Fast removal of the antibiotic flumequine from aqueous solution by ozonation: Influencing factors, reaction pathways, and toxicity evaluation

Feng, Mingbao; Yan, Liqing; Zhang, Xiaoling; Sun, Ping; Yang, Shaogui; Wang, Liansheng; Wang, Zunyao

doi:10.1016/j.scitotenv.2015.09.048

Cited by 82 publications

(22 citation statements)

References 47 publications

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“…The impact of the inorganic ions (chloride, sulphate and bicarbonate, potassium, calcium and magnesium) or extracts of NOM, and the type of water matrices (ultrapure, river water, influent and effluent wastewaters) on the removal of flumequine by ozonation, has been shown to be insignificant [90]. However, rice straw and pig manure NOM extracts, promoted the oxidation of the target pollutant [90]. The scavenging of NOM and carbonate/bicarbonate on HO • in different water matrices containing similar DOC and bicarbonate contents demonstrated different DOM reactivity [13].…”

Section: Ozone-based Processesmentioning

confidence: 99%

“…[89] The different ions and types of water (UPW, river water, WW influent and effluent) did not influenced the reaction efficiency significantly. However, the DOM extract composed by river sediment behaved as inhibitor and two DOM extracts, namely rice straw and pig manure, promoted the oxidation of the target pollutants [90] -Effect of inorganic ions (Cl -, SO4 2-, HCO3 -, K + , Ca 2+ , Mg 2+ ) or extracts of DOM (HA, rice straw, river sediment, pig manure).…”

Section: Photo-fenton O3/h2o2mentioning

confidence: 99%

“…NOM and carbonate/bicarbonate ions interfere with the rate of O3 decomposition depending on their concentrations and pH, affecting the yield of HO •[157]. Besides the scavenging effect of HO • by NOM[13,23,87,[90][91][92][93][94][95] and carbonate/bicarbonate[13,92,93,97,98], other anions (e.g., chloride, phosphate, sulphate) can also act as ozonation inhibitors[97,98].The main mechanism of O3 decomposition and generation of HO • in wastewater is the direct reaction with specific reactive moieties of the NOM (e.g., phenolic, amino and olefinic groups), considering that the initiation step of the radical chain reaction between O3 and hydroxide anions…”

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confidence: 99%

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Impact of water matrix on the removal of micropollutants by advanced oxidation technologies

Ribeiro

Moreira

Puma

et al. 2019

Chemical Engineering Journal

409

110

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Micropollutants (MPs) in the aquatic compartments originate from many sources and particularly from the effluents of urban wastewater treatment plants (UWWTPs). Advanced oxidation technologies (AOTs) usually applied after biological processes, have recently emerged as effective tertiary treatments for the removal of MPs, but the oxidation rates of the single compounds may be largely affected by the constituent species of the water matrix. These species include dissolved organic matter and inorganic species (e.g., carbonate, bicarbonate, nitrite, sulphate, chloride). This review analyses the impact of such substances on common AOTs including photolysis, UV/H2O2, Fenton, photocatalysis, and ozone-based processes. The degradation efficiency of single MPs by AOTs results from the combined impact of the water matrix constituents, which can have neutral, inhibiting or promoting effect, depending on the process and the mechanism by which these water components react. Organic species can be either inhibitors (by light attenuation; scavenging effects; or adsorption to catalyst) or promoters (by originating reactive oxygen species (ROS) which enhance indirect photolysis; or by regenerating the catalyst). Inorganic species can also be either inhibitors (by scavenging effects; formation of radicals less active than hydroxyl radicals; iron complexation; adsorption to catalyst or decrease 2 of its effective surface area) or promoters (e.g., nitrate ions by formation of ROS; iron ions as additional source of catalyst). The available data reviewed here is limited and the role and mechanisms of individual water components are still not completely understood. Further studies are needed to elucidate the wide spectrum of reactions occurring in complex wastewaters and to increase the adoption of AOTs in UWWTPs.

