Fat Within the Wall of the Urinary Bladder

Thickman, David

doi:10.1097/rct.0b013e31818d8de6

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…This is thought to be an incidental benign finding, representing a normal variant in body fat distribution, which is more common in men [27,28]. On pathology, adipose tissue within the lamina propria can be seen in up to 53% of cystectomy specimens, with detectable The mass is homogeneously enhancing on early (axial) and delayed (sagittal) post-gadolinium enhanced images (black arrow) in (B).…”

Section: Fat-containing Lesionsmentioning

confidence: 92%

Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging

et al. 2015

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Compared to the more common urothelial lesions, at cystoscopy, suburothelial and extrinsic diseases of the urinary bladder wall often have a non-specific appearance or may be occult. Cross-sectional imaging, in particular MRI, plays an integral role in diagnosis. Mesenchymal tumors have distinct imaging features on MRI. Leiomyomas are characteristically low signal intensity on T2-weighted (T2W) imaging and progressively enhance. Lipomas and lipomatous hypertrophy are diagnosed by the presence of macroscopic fat. Neurofibromas, hemangiomas, and paragangliomas are hyperintense on T2W sequences and hypervascular. Reactive lesions occur in the setting of chronic inflammation and include: nephrogenic adenoma, cystitis cystica, and cystitis glandularis. Imaging findings are commonly non-specific; however, a mass with internal cystic spaces in association with pelvic lipomatosis is suggestive of cystitis glandularis. Urachal anomalies may be complicated by infection or malignancy. Urachal mucinous adenocarcinoma has a poor prognosis and may present as a T2-hyperintense suburothelial/extrinsic mass centered in the bladder dome. Other diseases may extrinsically involve the urinary bladder by hematogenous and peritoneal spread, including infection, endometriosis, and malignancy. A familiarity with suburothelial and extrinsic pathologies of the urinary bladder is critical for the radiologist, who may be the first to suggest these diagnoses.

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Section: Fat-containing Lesionsmentioning

confidence: 92%

Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging

et al. 2015

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“…[1,26,27] Previously, computed tomography reported that 30 out of 200 people (15%) had fat in their bladder walls. [28] These previous studies indicated the potential for urinary BPA to accumulate in the bladder. Given that exposure to BPA is ubiquitous and BPA can bioaccumulate in the bladder, high-dose BPA toxicity studies are meaningful.…”

Section: Bpa Induced the Apoptosis Of Human Bladder Cells Through The...mentioning

confidence: 94%

Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation

Song,

Hwang,

Park

et al. 2024

J Biochem & Molecular Tox

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Bisphenol A (BPA), an exogenous endocrine‐disrupting chemical, is widely used to produce polycarbonate plastics. The widely used BPA has been detected in human urine samples, raising public anxiety about the detrimental effects of BPA on the bladder. In this study, we explored regulatory mechanisms for the adverse effects of BPA in human bladder BdFC and T24 cells. BPA induced extrinsic and intrinsic apoptosis and G2/M cell cycle arrest caused by the ATM‐CHK1/CHK2‐CDC25c‐CDC2 signaling, which ultimately inhibited the growth of human bladder cells. We also found that BPA decreased the binding activity of AP‐1 and NF‐κB transcription factors in human bladder cells, which inhibited migration and invasion through matrix metallopeptidase‐2 and ‐9 inactivation. Phosphorylation of MAPKs was implicated with BPA‐mediated detrimental effects in human bladder cells. Collectively, our results provide a novel explanation for the underlying molecular mechanisms that BPA induces cytotoxicity in human bladder cells.

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“…Deposition of nonencapsulated macroscopic fat within the suburothelial layers of the urinary bladder is a common and likely incidental finding (Figure 4), with male predominance. 24,25 At histopathology, mature adipose tissue is present in the bladder wall in up to 53% of cystectomy specimens, with detectable suburothelial macroscopic fat described in up to 15% of patients at CT or MRI. 25,26 Reproductive Organs…”

Section: Suburothelial Fat Depositionmentioning

confidence: 99%

Extrahepatic Fat-Containing Lesions of the Abdomen and Pelvis: An Organ-Based Approach to Differential Diagnoses

Chung

2020

Can Assoc Radiol J

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The presence of intralesional fat provides an invaluable tool for narrowing the differential diagnosis for both benign and malignant neoplasms of the abdomen and pelvis. The ability to characterize intralesional fat is further expanded by the ability of magnetic resonance imaging to detect small quantities (intravoxel) of fat. While the presence of intralesional fat can help to provide a relatively narrow set of diagnostic possibilities, depending on the type of fat (macroscopic vs intravoxel) that is present and the organ of origin, radiologists must be aware of uncommon mimickers of pathology, both benign and malignant.

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Fat Within the Wall of the Urinary Bladder

Abstract: Fat within the wall of the urinary bladder can be a normal histological finding that is detected at computed tomography typically in patients with nondistended urinary bladders on unenhanced studies.

Cited by 8 publications

References 6 publications

Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging

Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging

Bisphenol A regulates bladder cells responses via control of G2/M‐phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor‐associated MMP modulation

Extrahepatic Fat-Containing Lesions of the Abdomen and Pelvis: An Organ-Based Approach to Differential Diagnoses

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