Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner

Kim, Jin Young; Lee, Chang-Ho; Park, Kyungjin; Lim, Geunbae; Kim, Chulhong

doi:10.1038/srep07932

Cited by 165 publications

(113 citation statements)

References 24 publications

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“…Such a relay mechanism increases the size and cost of the OCT system. Another approach is to use twoaxis tilt mirrors [68,69], which use a single mirror to scan along both and directions. Using current technologies, generally, galvanometric mirrors provide more linear and faster scanning speeds compared to two-axis tilt mirrors.…”

Section: Galvanometric Mirrorsmentioning

confidence: 99%

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Atry

Rosa

Rarick

et al. 2018

International Journal of Optics

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In the past decades, spectral-domain optical coherence tomography (SD-OCT) has transformed into a widely popular imaging technology which is used in many research and clinical applications. Despite such fast growth in the field, the technology has not been readily accessible to many research laboratories either due to the cost or inflexibility of the commercially available systems or due to the lack of essential knowledge in the field of optics to develop custom-made scanners that suit specific applications. This paper aims to provide a detailed discussion on the design and development process of a typical SD-OCT scanner. The effects of multiple design parameters, for the main optical and optomechanical components, on the overall performance of the imaging system are analyzed and discussions are provided to serve as a guideline for the development of a custom SD-OCT system. While this article can be generalized for different applications, we will demonstrate the design of a SD-OCT system and representative results for in vivo brain imaging. We explain procedures to measure the axial and transversal resolutions and field of view of the system and to understand the discrepancies between the experimental and theoretical values. The specific aim of this piece is to facilitate the process of constructing custom-made SD-OCT scanners for research groups with minimum understanding of concepts in optical design and medical imaging.

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Section: Galvanometric Mirrorsmentioning

confidence: 99%

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Atry

Rosa

Rarick

et al. 2018

International Journal of Optics

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“…In acoustic-resolution PAM (ARPAM), high lateral resolution is enabled by acoustic focusing [10][11][12]. To further enhance the lateral resolution, optical-resolution PAM (ORPAM) employs tight optical focusing to realize resolution up to several micrometers or even a sub-micrometer scale [3,13,14]. In both types, high axial resolution is achieved by utilizing the wideband response to detect a short acoustic pulse.…”

Section: Introductionmentioning

confidence: 99%

In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions

Cai¹,

Li²,

Chen³

2016

Biomed. Opt. Express

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Acoustic-resolution photoacoustic microscopy (ARPAM) provides a spatial resolution on the order of tens of micrometers, and is becoming an essential tool for imaging fine structures, such as the subcutaneous microvasculature. High lateral resolution of ARPAM is achieved using high numerical aperture (NA) of acoustic transducer; however, the depth of focus and working distance will be deteriorated correspondingly, thus sacrificing the imaging range and accessible depth. The axial resolution of ARPAM is limited by the transducer's bandwidth. In this work, we develop deconvolution ARPAM (D-ARPAM) in three dimensions that can improve the lateral resolution by 1.8 and 3.7 times and the axial resolution by 1.7 and 2.7 times, depending on the adopted criteria, using a 20-MHz focused transducer without physically increasing its NA and bandwidth. The resolution enhancement in three dimensions by D-ARPAM is also demonstrated by in vivo imaging of the microvasculature of a chick embryo. The proposed D-ARPAM has potential for biomedical imaging that simultaneously requires high spatial resolution, extended imaging range, and long accessible depth.

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“…[29][30][31][32][33][34][35] The spatial resolution and sensitivity of the imaging systems depend on the laser excitation and acoustic detection con¯gurations. Like PAM, PAE is emerging as a novel technology for imaging internal organs with longer depth.…”

Section: Introductionmentioning

confidence: 99%

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

Yao

Ding

Liu

et al. 2017

J. Innov. Opt. Health Sci.

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Photoacoustic imaging, an emerging biomedical imaging modality, holds great promise for preclinical and clinical researches. It combines the high optical contrast and high ultrasound resolution by converting laser excitation into ultrasonic emission. In order to generate photoacoustic signal e±-ciently, bulky Q-switched solid-state laser systems are most commonly used as excitation sources and hence limit its commercialization. As an alternative, the miniaturized semiconductor laser system has the advantages of being inexpensive, compact, and robust, which makes a signi¯cant e®ect on production-forming design. It is also desirable to obtain a wavelength in a wide range from visible to nearinfrared spectrum for multispectral applications. Focussing on practical aspect, this paper reviews the state-of-the-art developments of low-cost photoacoustic system with laser diode and light-emitting diode excitation source and highlights a few representative installations in the past decade.

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Fast optical-resolution photoacoustic microscopy using a 2-axis water-proofing MEMS scanner

Cited by 165 publications

References 24 publications

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

Design and Implementation Guidelines for a Modular Spectral-Domain Optical Coherence Tomography Scanner

In vivo deconvolution acoustic-resolution photoacoustic microscopy in three dimensions

Low-cost photoacoustic imaging systems based on laser diode and light-emitting diode excitation

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