Fatal Avian Influenza A H5N1 in a Dog

Songserm, Thaweesak; Amonsin, Alongkorn; Jam-on, Rungroj; Sae-Heng, Namdee; Pariyothorn, Nuananong; Payungporn, Sunchai; Theamboonlers, Apiradee; Chutinimitkul, Salin; Thanawongnuwech, Roongroje; Poovorawan, Yong

doi:10.3201/eid1211.060542

Cited by 239 publications

(162 citation statements)

References 12 publications

(12 reference statements)

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“…HPAIV has also been detected in commercial frozen duck carcasses of retained slaughter batches (Harder et al, 2009), which has increased concern about the food safety of poultry products by its zoonotic implications. Similarly, the transmission of H5N1 HPAIV from infected carcasses to other animals in HPAIV-endemic areas has also been reported in different carnivores such as domestic cats (Songserm et al, 2006a) and dogs (Songserm et al, 2006b), tigers and leopards (Keawcharoen et al, 2004) and red foxes (Reperant et al, 2008). Nevertheless, kinetic and systematic studies on the persistence of AIV in different tissues from infected carcasses have not been conducted.…”

Section: Introductionmentioning

confidence: 99%

Persistence of highly pathogenic avian influenza virus (H7N1) in infected chickens: feather as a suitable sample for diagnosis

Busquets

Abad

Alba

et al. 2010

Journal of General Virology

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Section: Introductionmentioning

confidence: 99%

Persistence of highly pathogenic avian influenza virus (H7N1) in infected chickens: feather as a suitable sample for diagnosis

Busquets

Abad

Alba

et al. 2010

Journal of General Virology

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“…Dogs are susceptible to multiple IAV subtypes. H3N8, H3N2, H3N1, H5N1, H5N2 and H9N2 IAVs have been detected in dogs (Crawford et al, 2005;Songserm et al, 2006;Su et al, 2014a, b;X. Sun et al, 2013;Y.…”

Section: Introductionmentioning

confidence: 99%

Identification of the IFN-β response in H3N2 canine influenza virus infection

San

et al. 2016

Journal of General Virology

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Canine influenza viruses (CIVs) circulate continuously in the dog population, providing opportunities for exposure to humans and other species. Although the dog genome has been sequenced, innate immunity in dogs is not well characterized, which limits the understanding of H3N2 canine influenza virus pathogenesis. Equally, how this virus evades the canine host innate immune response to successfully establish infection remains unclear. To analyse the IFN-b response to CIV infection in Madin-Darby canine kidney cells, the canine IFN-b promoter sequence and its positive regulatory domain motifs were first cloned and identified using a luciferase reporter system. Next, we found that infection with the CIV strain GD/12 blocked the IFN-b response primarily by inhibiting the NF-k B and IFN regulatory factor 3 (IRF3) signalling pathways. Expression of GD/12 non-structural protein 1 alone was sufficient to inhibit Sendai virus-induced NF-k B and IRF3 activation by suppressing p65 and IRF3 phosphorylation, suggesting the important role of this protein in the CIV-mediated inhibition of the IFN-b response. These results suggest that inhibition of the IFN-b signalling pathway may have played a role in CIV establishment and spread in dog populations.

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“…1,25 A subsequent serosurvey 5 revealed that 25% of 629 asymptomatic dogs had been exposed to the virus in Thailand. The transmission of an entire avian FLUAV subtype H3N2 to dogs in South Korea was identified in 2007, 23 and additional studies 16,24 support the sustained transmission of this avianorigin H3N2 virus between South Korean dogs.…”

Section: Introductionmentioning

confidence: 99%

A Diagnostic Algorithm for Detection of Antibodies to Influenza A Viruses in Dogs in Italy (2006–2008)

Benedictis

Anderson²,

Pérez

et al. 2010

J VET Diagn Invest

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Abstract. Since 2004, there have been several reports of Influenza A virus (FLUAV) infection in dogs. Dogs have been infected with equine influenza H3N8, avian influenza H3N2 and H5N1, and the pandemic H1N1 virus. Because of recent avian and equine influenza outbreaks in Italy, the objectives of the present study were to estimate the level of exposure of Italian dogs to influenza A viruses and to assess a diagnostic algorithm for detection of FLUAV exposure in dogs. Sera collected from 6,858 dogs from 2006 to 2008 were screened in a competitive enzyme-linked immunosorbent assay (cELISA) for antibodies to the highly conserved influenza A nucleoprotein. Samples positive in the cELISA were confirmed by testing in hemagglutination inhibition (HI) and fluorescent antibody test (FAT). Two seropositive dogs had antibodies to H3 hemagglutinin proteins, consistent with exposure to recent canine and equine subtype H3N8 viruses. Using a Bayesian model, the sensitivity and specificity of the cELISA were estimated as 93.98% (probability intervals [PI]: 81.67-99.08%) and 98.71% (PI: 98.43-98.96%), respectively. After accounting for the imperfect sensitivity and specificity of the cELISA, the Bayesian posterior prevalence of FLUAV exposure among tested Italian dogs was 0.5% (PI: 0.1-1.4%). The study results indicate that screening with a cELISA for influenza A nucleoprotein antibody, followed by confirmatory testing with HI and/or FAT, is a highly sensitive and highly specific approach for diagnosing FLUAV exposure in dogs.

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Fatal Avian Influenza A H5N1 in a Dog

Cited by 239 publications

References 12 publications

Persistence of highly pathogenic avian influenza virus (H7N1) in infected chickens: feather as a suitable sample for diagnosis

Persistence of highly pathogenic avian influenza virus (H7N1) in infected chickens: feather as a suitable sample for diagnosis

Identification of the IFN-β response in H3N2 canine influenza virus infection

A Diagnostic Algorithm for Detection of Antibodies to Influenza A Viruses in Dogs in Italy (2006–2008)

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