Fatal cerebellar hemorrhage as an initial presentation of medulloblastoma in a child

Menekşe, Güner; Gezercan, Yurdal; Demırtürk, Pelin; Uysal, İsmail Önder; Ökten, Ali İhsan

doi:10.4103/1817-1745.165727

Cited by 9 publications

(6 citation statements)

References 7 publications

(11 reference statements)

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“…It always occurs in children and severely affects the physical and mental health of children (Ramaswamy et al, 2016). The increase of intracranial pressure triggered by blockage of the fourth ventricle is the main symptom of medulloblastoma, which usually appears for 1 to 5 months before diagnosis (Menekse et al, 2015). Additionally, truncal ataxia, diplopia, papillae edema, cranial nerve palsy, vertigo and nystagmus are also common symptoms of medulloblastoma (Polkinghorn and Tarbell, 2007;Brasme et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Yang

2020

Phytotherapy Research

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Icariin (ICA) is obtained from Epimedium brevicornu maxim and exploited to remedy miscellaneous cancers. But the role of ICA in medulloblastoma remains hazy. The research delved into the antitumor activity of ICA in medulloblastoma DAOY cells. ICA with diverse concentrations was utilized to stimulate DAOY cells, and the biological functions of ICA in medulloblastoma DAOY cells were examined. Then, the relative SPARC expression was determined in ICA‐managed DAOY cells, and the pc‐SPARC vector was transfected into DAOY cells to further probe the influence of SPARC and JAK1/STAT3 and PI3K/AKT pathways in ICA‐managed DAOY cells. A xenograft model was established to investigate the function of ICA in vivo. ICA restrained cell viability, expedited apoptosis, prohibited cell migration and invasion, and meanwhile affected the associative factors expression in DAOY cells. Additionally, SPARC expression was declined in ICA‐stimulated DAOY cells. Overexpressed SPARC reversed the functions of ICA in above‐involved cell behaviors of DAYO cells and the correlative protein levels. Besides, ICA notably frustrated JAK1/STAT3 and PI3K/AKT activations in DAOY cells. Beyond that, ICA prohibited tumor formation in vivo. The results concluded that ICA exhibited the antitumor activity in DAOY cells via decreasing SPARC and inactivating JAK1/STAT3 and PI3K/AKT pathways.

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Section: Introductionmentioning

confidence: 99%

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Yang

2020

Phytotherapy Research

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“…It is worth noting that 2 patients were newly diagnosed with CRC during hospitalization for ICH, suggesting that ICH might be the first manifestation of CRC. Cancers with ICH as the initial symptom include choriocarcinoma, leukocythemia, and medulloblastoma[ 15 - 17 ]. How to quickly identify insidious cancer in patients with ICH is still a challenge.…”

Section: Discussionmentioning

confidence: 99%

Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis

Deng¹,

Li²,

Chen³

et al. 2021

WJGO

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BACKGROUND The diagnosis of both cancer and intracerebral hemorrhage (ICH) in the same patient is not uncommon, but the clinical features and pathogenesis of patients with colorectal cancer (CRC) and ICH are still not well known. AIM To investigate the clinical features and underlying pathogenesis of ICH in patients with CRC. METHODS A retrospective review of CRC patients complicated with ICH from three centers between January 2014 and December 2020 was performed. Clinical data such as laboratory examinations, imaging features, prognosis, and underlying pathogenesis were analyzed. RESULTS Of 16673 identified CRC patients, 20 (0.12%) suffered from ICH. There were 13 males and 7 females, with an average age (mean ± SD) of 68.45 ± 10.66 years. Fourteen patients (70%) had distant metastases and most patients (85%) showed an elevation of one or more cancer biomarkers. The hemorrhagic lesions in 13 patients (65%) were in the intracerebral lobe. Four patients were completely dependent and 4 died within 30 days after hemorrhage. Intratumoral hemorrhage (50%) and coagulopathy (50%) accounted for the majority of hemorrhages. CONCLUSION Patients with ICH and CRC often have clinical features with lobar hemorrhage, distant metastases and poor prognosis. Intratumoral hemorrhage and coagulopathy are the main causes of ICH in patients with CRC.

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“…Medulloblastoma can present heterogeneous features on MRI with variable enhancement patterns, cystic areas, hemorrhage and calcification [ 21 ]. Although intratumoral bleeding can be found in brain tumors, only few cases of medulloblastoma with spontaneous hemorrhages have been reported in the literature [ 5 , 22 ]. Park et al showed that the incidence of spontaneous hemorrhage was 5.6 % in patients with primary or recurrent medulloblastoma [ 23 ].…”

Section: Case Presentationmentioning

confidence: 99%

“…However, the biological effect of Wnt/β-catenin signaling activation and the link with a better prognosis has not been clarified yet. Few cases of medulloblastoma presenting with spontaneous hemorrhage are reported in the literature [ 5 ]. Although some studies speculate on the etiology of the anomalous increased vascularization in medulloblastoma [ 6 ], a clear pathogenetic role has not been identified.…”

Section: Introductionmentioning

confidence: 99%

Anomalous vascularization in a Wnt medulloblastoma: a case report

et al. 2016

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BackgroundMedulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pathogenesis of this anomalous increased vascularization in medulloblastoma, the specific mechanism is still far from clearly understood. A correlation between molecular medulloblastoma subgroups and hemorrhagic features has not been reported, although recent preliminary studies described that WNT-subtype tumors display increased vascularization and hemorrhaging.Case presentationHerein, we describe a child with a Wnt-medulloblastoma presenting as cerebellar-vermian hemorrhagic lesion. Brain magnetic resonance imaging (MRI) showed the presence of a midline posterior fossa mass with a cystic hemorrhagic component. The differential diagnosis based on imaging included cavernous hemangioma, arteriovenous malformation and traumatic lesion. At surgery, the tumor appeared richly vascularized as documented by the preoperative angiography.ConclusionsThe case we present showed that Wnt medulloblastoma may be associated with anomalous vascularization. Further studies are needed to elucidate if there is a link between the hypervascularization and the Wnt/β-catenin signaling activation and if this abnormal vasculature might influence drug penetration contributing to good prognosis of this medulloblastoma subgroup.

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Fatal cerebellar hemorrhage as an initial presentation of medulloblastoma in a child

Cited by 9 publications

References 7 publications

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Retracted: Icariin inhibits proliferation, migration, and invasion of medulloblastoma DAOY cells by regulation of SPARC

Clinical features of intracerebral hemorrhage in patients with colorectal cancer and its underlying pathogenesis

Anomalous vascularization in a Wnt medulloblastoma: a case report

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