Fat, Stem Cells, and Platelet-Rich Plasma

James, Isaac; Coleman, Sydney R.; Rubin, J. Peter

doi:10.1016/j.cps.2016.03.017

Cited by 49 publications

(28 citation statements)

References 130 publications

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“…In dermatology and plastic surgery, PRP has been widely applied for skin rejuvenation, scalp alopecia, associated with fat grafts, after laser peeling, and for prevention of hematoma in facelift procedures [52][53][54][55][56]. Derived growth factor platelets have been described for regenerative purposes [57] and other studies suggest paracrine effect, angiogenic action, and cell proliferation inducer [58,59]. Despite the widespread use of PRP as a regenerative agent, its efficacy has yet to be confirmed in different clinical protocols, mainly for effects, the durability of results, proper dosing, preparation techniques, and comparison of results [35].…”

Section: Discussionmentioning

confidence: 99%

“…At the moment, the biological mechanisms responsible for the rejuvenating and regenerative effect on human skin obtained with the fat graft and/or its components are not yet clearly understood, and there is no consensus on the histological and ultrastructural changes that occur in the skin and subcutaneous tissue, after ADSC and PRP therapies [ 39 – 43 ].…”

Section: Introductionmentioning

confidence: 99%

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Photoaging Skin Therapy with PRP and ADSC: A Comparative Study

Charles-de-Sá

Gontijo-de-Amorim

Sbarbati

et al. 2020

Stem Cells International

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Background. Stem cells from adipose tissue (ADSCs) and platelet-rich plasma (PRP) are innovative modalities that arise due to their regenerative potential. Objective. The aim of this study was to characterize possible histological changes induced by PRP and ADSC therapies in photoaged skin. Methods. A prospective randomized study involving 20 healthy individuals, showing skin aging. They underwent two therapeutic protocols (protocol 1: PRP; protocol 2: ADSCs). Biopsies were obtained before and after treatment (4 months). Results. PRP protocol showed unwanted changes in the reticular dermis, mainly due to the deposition of a horizontal layer of collagen (fibrosis) and elastic fibers tightly linked. Structural analyses revealed infiltration of mononuclear cells and depot of fibrotic material in the reticular dermis. The ADSC protocol leads to neoelastogenesis with increase of tropoelastin and fibrillin. There was an improvement of solar elastosis inducing an increment of macrophage polarization and matrix proteinases. These last effects are probably related to the increase of elastinolysis and the remodeling of the dermis. Conclusions. The PRP promoted an inflammatory process with an increase of reticular dermis thickness with a fibrotic aspect. On the other hand, ADSC therapy is a promising modality with an important antiaging effect on photoaged human skin.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Photoaging Skin Therapy with PRP and ADSC: A Comparative Study

Charles-de-Sá

Gontijo-de-Amorim

Sbarbati

et al. 2020

Stem Cells International

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“…In addition, the effectiveness of platelet-rich plasma and basic fibroblast factor has been reported in the recent years. [ 2 , 24 ] These novel treatments may become the first choice for treating depression deformities in the future but can be performed in only a limited number of institutions because of financial, institutional, and technical problems. In contrast, augmentation with a pedicled BFP can be conducted in any institution.…”

Section: Discussionmentioning

confidence: 99%

Pedicled buccal fat pad for the augmentation of facial depression deformity

Komatsu

Ikemura

Kimata³

2017

Medicine

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Rationale:Tissue augmentation of facial depression deformities can be achieved by volume replacement with autologous fat injection, dermal filler injection, etc. Here, we report a case of tissue augmentation of a facial depression deformity using a pedicled buccal fat pad (BFP).Patient concerns:A 64-year-old woman was referred with a chief complaint of facial depression deformity.Diagnoses:Her molars had been removed at another hospital 12 years prior to this referral, and the patient suffered from a left cheek depression deformity as a sequela of a postextraction infection.Interventions:An incision was made in the left gingivobuccal sulcus under local anesthesia, and BFP was carefully excised from its normal location. The subcutaneous scar tissue was dissected, and a pocket was created via the same mucosal incision. BFP was then pushed into the pocket.Outcomes:The depression deformity immediately disappeared postoperatively. The transplanted BFP remained unabsorbed and soft 43 months postoperatively. The patient did not have any complications.Lessons:This novel procedure has 2 advantages. First, the pedicled BFP is a vascularized tissue and is not absorbed postoperatively; control of contour is easy, and only 1 treatment session is required. Complications associated with fat necrosis can be avoided. Second, only a single intraoral incision is required; the risk of donor-site morbidity is very low, and scar formation does not occur on exposed skin. Third, this procedure can be performed without special instruments and equipment. The main disadvantages are limited rotation arc and volume of pedicled BFP. Despite its limited application, this procedure is simple and useful, with low invasiveness.

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“…In addition to its known filling effect, AFG is considered a potential mechanism for treating scars owing to the presence of adipose tissue derived stem cells (ADSCs) which have a high regenerative ability and can repair injured tissues. 3,4…”

Section: Introductionmentioning

confidence: 99%