Fast LC–MS Electrospray Ionization for the Quantification of Digoxin in Human Plasma and Its Application to Bioequivalence Studies

Simultaneous quantification of digoxin, digitoxin, and their metabolites in serum using high performance liquid chromatography‐tandem mass spectrometry

“…Additionally, the method was also directed at semi-quantitative analysis of deslanoside and lanatoside. Several individual liquid chromatography-mass spectrometry (LC-MS) assays for digoxin and digitoxin [20][21][22][23][24][25][26][27][28][29][30] have been reported as well as in combination with their metabolites or related cardiac glycosides. [19,[31][32][33][34][35] To our knowledge, no LC-MS/MS method has been described for simultaneous quantification of the above combination of drugs and their metabolites.…”