Fatal Case of Community-Acquired Pneumonia Caused by Legionella longbeachae in a Patient with Systemic Lupus Erythematosus

García, Celia; Ugalde, Estibaliz; Campo, Ana Belén; Miñambres, Eduardo; Kovács, N.

doi:10.1007/s10096-003-1071-7

Cited by 15 publications

(15 citation statements)

References 12 publications

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“…The global increase in infection rates is associated with soils and potting mixes This study did not identify an environmental source of infection ( 10 ). In 2004, a 25-year-old woman in Spain who had systemic lupus erythematosus died of community-acquired L. longbeachae –derived pneumonia ( 14 ). …”

Section: Disease Prevalencementioning

confidence: 99%

Legionella longbeachaeand Legionellosis

Whiley¹,

Bentham²

2011

Emerg. Infect. Dis.

131

134

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Reported cases of legionellosis attributable to Legionella longbeachae infection have increased worldwide. In Australia and New Zealand, L. longbeachae has been a known cause of legionellosis since the late 1980s. All cases for which a source was confirmed were associated with potting mixes and composts. Unlike the situation with other Legionella spp., L. longbeachae–contaminated water systems in the built environment that cause disease have not been reported. Spatially and temporally linked outbreaks of legionellosis associated with this organism also have not been reported. Sporadic cases of disease seem to be limited to persons who have had direct contact with potting soil or compost. Long-distance travel of the organism resulting in infection has not been reported. These factors indicate emergence of an agent of legionellosis that differs in etiology from other species and possibly in route of disease transmission.

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Section: Disease Prevalencementioning

confidence: 99%

Legionella longbeachaeand Legionellosis

Whiley¹,

Bentham²

2011

Emerg. Infect. Dis.

131

134

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“…However, although less common, the isolation of L. pneumophila from potting soil in Europe has also been reported (Casati et al, 2009; Velonakis et al, 2009). Human infection due to L. longbeachae is particularly common in Australia but cases have been documented also in other countries like the USA, Japan, Spain, England, or Germany (MMWR, 2000; Garcia et al, 2004; Kubota et al, 2007; Kumpers et al, 2008; Pravinkumar et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

Gómez-Valero¹,

Rusniok²,

Cazalet³

et al. 2011

Front. Microbio.

136

120

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Although best known for its ability to cause severe pneumonia in people whose immune defenses are weakened, Legionella pneumophila and Legionella longbeachae are two species of a large genus of bacteria that are ubiquitous in nature, where they parasitize protozoa. Adaptation to the host environment and exploitation of host cell functions are critical for the success of these intracellular pathogens. The establishment and publication of the complete genome sequences of L. pneumophila and L. longbeachae isolates paved the way for major breakthroughs in understanding the biology of these organisms. In this review we present the knowledge gained from the analyses and comparison of the complete genome sequences of different L. pneumophila and L. longbeachae strains. Emphasis is given on putative virulence and Legionella life cycle related functions, such as the identification of an extended array of eukaryotic like proteins, many of which have been shown to modulate host cell functions to the pathogen’s advantage. Surprisingly, many of the eukaryotic domain proteins identified in L. pneumophila as well as many substrates of the Dot/Icm type IV secretion system essential for intracellular replication are different between these two species, although they cause the same disease. Finally, evolutionary aspects regarding the eukaryotic like proteins in Legionella are discussed.

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“…This contrasts with the situation in Europe and the USA, where disease caused by L. longbeachae occurs predominantly or exclusively in immunosuppressed patients [14][15][16][17]. Case-series from Australia [18,19] suggest that immunosuppression is less apparent in cases seen there, but none have directly compared with cases of Legionnaires' disease caused by L. longbeachae disease caused by L. pneumophila.…”

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confidence: 99%

Legionnaires’ disease caused by Legionella longbeachae and Legionella pneumophila: comparison of clinical features, host-related risk factors, and outcomes

Amodeo

Murdoch

Pithie

2010

Clinical Microbiology and Infection

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Legionnaires' disease remains an important cause of mortality and morbidity worldwide. Disease caused by Legionella pneumophila has been extensively studied, and its clinical characteristics have been well described. There is, however, little information on disease caused by Legionella longbeachae, despite its importance in some countries. We undertook a retrospective review of culture-positive cases of Legionnaires' disease in the Canterbury region of New Zealand over 10 years, in order to compare the clinical features and outcomes of Legionnaires' disease caused by these two species.

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Fatal Case of Community-Acquired Pneumonia Caused by Legionella longbeachae in a Patient with Systemic Lupus Erythematosus

Cited by 15 publications

References 12 publications

Legionella longbeachaeand Legionellosis

Legionella longbeachaeand Legionellosis

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

Legionnaires’ disease caused by Legionella longbeachae and Legionella pneumophila: comparison of clinical features, host-related risk factors, and outcomes

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