Fat Injection for Cases of Severe Burn Outcomes: A New
Perspective of Scar Remodeling and Reduction

Klinger, Marco; Marazzi, Mario; Vigo, D.; Torre, Maria Luisa

doi:10.1007/s00266-020-01813-z

Cited by 29 publications

(30 citation statements)

References 28 publications

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“…This effect is probably due to the presence of mesenchymal stem cells (ADSC) in the stromovascular component of adipose tissue, 12,13 with consequent new deposition of collagen, neoangiogenesis, and dermal hyperplasia. Based on this evidence our group adopted autologous fat graft in various clinical conditions characterized by atrophy or fibrosis of the skin, such as burns, 14 perioral sclerodermia, 15 irradiated tissues, 16 and chronic post‐traumatic ulcers 17 …”

Section: Discussionmentioning

confidence: 99%

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Autologous fat grafting efficacy in treating PostMastectomy pain syndrome: A prospective multicenter trial of two Senonetwork Italia breast centers

et al. 2020

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Postmastectomy pain syndrome (PMPS) represents a common complication following breast surgery defined as a chronic neuropathic pain located in the front of the chest, in the axilla and in the upper arm that for more than 3 months after surgery. Several medications prove to be ineffective while autologous fat grafting revealed to be an innovative solution in the treatment of neuropathic pain syndromes based on retrospective studies. For this reason, we performed a prospective multicenter trial to reduce the memory bias and further increase the evidence of the results. From February 2018 to March 2019, 37 female patients aged between 18 and 80 years, underwent mastectomy or quadrantectomy with pathologic scarring and chronic persistent neuropathic pain, compatible with PMPS, are been included in the study and treated with autologous fat grafting. During the enrollment phase, patients were asked to estimate pain using the Visual Analogue Scale (VAS)

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Section: Discussionmentioning

confidence: 99%

“…Our group extensively adopted such a procedure to treat scar tissue‐related pathologies, degenerative diseases, and volume deformities 9‐17 …”

Section: Introductionmentioning

confidence: 99%

Autologous fat grafting efficacy in treating PostMastectomy pain syndrome: A prospective multicenter trial of two Senonetwork Italia breast centers

et al. 2020

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“…This is made possible by the presence of ASCs in the fat tissue. From a histological point of view, autologous fat grafts show the ability to regenerate the dermis and subcutaneous tissue and improve the dermal and dermohypodermic quality in scar areas, with increasing amount of fat layer - largely destroyed in cases of thermal insults and poorly regenerated during tissue repair after any type of trauma - new collagen deposition, and local neoangiogenesis [83] , [84] , [85] . Mojallal et al.…”

Section: Applicationsmentioning

confidence: 99%

Procedure, applications, and outcomes of autologous fat grafting

Simonacci

Bertozzi

Grieco

et al. 2017

Annals of Medicine &Amp; Surgery

243

227

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ObjectiveTo systematically review the procedure, applications, and outcomes of autologous fat grafting, a promising technique with various clinical applications.Patients and methodsLiterature review of publications concerning autologous fat grafting.ResultsSince its introduction, lipofilling has become increasingly popular; however, its results are variable and unpredictable. Several modifications have been made to the procedures of fat harvesting, processing, and injecting. Surgical excision and low negative-pressure aspiration with large-bore cannulas minimize adipocyte damage during fat harvesting. The “wet” method of fat harvesting involves fluid injection at the donor site and facilitates lipoaspiration while minimizing pain and ecchymosis. For fat processing, centrifugation at a low speed is preferable to high-speed centrifugation, gravity separation or filtration. Fat injection at the recipient site should be performed using small-gauge cannulas in a fanning out pattern over multiple sessions, rather than a single session. Fat grafts exhibit not only dermal filler properties but also regenerative potential owing to the presence of stem cells in fat tissue. Thus, the clinical applications of autologous fat grafting include correction of secondary contour defects after breast reconstruction, release of painful scar contractures, and treatment of burn scars and radiodermatitis. Lipofilling is also used in aesthetic surgery, such as facial and hand rejuvenation, augmentation rhinoplasty, and breast and gluteal augmentation. The complications of lipofilling are minimal and include bruising, swelling, pain, infection, necrosis, and calcification.ConclusionsLipofilling is a low-risk procedure that can be used to correct soft-tissue defects in the face, trunk, and extremities, with minimal discomfort for patients.

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“…In a different study, Klinger et al reported improvement in skin elasticity, texture and thickness in three patients with hemifacial hypertrophic scars and keloids secondary to severe burns. 33 Histological examinations by punch biopsies before and after fat grafting demonstrated new collagen deposition, local hypervascularity and dermal hyperplasia. Magnetic resonance scans were also performed showing similar and relatively symmetrical soft tissue signal enhancement on both the affected and unaffected sides.…”

Section: Resultsmentioning

confidence: 95%

Autologous fat grafting in keloids and hypertrophic scars: a review

Lee

Hunter-Smith

Rozen

2017

Scars, Burns & Healing

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Keloid and hypertrophic scars are unique human dermal fibroproliferative disorders of the injured skin and are associated with pain, itch and can cause functional limitations. A number of genetic, systemic and local factors have been identified in the formation of keloids and hypertrophic scars. Studies have shown that adipose-derived stem cells have angiogenic and antiapoptotic properties which has effects on wound healing, soft-tissue restoration and scar remodelling, and thus may have a role in managing keloid scaring. However, this role is not well described in the literature. A systemic review of available literature was thus undertaken, regarding the use of fat grafting in treatment of keloids and hypertrophic scarring. In total, 858 articles were identified, with ten studies ultimately fulfilling inclusion criteria. There were no studies specifically isolating the keloids and hypertrophic group of patients, and thus quantitative data were completely lacking from the literature. There were, however, individual cases described, and qualitatively encouraging clinical results were reported for the use of fat grafting on keloids and hypertrophic scars. Combined with the current theoretical and immunohistochemical understanding through other laboratory and animal studies, fat grafting may play a role in the treatment of keloids and hypertrophic scaring; however, specific evidence is currently lacking. The role for further research is clear.

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Fat Injection for Cases of Severe Burn Outcomes: A New Perspective of Scar Remodeling and Reduction

Cited by 29 publications

References 28 publications

Autologous fat grafting efficacy in treating PostMastectomy pain syndrome: A prospective multicenter trial of two Senonetwork Italia breast centers

Autologous fat grafting efficacy in treating PostMastectomy pain syndrome: A prospective multicenter trial of two Senonetwork Italia breast centers

Procedure, applications, and outcomes of autologous fat grafting

Autologous fat grafting in keloids and hypertrophic scars: a review

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