Fast preparation of a hydrophobic monolith by redox initiation and its application in the separation of small molecules

Hao, Mengbei; Zhong, Jing; Ruo, LI; Li, Haijing; Bai, Ligai; Yang, Gengliang

doi:10.1039/c3ay41769g

Cited by 5 publications

(3 citation statements)

References 30 publications

(25 reference statements)

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“…As shown in Figure (a), seven aromatic compounds were baseline separated with the highest column efficiency of 21 000 plates per meter calculated by benzene (detail chromatographic parameters were listed in Supporting Information Table S1). Though, as we know, it was a challenge to improve the column efficiency of polymer monolith in separation of small molecules, especially for column with 4.6 mm i.d., compared to our previous work prepared by redox initiation with the highest column efficiency of 11,000 plates per meter, the present method had improved column efficiency.…”

Section: Resultsmentioning

confidence: 55%

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

Jiang

Jiao

Zhang

et al. 2017

J of Applied Polymer Sci

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A polymer monolithic column was prepared via redox system in a stainless steel column (50 3 4.6 mm i.d.) by using 1,6hexanediol diacrylate as monomer and ethylene dimethacrylate as cross linking agent. Characteristics of the homemade monolithic column were investigated by scanning electron microscopy, nitrogen adsorption-desorption and mercury intrusion porosimeter, respectively. The results showed that the resulting monolithic column occupied relative uniform porous skeleton structure. Furthermore, the monolith was tested by separating aromatic compounds in conjunction of high performance liquid chromatography with the highest column efficiency of more than 21,000 plate per meter, which was relative high for polymer-based monolithic column with 4.6 mm i.d. At last, the monolithic column was used to simultaneously separate and quantitatively analyzes five active compounds in Chinese herb Rheum palmatum L. The validation of the method was carried out, which indicated that the accuracy represented by recovery was in the range of 98.48% to 101.57%. Limit of detection and limit of quantification for the five active compounds were less than 33.7 ng and 90.8 ng, respectively. All the results indicated that the present method was simple and efficient for quantitative analysis of the five active compounds from Chinese herb Rheum palmatum L.

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Section: Resultsmentioning

confidence: 55%

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

Jiang

Jiao

Zhang

et al. 2017

J of Applied Polymer Sci

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“…Butyl methacrylate, lauryl methacrylate, and so on were the typical monomers used to separate small molecules, achieving about 15,000 plates per meter. Moreover, in our previous work, many polymer monolithic columns have been prepared using trimethylol propane triacrylate, 1‐dodecene, and so on as monomers. Nevertheless, the previous column efficiency was not satisfactory and could not separate the mixture of acidic, alkaline, and neutral compounds at the same time.…”

Section: Resultsmentioning

confidence: 99%

Fabrication of nanodiamond‐based composite monolithic column and its application in separation of small molecules

Wei

Liu

Wang

et al. 2016

J of Applied Polymer Sci

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A nanodiamond‐based composite monolithic column was fabricated by redox initiation for high‐performance liquid chromatography. In the fabrication process, functionalized nanodiamond was used as the functional monomer, dipentaerythritol hexaacrylate and 1,10‐decanediol diacrylate as cross‐linking agents, polyethylene glycol 400 and 1‐propanol as coporogens, and dibenzoyl peroxide and N,N‐dimethyl aniline as initiators. Compared to polymer monolithic columns without nanodiamond, a nanodiamond‐based composite monolithic column prepared under the same conditions exhibited relatively high resolution and efficiency. Characterizations of the resulting nanocomposite were carried out, including scanning electron microscopy, mercury intrusion porosimetry, nitrogen adsorption–desorption isotherm measurement, and thermogravimetric analysis. The ND‐based composite monolith exhibited a uniform and reticular skeleton microstructure, thermal stability, and mechanical stability. In addition, the nanodiamond‐based composite monolithic column was used to separate a series of small molecules with good resolution and reproducibility in high‐performance liquid chromatography. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43776.

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“…[1][2][3] Monoliths can be categorized into organic polymer-based and inorganic silica-based monoliths depending on the nature of the precursors used. 4 Polymer monoliths have good stability in a wide range of pH and have great exibility in tuning the chemical properties of monoliths by using various functional monomers, cross-linkers, an initiator and a porogen solvent. 5,6 There are increasing reports concerning polymer monoliths employed as the stationary phases because they possess unique structures.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applications for the separation of small molecules in high performance liquid chromatography

et al. 2015

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A novel porous polymer monolithic column was prepared by in situ free radical polymerization and used as a stationary phase for high performance liquid chromatography (HPLC). In this process, an ionic liquid (IL) was used as a porogen and reaction medium to create pores and enhance the flow-through properties of the polymer monoliths. The effect of IL in the polymerization mixture on the performance of the monoliths was studied in detail. The addition of IL can enhance the resolution and column efficiency compared to the monoliths with alcohol as the porogen. The chromatographic performance of the columns was demonstrated by the separation of various small molecules. The monolith exhibited a typical reversed phase chromatographic behavior with a column efficiency of 12 500 plates per m, which outperformed the commonly used porogen alcohol compounds. The results demonstrated that the IL was a potentially efficient porogen for the preparation of polymer monolithic columns. Moreover, the good mechanical stability, permeability, and reproducibility of column fabrication suggested that the proposed monolith can be expected to be an alternative tool for HPLC separation.

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Fast preparation of a hydrophobic monolith by redox initiation and its application in the separation of small molecules

Abstract: A novel skeleton hydrophobic polymeric monolith was prepared by redox initiation and used to separate a mixture of benzenes.

Cited by 5 publications

References 30 publications

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

Fabrication of a polymer monolithic column via redox system and its application in efficient separation of Chinese herb Rheum palmatumL.

Fabrication of nanodiamond‐based composite monolithic column and its application in separation of small molecules

Preparation of a porous polymer monolithic column with an ionic liquid as a porogen and its applications for the separation of small molecules in high performance liquid chromatography

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