FastSPECT II: a second-generation high-resolution dynamic SPECT imager

Furenlid, Lars R.; Wilson, Donald W.; Chen, Yi‐Chun; Kim, Hyunki; Pictraski, P.J.; Crawford, Michael J.; Barrett, Harrison H.

doi:10.1109/tns.2004.830975

Cited by 198 publications

(91 citation statements)

References 8 publications

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“…There are many methods to estimate this system matrix. A more accurate approach to construct such a system matrix is to measure the point spread function either by using real point source or through Monte-Carlo simulation [9,10]. This approach can generate a accurate matrix and it also contains all intrinsic characteristics of scanner, such as detector efficiency.…”

Section: Introductionmentioning

confidence: 99%

Fast iterative reconstruction for helical pinhole SPECT imaging

Huang

Hsu

2015

BME

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Abstract. Pinhole SPECT for small animal has become a routine procedure in many applications of molecular biology and pharmaceutical development. There is an increasing demand in the whole body imaging of lab animals. A simple and direct solution is to scan the object along a helical trajectory, similar to a helical CT scan. The corresponding acquisition time can be greatly reduced, while the over-lapping and gap between consecutive bed positions can be avoided. However, helical pinhole SPECT inevitably leads to the tremendous increase in computational complexity when the iterative reconstruction algorithms are applied. We suggest a novel voxel-driven (VD) system model which can be integrated with geometric symmetries from helical trajectory for fast iterative image reconstruction. Such a model construction can also achieve faster calculation and lower storage requirement of the system matrix. Due to the independence among various symmetries, it permits parallel coding to further boost computation efficiency of forward/backward projection. From phantom study, the results also indicate that the proposed VD model can adequately model the helical pinhole SPECT scanner with manageable storage size of system matrix and clinically acceptable computation loading of reconstruction.

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Section: Introductionmentioning

confidence: 99%

Fast iterative reconstruction for helical pinhole SPECT imaging

Huang

Hsu

2015

BME

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“…It was soon accepted that multi-pinhole collimators provide the best trade-off between spatial resolution and sensitivity [2]. Numerous multi-pinhole systems exist, from which the most important 5 have been developed by McElroy [3] (A-SPECT), Schramm [4] (HiSPECT), Furenlid [5,6] (FastSPECTII), Lackas [7] (T-SPECT), Beekman [8] (U-SPECT), Kim [9] (SemiSPECT) and Funk [10]. An excellent overview of multi-pinhole collimation for pre-clinical imaging can be found in [2].…”

Section: Introductionmentioning

confidence: 99%

Design and performance of a compact and stationary microSPECT system

et al. 2013

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Purpose: Over the past ten years, there has been an extensive growth in the development of microSPECT imagers. Most of the systems are based on the combination of conventional, relatively large gamma cameras with poor intrinsic spatial resolution and multi-pinhole collimators working in large magnification mode. Spatial resolutions range from 0.58 to 0.76 mm while peak sensitivities vary from 0.06% to 0.4%. While pushing the limits of performance is of major importance, we believe that there is a need for smaller and less complex systems that bring along a reduced cost.While low footprint and low-cost systems can make microSPECT available to more researchers, the ease of operation and calibration and low maintainance cost are additional factors that can facilitate the use of microSPECT in molecular imaging. In this paper, we simulate the performance of a microSPECT imager that combines high space-bandwidth detectors and pinholes with truncated projection, resulting in a small and stationary system. Methods:A system optimization algorithm is used to determine the optimal SPECT systems, given our high resolutions detectors and a fixed field-of-view. These optimal system geometries are then used to simulate of a Defrise disk phantom, a hot rod phantom. Finally, a MOBY mouse phantom, with realistic concentrations of Tc99m-tetrofosmin is simulated.Results: Results show that we can successfully reconstruct a Defrise disk phantom of 24 mm in diameter without any rotating system components or translation of the object. Reconstructed spatial resolution is approximately 800 µm while the peak sensitivity 0.23%. Finally, the simulation of the MOBY mouse phantom shows that we can accurately reconstruct mouse images. Conclusions:These results show that pinholes with truncated projections can be used in small magnification or minification mode to obtain a compact and stationary microSPECT system. We showed that we can reach state-of-the-art system performance and that we can successfully reconstruct images with realistic noise levels in a pre-clinical context. Such a system can be useful for dynamic SPECT imaging. * Roel.VanHolen@UGent.be 2

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“…Recent advance of SPECT has been focused on development of multi-camera SPECT system for small animal imaging with large detection efficiency while maintaining high spatial resolution [3][4][5] . The multi-camera SPECT system usually requires high-resolution compact gamma camera module.…”

Section: Introductionmentioning

confidence: 99%

Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method

et al. 2010

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. (2010). Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method. Chinese Physics C, 34 (8), 1148-1152. Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method AbstractThe objective of this study is to investigate a high performance and lower cost compact gamma camera module for a multi-head small animal SPECT system. A compact camera module was developed using a thin Lutetium Oxyorthosilicate (LSO) scintillation crystal slice coupled to a Hamamatsu H8500 position sensitive photomultiplier tube (PSPMT). A two-stage charge division readout board based on a novel sub-tractive resistive readout with a truncated center-of-gravity (TCOG) positioning method was developed for the camera. The performance of the camera was evaluated using a flood 99mTc source with a four-quadrant barmask phantom. The preliminary experimental results show that the image shrinkage problem associated with the conventional resistive readout can be effectively overcome by the novel subtractive resistive readout with an appropriate fraction subtraction factor. The response output area (ROA) of the camera shown in the flood image was improved up to 34%, and an intrinsic spatial resolution better than 2 mm of detector was achieved.In conclusion, the utilization of a continuous scintillation crystal and a flat-panel PSPMT equipped with a novel subtractive resistive readout is a feasible approach for developing a high performance and lower cost compact gamma camera. Abstract The objective of this study is to investigate high performance and lower cost compact gamma camera module for multi-head small animal SPECT system. A compact camera module was developed using a thin Lutetium Oxyorthosilicate (LSO) scintillation crystal slice coupled to a Hamamatsu H8500 position sensitive photomultiplier tube (PSPMT). A two-stage charge division readout board based on novel subtractive resistive readout with truncated center-of-gravity (TCOG) positioning method was developed for the camera. The performance of the camera was evaluated using a flood 99mTc source with four-quadrant bar-mask phantom. The preliminary experimental results show that the image shrinkage problem associated with the conventional resistive readout can be effectively overcome by the novel subtractive resistive readout with an appropriate fraction subtraction factor, the response output area (ROA) of camera shown in the flood image was improved up to 34%, and an intrinsic spatial resolution better than 2mm of detector was achieved. In conclusion, the utilization of continuous scintillation crystal and flat-panel PSPMT equipped with the novel subtractive resistive readout is a feasible approach for development of high performance and lower cost compact gamma camera.

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FastSPECT II: a second-generation high-resolution dynamic SPECT imager

Cited by 198 publications

References 8 publications

Fast iterative reconstruction for helical pinhole SPECT imaging

Fast iterative reconstruction for helical pinhole SPECT imaging

Design and performance of a compact and stationary microSPECT system

Investigation of high resolution compact gamma camera module based on a continuous scintillation crystal using a novel charge division readout method

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