTIs [ 71 , 75 , 76 ]. Similarly, Colazo-Salbetti found pneumonia was more frequent in mono-infections than in co-infections [ 94 ]; the same results were obtained by Petrarca et al who found HBoV detected alone in severe cases and all cases of pneumonia [ 19 ].…”

Section: Co-infectionsmentioning

confidence: 99%

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Human Bocavirus in Childhood: A True Respiratory Pathogen or a “Passenger” Virus? A Comprehensive Review

Trapani,

Caporizzi,

Ricci

et al. 2023

Microorganisms

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Recently, human bocavirus (HBoV) has appeared as an emerging pathogen, with an increasing number of cases reported worldwide. HBoV is mainly associated with upper and lower respiratory tract infections in adults and children. However, its role as a respiratory pathogen is still not fully understood. It has been reported both as a co-infectious agent (predominantly with respiratory syncytial virus, rhinovirus, parainfluenza viruses, and adenovirus), and as an isolated viral pathogen during respiratory tract infections. It has also been found in asymptomatic subjects. The authors review the available literature on the epidemiology of HBoV, the underlying risk factors associated with infection, the virus’s transmission, and its pathogenicity as a single pathogen and in co-infections, as well as the current hypothesis about the host’s immune response. An update on different HBoV detection methods is provided, including the use of quantitative single or multiplex molecular methods (screening panels) on nasopharyngeal swabs or respiratory secretions, tissue biopsies, serum tests, and metagenomic next-generations sequencing in serum and respiratory secretions. The clinical features of infection, mainly regarding the respiratory tract but also, though rarely, the gastrointestinal one, are extensively described. Furthermore, a specific focus is dedicated to severe HBoV infections requiring hospitalization, oxygen therapy, and/or intensive care in the pediatric age; rare fatal cases have also been reported. Data on tissue viral persistence, reactivation, and reinfection are evaluated. A comparison of the clinical characteristics of single infection and viral or bacterial co-infections with high or low HBoV rates is carried out to establish the real burden of HBoV disease in the pediatric population.

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Section: Discussionmentioning

confidence: 99%

Section: Clinical Featuresmentioning

confidence: 99%

Section: Co-infectionsmentioning

confidence: 99%

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Human Bocavirus in Childhood: A True Respiratory Pathogen or a “Passenger” Virus? A Comprehensive Review

Trapani,

Caporizzi,

Ricci

et al. 2023

Microorganisms

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“…Furthermore, diarrhea and acute otitis media are often reported in association with HBoV1 infection (1,5,6). HBoV1 has with reliable diagnostic means been shown to also cause severe and life-threatening RTIs in children, necessitating intensive care with mechanical ventilation (104)(105)(106)(107)(108)(109)(110)(111). Distinctive signs of pneumonia, with interstitial infiltrates in chest X-rays, hyperinflation, and atelectasis, as well as hypoxia and tachypnea, are seen in HBoV1-caused lower RTI (5,112).…”

Section: Diseases In Human Bocavirus Acute Infectionmentioning

confidence: 99%

Emerging Human Parvoviruses: The Rocky Road to Fame

Söderlund‐Venermo

2019

Annu. Rev. Virol.

Self Cite

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Parvoviruses are structurally simple viruses with linear single-stranded DNA genomes and nonenveloped icosahedral capsids. They infect a wide range of animals from insects to humans. Parvovirus B19 is a long-known human pathogen, whereas adeno-associated viruses are nonpathogenic. Since 2005, many parvoviruses have been discovered in human-derived samples: bocaviruses 1–4, parvovirus 4, bufavirus, tusavirus, and cutavirus. Some human parvoviruses have already been shown to cause disease during acute infection, some are associated with chronic diseases, and others still remain to be proven clinically relevant—or harmless commensals, a distinction not as apparent as it might seem. One initially human-labeled parvovirus might not even be a human virus, whereas another was originally overlooked due to inadequate diagnostics. The intention of this review is to follow the rocky road of emerging human parvoviruses from discovery of a DNA sequence to current and future clinical status, highlighting the perils along the way.

