Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Wang, Yan; Cheng, Zhiqiang; Xu, Jing; Lai, Meina; Li, Liming; Zuo, Min; Lin, Dong

doi:10.1080/21655979.2021.1924544

Cited by 23 publications

(14 citation statements)

References 41 publications

(48 reference statements)

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“…Compared with a 2D cell culture system, such as Wang’s and Yao’s researches used [ 35 , 36 ], a 3D organoid culture system mimics the in situ tissue more closely. Thus, tumor-derived organoids from AME of the breast are a promising model for the clinical assessment of treatment regimens, evaluation of new drugs, and research on drug targets.…”

Section: Discussionmentioning

confidence: 99%

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast

Luo

She

et al. 2021

Bioengineered

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Adenomyoepithelioma (AME) of the breast is a rare tumor that is composed of proliferating epithelial and myoepithelial cells. The pathogenesis of AME remains unclear, and no breast cancer cells have been identified in such tumor tissues. In this study, we established patient-derived breast cancer organoids from the surgical tumor samples of an elderly Chinese woman with an AME of the breast. Our findings confirmed the successful establishment of organoids from an AME of the breast of this patient. A short tandem repeat analysis revealed that the DNA signature of the AME of the breast organoids matched the DNA signature of the original tumor specimen. Moreover, diameter assay confirmed that the organoids from the breast AME showed sensitivity to paclitaxel and doxorubicin treatments, which was similar to, but lesser than that of primary culture cells. In conclusion, we established an efficient 3-dimensional breast cancer organoid culture platform from an AME of the breast. This platform can be effectively used for exploring clinicopathological and genomic characteristics of AME of the breast to identify possible treatments and increase awareness about this disease entity.

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Section: Discussionmentioning

confidence: 99%

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast

Luo

She

et al. 2021

Bioengineered

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“…Studies showed that FTO reduced the level of m6A on ASB2 and RARA mRNA transcripts, regulated the expression of targets, including ASB2 and RARA, inhibited the differentiation of AML cells induced by all-trans-retinoic acid (ATRA), and promoted the progression of AML [18]. FTO promoted tumor progression in liver cancer [76][77][78], lung cancer [79][80][81][82][83], breast cancer [84][85][86], cervical cancer [87][88][89],…”

Section: Erasersmentioning

confidence: 99%

Role of m6A writers, erasers and readers in cancer

Fang

Mei

et al. 2022

Exp Hematol Oncol

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The N(6)-methyladenosine (m6A) modification is the most pervasive modification of human RNAs. In recent years, an increasing number of studies have suggested that m6A likely plays important roles in cancers. Many studies have demonstrated that m6A is involved in the biological functions of cancer cells, such as proliferation, invasion, metastasis, and drug resistance. In addition, m6A is closely related to the prognosis of cancer patients. In this review, we highlight recent advances in understanding the function of m6A in various cancers. We emphasize the importance of m6A to cancer progression and look forward to describe future research directions.

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“…However, few studies have investigated the molecular mechanisms governing FTO expression in cancer. In breast cancer, STAT3 binds to the FTO promoter to induce its transcription 80 . FTO is also regulated at the transcriptional level in lung cancer 77] .…”

Section: ‘Context-dependent’ Function Of Fto In Cancermentioning

confidence: 99%

The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells

2022

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The last decade has seen mRNA modification emerge as a new layer of gene expression regulation. The Fat mass and obesity-associated protein (FTO) was the first identified eraser of N6-methyladenosine (m6A) adducts, the most widespread modification in eukaryotic messenger RNA. This discovery, of a reversible and dynamic RNA modification, aided by recent technological advances in RNA mass spectrometry and sequencing has led to the birth of the field of epitranscriptomics. FTO crystallized much of the attention of epitranscriptomics researchers and resulted in the publication of numerous, yet contradictory, studies describing the regulatory role of FTO in gene expression and central biological processes. These incongruities may be explained by a wide spectrum of FTO substrates and RNA sequence preferences: FTO binds multiple RNA species (mRNA, snRNA and tRNA) and can demethylate internal m6A in mRNA and snRNA, N6,2′-O-dimethyladenosine (m6Am) adjacent to the mRNA cap, and N1-methyladenosine (m1A) in tRNA. Here, we review current knowledge related to FTO function in healthy and cancer cells. In particular, we emphasize the divergent role(s) attributed to FTO in different tissues and subcellular and molecular contexts.

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Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin

Abstract: 2021) Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin,

Cited by 23 publications

References 41 publications

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast

Establishment and characterization of organoids from a patient with adenomyoepithelioma of the breast

Role of m6A writers, erasers and readers in cancer

The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells

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