Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions

Li, Wenyuan; Shu, Shan; Cheng, Lele; Xiang, Hao; Wang, Lijun; Wu, Yue; Yuan, Zuyi; Zhou, Juan

doi:10.1016/j.atherosclerosis.2019.11.026

Cited by 55 publications

(46 citation statements)

References 34 publications

(46 reference statements)

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“…Bile acids function as emulsifiers to help digest and uptake lipids and fat-soluble vitamins, but also serve as signaling molecules for modulating metabolism and inflammation 56 . High levels of bile acids interfere with blood brain barrier integrity and act as direct cytotoxic agents 23,57,58 . It is possible that CA-induced global injury and the resulting diminished physiologic and metabolic processes may result in altered bile acid concentration in the plasma, which may be a potential mediator of reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

Shoaib

Choudhary

Choi

et al. 2020

Sci Rep

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Cardiac arrest (CA) is a leading cause of death and there is a necessity for animal models that accurately represent human injury severity. We evaluated a rat model of severe CA injury by comparing plasma metabolic alterations to human patients. Plasma was obtained from adult human control and CA patients post-resuscitation, and from male Sprague–Dawley rats at baseline and after 20 min CA followed by 30 min cardiopulmonary bypass resuscitation. An untargeted metabolomics evaluation using UPLC-QTOF-MS/MS was performed for plasma metabolome comparison. Here we show the metabolic commonality between humans and our severe injury rat model, highlighting significant metabolic dysfunction as seen by similar alterations in (1) TCA cycle metabolites, (2) tryptophan and kynurenic acid metabolites, and (3) acylcarnitine, fatty acid, and phospholipid metabolites. With substantial interspecies metabolic similarity in post-resuscitation plasma, our long duration CA rat model metabolically replicates human disease and is a suitable model for translational CA research.

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Section: Discussionmentioning

confidence: 99%

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

Shoaib

Choudhary

Choi

et al. 2020

Sci Rep

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“…A wide variety of bacterial derivative metabolites have been shown to module vascular pathophysiology, including trimethylamine-N-oxide (TMAO), short-chain fatty acids (SCFAs) and bile acids (BAs) [ 1 , 2 ]. Cohort studies in diverse populations have demonstrated that bile acids may be a useful biomarker to predict the severity of CVD [ 3 , 4 ]. Bile acids are synthesized from cholesterol in the liver via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1).…”

Section: Introductionmentioning

confidence: 99%

“…(BAs) [1,2]. Cohort studies in diverse populations have demonstrated that bile acids may be a useful biomarker to predict the severity of CVD [3,4]. Bile acids are synthesized from cholesterol in the liver via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1).…”

mentioning

confidence: 99%

Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation

et al. 2020

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Background The gut microbiota was shown to play a crucial role in the development of vascular dysfunction, and the bacterial composition differed between healthy controls and coronary artery disease patients. The goal of this study was to investigate how the gut microbiota affects host metabolic homeostasis at the organism scale. Methods We colonized germ-free C57BL/6 J mice with faeces from healthy control donors (Con) and coronary artery disease (CAD) patients and fed both groups a high fat diet for 12 weeks. We monitored cholesterol and vascular function in the transplanted mice. We analysed bile acids profiles and gut microbiota composition. Transcriptome sequencing and flow cytometry were performed to evaluate inflammatory and immune response. Results CAD mice showed increased reactive oxygen species generation and intensive arterial stiffness. Microbiota profiles in recipient mice clustered according to the microbiota structure of the human donors. Clostridium symbiosum and Eggerthella colonization from CAD patients modulated the secondary bile acids pool, leading to an increase in lithocholic acid and keto-derivatives. Subsequently, bile acids imbalance in the CAD mice inhibited hepatic bile acids synthesis and resulted in elevated circulatory cholesterol. Moreover, the faecal microbiota from the CAD patients caused a significant induction of abnormal immune responses at both the transcriptome level and through the enhanced secretion of cytokines. In addition, microbes belonging to CAD promoted intestinal inflammation by contributing to lamina propria Th17/Treg imbalance and worsened gut barrier permeability. Conclusions In summary, our findings elucidated that the gut microbiota impacts cholesterol homeostasis by modulating bile acids. In addition, the CAD-associated bacterial community was shown to function as an important regulator of systemic inflammation and to influence arterial stiffness.

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“…Thus, alterations of re-absorption and elimination of bile acids influence cholesterol homeostasis and the development of cardiovascular disease. Li et al [21] addressed the predictive value of TBA in serum for MI. They enrolled 7438 patients admitted with angina-like symptoms, of whom 78.7% were subsequently diagnosed with coronary artery disease (CAD), and 28.4% were diagnosed with MI.…”

Section: Lipid-related Biomarkers Beyond Cholesterol and Triglyceridesmentioning

confidence: 99%

The year 2020 in Atherosclerosis

Binder¹,

Borén²,

Catapano³

et al. 2021

Atherosclerosis

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Fasting serum total bile acid level is associated with coronary artery disease, myocardial infarction and severity of coronary lesions

Cited by 55 publications

References 34 publications

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations

Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation

The year 2020 in Atherosclerosis

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