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“…HBoV1 infection causes acute respiratory tract infection (ARTI) in young children (Christensen et al., 2019; Qiu, Söderlund‐Venermo, & Young, 2017), with symptoms manifested as mild (similar to the common cold) or as severe pneumonia and bronchiolitis (Allander et al., 2007; Arnold, Singh, Spector, & Sawyer, 2006; Blessing, Neske, Herre, Kreth, & Weissbrich, 2009; Calvo et al., 2008; Choi et al., 2006; Del Rosal et al., 2015; do Amaral de, Amantea, Pilger, & Cantarelli, 2013; Don et al., 2011; Don et al., 2010; Fry et al., 2007; Kesebir et al., 2006; Longtin et al., 2008; Lu et al., 2006; Manning et al., 2006; Moriyama et al., 2010; Nascimento‐Carvalho et al., 2012; Neske et al., 2007; Pozo et al., 2007; Rezes et al., 2009; Ruohola et al., 2009; Schildgen, 2010; Schildgen et al., 2008; Schlaberg et al., 2017; Terrosi, Fabbiani, Cellesi, & Cusi, 2007; Ursic et al., 2012; Ursic et al., 2011; Wang et al., 2010; Xu et al., 2017). Sometimes, HBoV1 infection can be life threatening (Edner et al., 2011; Jula et al., 2013; Korner et al., 2011; Tabatabai et al., 2019; Ursic et al., 2011; Ursic, Krivec, Kalan, & Petrovec, 2015). It has been reported that mono‐detection of HBoV1 infection is significantly associated with community‐acquired pneumonia (Schlaberg et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

Human Bocavirus 1 Infection of Well‐Differentiated Human Airway Epithelium

2020

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Human bocavirus 1 (HBoV1) is a small DNA virus that belongs to the Bocaparvovirus genus of the Parvoviridae family. HBoV1 is a common respiratory pathogen that causes mild to life‐threatening acute respiratory tract infections in children and immunocompromised individuals, infecting both the upper and lower respiratory tracts. HBoV1 infection causes death of airway epithelial cells, resulting in airway injury and inflammation. In vitro, HBoV1 only infects well‐differentiated (polarized) human airway epithelium cultured at an air‐liquid interface (HAE‐ALI), but not any dividing human cells. A full‐length HBoV1 genome of 5543 nucleotides has been cloned from DNA extracted from a human nasopharyngeal swab into a plasmid called HBoV1 infectious clone pIHBoV1. Transfection of pIHBoV1 replicates efficiently in human embryonic kidney 293 (HEK293) cells and produces virions that are highly infectious. This article describes protocols for production of HBoV1 in HEK293 cells, generation of HAE‐ALI cultures, and infection with HBoV1 in HAE‐ALI. © 2020 Wiley Periodicals LLC. Basic Protocol 1: Human bocavirus 1 production in HEK293 cells Support Protocol 1: HEK293 cell culture and transfection Support Protocol 2: Quantification of human bocavirus 1 using real‐time quantitative PCR Basic Protocol 2: Differentiation of human airway cells at an air‐liquid interface Support Protocol 3: Expansion of human airway epithelial cell line CuFi‐8 Support Protocol 4: Expansion of human airway basal cells Support Protocol 5: Coating of plastic dishes and permeable membranes of inserts Support Protocol 6: Transepithelial electrical resistance measurement Basic Protocol 3: Human bocavirus 1 infection in human airway epithelium cultured at an air‐liquid interface Support Protocol 7: Isolation of infected human airway epithelium cells from inserts Basic Protocol 4: Transduction of airway basal cells with lentiviral vector

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Severe Human Bocavirus 1 Respiratory Tract Infection in an Immunodeficient Child With Fatal Outcome

Cited by 7 publications

References 30 publications

Human Bocavirus in Childhood: A True Respiratory Pathogen or a “Passenger” Virus? A Comprehensive Review

Human Bocavirus in Childhood: A True Respiratory Pathogen or a “Passenger” Virus? A Comprehensive Review

Emerging Human Parvoviruses: The Rocky Road to Fame

Human Bocavirus 1 Infection of Well‐Differentiated Human Airway Epithelium

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