Fatal Aspiration Pneumonia During Transition from Donepezil to Rivastigmine

Emergent Complications Following Donepezil Switchover to Galantamine in Three Cases of Dementia With Lewy Bodies

“…[12][13][14] In an open trial involving PD and DLB, abrupt donepezil discontinuation led to delusions, irritability and hallucinations. 11,15 In our series, introduction of the second ChEI did not lead to immediate sequelae. 14 Our patients were closely followed in the first 2-week period following the switch, which enabled thorough ongoing assessments.…”

“…11 None of our patients experienced symptoms suggestive of cholinergic excess. It is possible that overlap of two ChEIs may have led to additive toxicity, so-called "cholinergic toxicity."…”