Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism

Maruyama, Shoichi; Shibata, Rei; Kikuchi, Ryosuke; Izumiya, Yasuhiro; Rokutanda, Taku; Araki, Satoshi; Kataoka, Yasufumi; Ohashi, Koji; Daida, Hiroyuki; Kihara, Shinji; Ogawa, Hisao; Murohara, Toyoaki; Ouchi, Noriyuki

doi:10.1074/jbc.m111.261818

Cited by 150 publications

(109 citation statements)

References 35 publications

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“…The NO derived from the eNOS pathway acts as a mediator of the effects of estrogen in bone, and its relative deficiency may be involved in postmenopausal women [29]. Omentin-1 can stimulate the Akt-eNOS signaling pathway [30].…”

Section: Discussionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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The bone and fat interface is implicated in the pathogenesis of postmenopausal osteoporosis. The association between circulating omentin-1 levels and bone mineral density (BMD) in postmenopausal women has never been assessed. A total of 382 healthy postmenopausal women were randomly selected. Omentin-1, visfatin, adiponectin, the receptor activator of nuclear factor-κB ligand (RANKL), osteoprotegerin, high sensitivity C-reactive protein, degradation products of C-terminal telopeptides of type I collagen, and osteocalcin were measured by highly specific enzyme-linked immunosorbent assay methods. BMD was determined for the lumbar spine (L2-L4) and the proximal femur using dual-energy X-ray absorptiometry. In multivariable-adjusted linear regression, serum omentin-1 levels were inversely correlated with BMD at the lumbar spine (β =−0.11, p= 0.020). In multiple regression analyses, serum visfatin and adiponectin levels were not significantly correlated with BMD at different skeletal sites after controlling for age, body mass index, and bone-related markers. However, the highest quartile of adiponectin compared to the lowest quartile, after adjusting for potential confounders, revealed an inverse association with BMD in the lumbar spine (β=−0.19, p=0.010). In conclusion, circulating omentin-1 levels had an inverse correlation with BMD at the lumbar spine in Iranian postmenopausal women. To further understand the role of omentin-1 in bone and mineral metabolism, large-scale longitudinal studies focusing on BMD and osteoporotic fractures are warranted.

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Section: Discussionmentioning

confidence: 99%

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Tohidi

Akbarzadeh

Larijani

et al. 2012

Bone

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“…Maruyama i wsp. wykazali wpływ omentyny na funkcje komórek śródbłonka oraz proces rewaskularyzacji w odpowiedzi na niedokrwienie poprzez stymulację szlaku sygnałowego kinazy Akt-eNOS [12]. Działa-nie przeciwzapalne wiąże się także z supresyjnym oddziaływaniem omentyny na kinazę regulowaną zewnątrzkomórkowo (ERK) oraz czynnik jądrowy κB (nuclear factor κB -NF-κB).…”

Section: Omentynaunclassified

“…It prevents the activation of c-Jun N-terminal kinase (JNK), probably via the activation of signalling pathways engaging AMPK (5' adenosine monophosphate-activated protein kinase), endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) [11]. Maruyama et al have shown omentin to affect the functions of endothelial cells and the process of revasculatization in response to ischaemia through the stimulation of the kinase AkteNOS signalling pathway [12]. The anti-inflammatory activity is also linked to the suppressive effect of omentin on the extracellular signal-regulated kinase (ERK) and the nuclear factor-κB (NF-κB), thus inhibiting the TNF-α which induces intercellular adhesion molecules-1 (ICAM-1) and vascular cell adhesion molecules-1 (VCAM-1) [13].…”

Section: Omentynamentioning

confidence: 99%

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

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Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. stReszczenIe Łuszczyca jest przewlekłą chorobą skóry, w której ogólnoustrojowy stan zapalny wiąże się ze zwiększonym ryzykiem rozwoju powikłań metabolicznych i sercowo-naczyniowych. Szczególne znaczenie w podtrzymaniu stanu zapalnego w organizmie ma otyłość. Tkanka tłuszczo-wa jest aktywnym organem endokrynnym, który poprzez wydzielane adipokiny bierze udział w regulacji licznych szlaków metabolicznych ustroju. Otyłość zwiększa ryzyko rozwoju cukrzycy typu 2, miażdżycy, chorób sercowo-naczyniowych oraz nadciśnienia. W pracy przedstawiono charakterystykę stosunkowo nowo odkrytych i mało poznanych adipokin: omentyny i waspiny, którym przypisuje się korzystne działanie, chroniące przed rozwojem zaburzeń metabolicznych towarzyszących otyłości. Ponadto zwrócono uwagę na ich potencjalny udział w patogenezie łuszczycy oraz możliwość wykorzystania jako markerów nasilenia choroby oraz ryzyka rozwoju powikłań metabolicznych.

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“…Current available data suggested its range of effects on various cell types [3][4] . Serum omentin-1 concentrations were reported to correlate passively with BMI and waist circumference [5] .…”

Section: Introductionmentioning

confidence: 99%

Omentin-1 in serum and seminal plasma correlate with semen quality

et al. 2017

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Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types. Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia. Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS). Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men. Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.

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Fat-derived Factor Omentin Stimulates Endothelial Cell Function and Ischemia-induced Revascularization via Endothelial Nitric Oxide Synthase-dependent Mechanism

Cited by 150 publications

References 35 publications

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Omentin-1 in serum and seminal plasma correlate with semen quality

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