Fasudil Is a Superior Vasodilator for the Internal Thoracic Artery in Coronary Surgery

Abstract

Background. Internal thoracic artery (ITA) is a very useful conduit for coronary artery

Fasudil is an Effective Graft Vasodilator for Gastroepiploic Artery in Coronary Artery Bypass Grafting

“…This method allowed us to evaluate only the local effect of vasodilators on GEA, independent of other grafts and hemodynamic factors. With local application alone, fasudil demonstrates superior vasodilatory effect for internal thoracic artery, 22 radial artery, 16 and GEA, with no hemodynamic changes, no perioperative myocardial infarction, and no vasodilator-related complications. This agent may become the standard vasodilator for arterial graft pretreatment in CABG.…”

“…20 In patients with intractable coronary vasospasm after CABG not responding to maximum vasodilatory therapy, fasudil treatment markedly ameliorated the conditions. 21 To apply the potent vasodilatory effect of the Rho kinase inhibitor to CABG, we previously investigated the vasodilatory effect of fasudil on human internal thoracic artery 22 and radial artery grafts 16 and showed the superior vasodilating effect of fasudil over papaverine and VG for both grafts. In the present study, we found that fasudil increased GEA GFF more than threefold, also significantly and markedly more potent than papaverine and VG.…”

Management of Internal Mammary Artery Spasm

“…After relieving the spasm, it is important to maintain the vessel patency by administering dilators and avoiding constrictors. Here is a list of drugs that cause IMA dilation: sodium nitroprusside [21], organic nitrates [38], calcium channel blockers [4] [52], 17beta-estradiol (evidence only for females) [39], natriuretic peptides [40], low molecular weight heparin [41], alpha-adrenergic blockers (in benign prostate hyperplasia), resveratrol [42], iloprost [43], fasudil [44].…”

Advancing coronary artery bypass grafting: the fasudil-nitroglycerin cocktail as a potential antispastic solution

“…A more recent study compared the antispastic effect of the commonly used vasodilator, papaverine, with the Rho-kinase inhibitor, fasudil, on free flow following intraluminal injection in the isolated ITA ( 8 ). Fasudil exhibited a very potent vasodilatory effect compared with conventional papaverine.…”