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Section: Ozone-based Processesmentioning

confidence: 99%

Section: Photo-fenton O3/h2o2mentioning

confidence: 99%

mentioning

confidence: 99%

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Impact of water matrix on the removal of micropollutants by advanced oxidation technologies

Ribeiro

Moreira

Puma

et al. 2019

Chemical Engineering Journal

409

110

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“…Activating the reduced cytochrome detoxification may be an important point in FQAD patients. On the other hand, ozonation has been described to be an effective method for removing the first generation FQ—flumequine from the liquid water [110]. Thus, ozone therapy can be examined to be a method of FQ degradation in the body.…”

Section: Therapeutic Conclusionmentioning

confidence: 99%

Treatment of the Fluoroquinolone‐Associated Disability: The Pathobiochemical Implications

Michalak

Sobolewska-Włodarczyk

Włodarczyk

et al. 2017

Oxidative Medicine and Cellular Longevity

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Long-term fluoroquinolone-associated disability (FQAD) after fluoroquinolone (FQ) antibiotic therapy appears in recent years as a significant medical and social problem, because patients suffer for many years after prescribed antimicrobial FQ treatment from tiredness, concentration problems, neuropathies, tendinopathies, and other symptoms. The knowledge about the molecular activity of FQs in the cells remains unclear in many details. The effective treatment of this chronic state remains difficult and not effective. The current paper reviews the pathobiochemical properties of FQs, hints the directions for further research, and reviews the research concerning the proposed treatment of patients. Based on the analysis of literature, the main directions of possible effective treatment of FQAD are proposed: (a) reduction of the oxidative stress, (b) restoring reduced mitochondrion potential ΔΨm, (c) supplementation of uni- and bivalent cations that are chelated by FQs and probably ineffectively transported to the cell (caution must be paid to Fe and Cu because they may generate Fenton reaction), (d) stimulating the mitochondrial proliferation, (e) removing FQs permanently accumulated in the cells (if this phenomenon takes place), and (f) regulating the disturbed gene expression and enzyme activity.

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“…solutions [8,[33][34][35][36]. Other studies have used photocatalysis to successfully degrade Flumequine [37][38][39][40][41].…”

Section: Recent Studies Have Demonstrated the Feasibility Of Flumequimentioning

confidence: 99%

Study of a photocatalytic process for removal of antibiotics from wastewater in a falling film photoreactor: Scavenger study and process intensification feasibility

Lou¹,

Kane

Wolbert

et al. 2017

Chemical Engineering and Processing: Process Intensification

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International audienceThis study focused on the removal of antibiotic by coupling of heterogeneous photocatalysis with ozonation and hydrogen peroxide. The main objective was to intensify the efficiency of photocatalytic activity for better and faster antibiotic elimination/mineralization in wastewater. To fulfill this purpose a photocatalytic process based on falling film reactor was designed and optimized. The effects of operating parameters such as wastewater flow rate in the falling film reactor, the presence of an oxidizing agent (H2O2 and O3), inlet concentrations, including catalyst dosage and light intensity were investigated and discussed. Experiments were mainly conducted with Flumequine and Clarithromycin. The first molecule (Flumequine) will serve as an example of fluoroquinolone antibiotics and the second (Clarithromycin) as an example of macrolide antibiotics. Experimentally, the results have shown interesting degradation and mineralization efficiency (on the order of 94% for degradation and 76% for mineralization). Evidence for redox catalysis was shown using X-ray photoelectron spectroscopy (XPS) before and after pollutant degradation. Moreover, special attention was also paid to identify the reaction products and the plausible degradation pathway during Flumequine degradation

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Fast removal of the antibiotic flumequine from aqueous solution by ozonation: Influencing factors, reaction pathways, and toxicity evaluation

Cited by 82 publications

References 47 publications

Impact of water matrix on the removal of micropollutants by advanced oxidation technologies

Impact of water matrix on the removal of micropollutants by advanced oxidation technologies

Treatment of the Fluoroquinolone‐Associated Disability: The Pathobiochemical Implications

Study of a photocatalytic process for removal of antibiotics from wastewater in a falling film photoreactor: Scavenger study and process intensification feasibility

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