Fatal carbon monoxide poisoning: A lesson from a retrospective study at All India Institute of Medical Sciences, New Delhi

Sikary, Asit Kumar; Dixit, Sumit; Murty, O.P.

doi:10.4103/jfmpc.jfmpc_408_16

Cited by 11 publications

(3 citation statements)

References 17 publications

(27 reference statements)

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“…Similarly, Huang et al (2017) reported high incidence of acute carbon monoxide (CO) poisoning among middle age patients. The reported predominance of males over females in the current study coincided with the findings observed by others studies (Shokrzadeh et al, 2013;Aldossary et al, 2015;Sikary et al, 2017). Meanwhile, it was contrary to the results of a study conducted in Morocco by Rebgui et al (2013) who recorded higher incidence of CO poisoning in females.…”

Section: Discussionsupporting

confidence: 82%

Assessment of Some Scoring Systems in Prediction of Mortality in Acute Carbon Monoxide Poisoned Patients

El-Gharbawy

Khalifa

2019

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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Glasgow coma scale, Acute physiology and chronic health evaluation II, simplified acute physiology score II, rapid emergency medicine score, carbon monoxide poisoning, prediction of mortality. Carbon monoxide (CO) is known as a silent killer. In Egypt, it is one of the most common causes of death-related poisonings. This study aimed to evaluate some scoring systems; Glasgow coma scale (GCS), acute physiology and chronic health evaluation II (APACHE II), simplified acute physiology score II (SAPS II) and rapid emergency medicine score (REMS) for predicting in-hospital mortality of patients with acute CO poisoning. One hundred and eight acutely CO poisoned patients were included in the study. For each patient, socio-demographic and toxicological data were recorded. Clinical examination and calculation of the four scoring systems were performed. Patients were divided into two groups; survivors and non-survivors. Discrimination was evaluated using ROC curve and calculating the area under the curve (AUC). The current study revealed that median age of the studied patients was 25.5 years, 55.6% were males and 61.1% were from rural areas. All cases were intoxicated accidently. Among the studied 108 patients; 20 patients died in hospital and 88 patients survived. Both APACHE II and SAPS II had the best AUC, followed by REMS then GCS. The AUC of GCS was significantly lower than those of APACHE II, SAPS II and REMS scores; while differences between AUC of APACHE II, SAPS, and REMS were not statistically significant. It could be concluded that REMS is more useful in predicting in-hospital mortality in acute CO poisoning as it is a simple, easy and rapid scoring system rather than more complicated scoring systems such as APACHE II and SAPS II.

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Section: Discussionsupporting

confidence: 82%

Assessment of Some Scoring Systems in Prediction of Mortality in Acute Carbon Monoxide Poisoned Patients

El-Gharbawy

Khalifa

2019

Mansoura Journal of Forensic Medicine and Clinical Toxicology

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“…In rural and semi-urban India, there is frequent use of indoor coal-burning heaters and stoves during winter months. Practices of using wood and other indigenous forms of cooking equipment are also not uncommon giving rise to increased CO emissions (Sikary et al, 2017).…”

Section: Research Articlementioning

confidence: 99%

Oral Mucosal Lesions’ propensity as an Outcome Eventuated by Exhaled Carbon Monoxide (CO) Levels and Nicotine Dependency

Naik

Gaunkar

Kamat

et al. 2021

Asian Pac J Cancer Prev

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Objective: This study aims to assess the correlation of exhaled CO and nicotine dependence with the occurrence of oral mucosal lesions while also taking into consideration socio-demographic, clinical and anthropometrical characteristics of participants. Methods: An observational cross-sectional study was carried out among smokers who visited the tobacco cessation center at Tertiary Care Dental Hospital in Goa, India. An intra-oral soft tissue examination for detecting presence of oral mucosal lesions followed by a questionnaire-based interview for the measurement of exposure, sociodemographic factors, body mass index, cooking habits and nicotine dependence was conducted. The exhaled CO levels were measured with a CO breath analyzer. Statistical analysis was performed using IBM SPSS version 20.0 Descriptive statistics were calculated and multivariable analysis was done to assess the association of different variables with oral mucosal lesions and carbon monoxide levels. p-value ≤ 0.05 was considered as statistically significant. Results: Of the 173 subjects enrolled in the study, 69.36% were without any lesions while 30.63% were diagnosed with some lesion. In the regression analysis, the variables of physical activity (present vs absent OR: 5.808), exhaled CO levels (OR: 1.098) and nicotine dependence (mild vs moderate OR: 6.518) were significant risk factors influencing the presence of oral mucosal lesions. Usage of both cigarettes and bidis by smokers exhibited highest mean exhaled CO values of 19.67±1.506 ppm. Exhaled CO levels were significantly higher in smokers who were overweight (14.96±9.14 ppm), physically inactive (13.98±8.26 ppm), highly nicotine dependent (20.67±8.30) and used coal for cooking (12.55±8.17). Conclusion: A robust correlation between exhaled CO levels, nicotine dependence and incidence of oral mucosal lesions was established. The multifactorial tenacity of exhaled CO which is affected by smoked tobacco as well as variables such as physical activity, BMI, cooking habits and type of smoking habit should be noted.

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“…[3]. Due to its properties, it is often difficult to detect the presence of CO, describing it as a 'silent killer' [4]. The inhalation of CO can deprive the capacity of blood to carry oxygen and combines with hemoglobin to form carboxyhemoglobin [5].…”

Section: Introductionmentioning

confidence: 99%

An 8 MeV Electron Beam Modified In:ZnO Thin Films for CO Gas Sensing towards Low Concentration

et al. 2021

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In the present investigation, electron beam-influenced modifications on the CO gas sensing properties of indium doped ZnO (IZO) thin films were reported. Dose rates of 5, 10, and 15 kGy were irradiated to the IZO nano films while maintaining the In doping concentration to be 15 wt%. The wurtzite structure of IZO films is observed from XRD studies post electron beam irradiation, confirming structural stability, even in the intense radiation environment. The surface morphological studies by SEM confirms the granular structure with distinct and sharp grain boundaries for 5 kGy and 10 kGy irradiated films whereas the IZO film irradiated at 15 kGy shows the deterioration of defined grains. The presence of defects viz oxygen vacancies, interstitials are recorded from room temperature photoluminescence (RTPL) studies. The CO gas sensing estimations were executed at an optimized operating temperature of 300 °C for 1 ppm, 2 ppm, 3 ppm, 4 ppm, and 5 ppm. The 10 kGy treated IZO film displayed an enhanced sensor response of 2.61 towards low concentrations of 1 ppm and 4.35 towards 5 ppm. The enhancement in sensor response after irradiation is assigned to the growth in oxygen vacancies and well-defined grain boundaries since the former and latter act as vital adsorption locations for the CO gas.

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Fatal carbon monoxide poisoning: A lesson from a retrospective study at All India Institute of Medical Sciences, New Delhi

Cited by 11 publications

References 17 publications

Assessment of Some Scoring Systems in Prediction of Mortality in Acute Carbon Monoxide Poisoned Patients

Assessment of Some Scoring Systems in Prediction of Mortality in Acute Carbon Monoxide Poisoned Patients

Oral Mucosal Lesions’ propensity as an Outcome Eventuated by Exhaled Carbon Monoxide (CO) Levels and Nicotine Dependency

An 8 MeV Electron Beam Modified In:ZnO Thin Films for CO Gas Sensing towards Low Concentration

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