Fasting activates neuropeptide Y neurons in the arcuate nucleus and the paraventricular nucleus in the rhesus macaque

Grove, Kevin L.; Chen, Peilin; Koegler, Frank H.; Schiffmaker, Andrew; Smith, M. Susan; Cameron, Judy L.

doi:10.1016/s0169-328x(03)00093-7

Cited by 41 publications

(21 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While CART mRNA distribution in the NHP brain has not been reported previously, these observations are in agreement with CART peptide immunoreactivity in the soma of cells in the PVN and ARC of humans and NHPs [31, 32]. We detected significant numbers of NPY mRNA-positive cells in the SON, PVN, and ARC as reported collectively in three publications [8, 25, 33]. Ob-R mRNA was highly expressed in the ARC and VMN in agreement with the only other published study of Ob-R distribution in the NHP [8].…”

Section: Discussionsupporting

confidence: 92%

“…These results partially agree with the only other study to examine the effect of fasting on NPY expression in NHPs [25]. Both primate studies documented similar levels of NPY expression in the ARC and SON.…”

Section: Discussionsupporting

confidence: 89%

“…Intracerebroventricular NPY administration stimulated food intake and inhibited LH secretion whereas melanocortin receptor agonists inhibited food intake and stimulated LH secretion in rhesus monkeys [16, 20, 23, 24]. A 48-hour fast stimulated NPY gene expression in the ARC and PVN [25] and inhibited POMC gene expression in the ARC of rhesus monkeys [24]. Leptin administration produced a delayed inhibition of food intake and reversed fasting-induced inhibition of LH secretion in peripubertal male monkeys [8, 26].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of Fasting on Cocaine-Amphetamine-Regulated Transcript, Neuropeptide Y, and Leptin Receptor Expression in the Non-Human Primate Hypothalamus

Vugt

Lujan²,

Froats³

et al. 2006

Neuroendocrinology

View full text Add to dashboard Cite

Leptin is a cytokine produced by white adipose tissue that circulates in direct proportion to adiposity and is an important signal of energy balance. Leptin inhibits food intake in rodents by inhibiting the orexigenic neuropetides neuropeptide Y (NPY) and agouti regulated peptide (AgRP) and stimulating the anorexigenic neuropeptides α-melanocyte-stimulating hormone (α-MSH) and cocaine-amphetamine-regulated transcript (CART). In order to extend our understanding of neuroendocrine regulation of appetite in the primate, we determined the effect of a metabolic challenge on CART, NPY, and leptin receptor (Ob-R) messenger ribonucleic acid (mRNA) in the nonhuman primate (NHP) hypothalamus. Ten adult female rhesus monkeys were either maintained on a regular diet or fasted for two days before euthanasia. CART, NPY, and Ob-R mRNA were measured by in situ hybridization histochemistry (ISHH). A 2-day fast decreased CART expression in the ARC, increased NPY gene expression in the supraoptic nucleus (SON) and paraventricular nucleus (PVN), and increased Ob-R expression in the ventromedial nucleus (VMN). This is the first report that fasting inhibits CART expression and stimulates Ob-R expression in monkeys. Increased NPY expression in the SON and PVN, but not the ARC of fasted monkeys also is novel. With some exceptions, our observations are confirmatory of findings in rodent studies. Similarities in the neuroendocrine responses to a metabolic challenge in monkeys and rodents support extending existing hypotheses of neuroendocrine control of energy homeostasis to primates.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Fasting on Cocaine-Amphetamine-Regulated Transcript, Neuropeptide Y, and Leptin Receptor Expression in the Non-Human Primate Hypothalamus

Vugt

Lujan²,

Froats³

et al. 2006

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…A trend was present in the ME and no effect of nutrition on NPY-ir was noted in the POA or the mHB. In rat and rhesus monkey brains fasting for 2-3 days elevated NPY immunoreactivity or mRNA consistently in the ARC and PVN (Grove et al, 2003;Sahu et al, 1988). Interestingly, in the male rat PVN, NPY-ir decreased to ad libitum levels one day, but not 6 hours, after the fast ended (Beck et al, 1990;Sahu et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…NPY is widely distributed within vertebrate species as its presence in the brain and role in stimulating food intake has been confirmed in various vertebrates from fish to humans (Allen et al, 1983;Crespi, Vaudry, and Denver, 2004;Goldstone, 2006;Grove, Chen, Koegler, Schiffmaker, Susan Smith, and Cameron, 2003;Inui, Okita, Nakajima, Inoue, Sakatani, Oya, Morioka, Okimura, Chihara, and Baba, 1991;Kuenzel, Douglass, and Davison, 1987;Morley, Hernandez, and Flood, 1987;Volkoff, Canosa, Unniappan, Cerda-Reverter, Bernier, Kelly, and Peter, 2005). While the function of NPY has been extensively studied in a few temperate zone mammals, to our knowledge no data have been collected in tropical or semi-tropical mammals which have less predictable food supplies and as such may have differences in neuropeptide regulation of appetite and feeding.…”

Section: Introductionmentioning

confidence: 99%

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Bojkowska

Hamczyk

Tsai

et al. 2008

Hormones and Behavior

View full text Add to dashboard Cite

Neuropeptide Y (NPY) stimulates feeding, depresses sexual behavior, and its expression in the brain is modulated by energetic status. We examined the role of NPY in female musk shrews, a species with high energetic and reproductive demands; they store little fat, and small changes in energy can rapidly diminish or enhance sexual receptivity. Intracerebroventricular infusion of NPY enhanced acute food intake in shrews, however, NPY had little affect on sexual receptivity. The distribution of NPY immunoreactivity in the female musk shrew brain was unremarkable, but energy status differentially affected NPY immunoreactivity in several regions. Similar to what has been noted in other species, NPY immunoreactivity was less dense in brains of ad libitum shrews and greater in shrews subjected to food restriction. In two midbrain regions, both of which contain high levels of gonadotropin releasing hormone II (GnRH II) which has anorexigenic actions in shrews, NPY immunoreactivity was more sensitive to changes in food intake. In these regions, acute refeeding (90-180 minutes) after food restriction reduced NPY immunoreactivity to levels noted in ad libitum shrews. We hypothesize that interactions between NPY and GnRH II maintain energy homeostasis and reproduction in the musk shrew.

show abstract

Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats

Jung

Kang

Suh

et al. 2008

Phytotherapy Research

View full text Add to dashboard Cite

To investigate the appetite regulation mechanism of low and high molecular weight yeast hydrolysate, neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) expressions were analyzed in the brains on rats using immunohistochemical method; normal diet (control), 0.1 g/kg (BY-1) or 1.0 g/kg (BY-2) of yeast hydrolysate below 10 kDa, 0.1 g/kg (AY-1) or 1.0 g/kg (AY-2) of yeast hydrolysate of 10-30 kDa. Body weight gain was lower in the BY-2 (133.0 g) than in the control (150.1 g) (p < 0.05). Triacylglyceride, total cholesterol, and LDL-cholesterol levels were lower in the BY-2 as compared to control, BY-1 and AY-2 (p < 0.05). NPY staining intensities at paraventricular nucleus (PVN) were lower in the BY groups (BY-1: 96.1, BY-2: 88.6) as compared to the control (105.6) and AY groups (AY-1: 110.5, AY-2: 114.1) (p < 0.05). NPY expression at lateral hypothalamic area (LHA) was lower in the BY-2 (92.3) than in the control (98.9) (p < 0.05). The BY groups (BY-1: 143.9, BY-2: 154.6) had higher TPH staining intensities at dorsal raphe (DR) than the AY-2 (115.9) (p < 0.05). In conclusion, the results indicate that administering yeast hydrolysate of below 10 kDa to normal diet-fed rats reduced body weight gain and serum lipids by altering NPY and TPH expressions.

show abstract

Fasting activates neuropeptide Y neurons in the arcuate nucleus and the paraventricular nucleus in the rhesus macaque

Cited by 41 publications

References 25 publications

Effect of Fasting on Cocaine-Amphetamine-Regulated Transcript, Neuropeptide Y, and Leptin Receptor Expression in the Non-Human Primate Hypothalamus

Effect of Fasting on Cocaine-Amphetamine-Regulated Transcript, Neuropeptide Y, and Leptin Receptor Expression in the Non-Human Primate Hypothalamus

Neuropeptide Y influences acute food intake and energy status affects NPY immunoreactivity in the female musk shrew (Suncus murinus)

Effects of yeast hydrolysate on neuropeptide Y (NPY) and tryptophan hydroxylase (TPH) immunoreactivity in rats

Contact Info

Product

Resources

About