Clinical applications of fast liquid chromatography: A review on the analysis of cardiovascular drugs and their metabolites

Baranowska, Irena; Magiera, Sylwia; Baranowski, J. M.

doi:10.1016/j.jchromb.2013.02.002

Cited by 27 publications

(10 citation statements)

References 182 publications

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“…Levando-se em conta que os fatores responsáveis pela alteração do tempo de retenção de um composto são composição da fase móvel, afinidade do analito pela fase estacionária e tipo de eluição empregada [10] , diferentes proporções entre os solventes foram utilizadas: ACN: H 2 O 40: 60, 50: 50, 60: 40 e 70: 30 (v/v), a fim de obterem-se resolução aceitável, picos simétricos e curto tempo de análise. A proporção escolhida foi ACN: H 2 O (40: 60 v/v).…”

Section: Resultsunclassified

“…Desse modo, em 2004 foi lançado o primeiro sistema de CLUE disponível no mercado (Waters Corporation), sendo possível encontrar vários nomes para essa técnica: resolução rápida, separação rápida e separação ultrarrápida [10] .…”

Section: Clae Clue E Cgunclassified

“…A CLUE, por sua vez, o reduz marcadamente em até 20 vezes, sem que isto comprometa a resolução [12][13][14] . Um benefício adicional da CLUE é o baixo consumo de fase móvel [10] .…”

Section: Clae Clue E Cgunclassified

“…Com a presença dessas pontes, a maioria dos grupos silanóis livres está protegida [15] , conferindo elevada estabilidade química ao longo de quase toda a faixa de pH (1 a 12), diminuição de interações secundárias indesejáveis com esses grupamentos [10] e maior estabilidade mecânica, por meio das ligações silício-carbono, que garante resistência a altas pressões [11] .…”

Section: Clae Clue E Cgunclassified

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Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Marques¹,

Oliveira²

2013

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Section: Resultsunclassified

Section: Clae Clue E Cgunclassified

“…A CLUE, por sua vez, o reduz marcadamente em até 20 vezes, sem que isto comprometa a resolução [12][13][14] . Um benefício adicional da CLUE é o baixo consumo de fase móvel [10] .…”

Section: Clae Clue E Cgunclassified

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Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Marques¹,

Oliveira²

2013

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“…For a better performance and organisation, a simultaneous approach has been undertaken. Several analytical methods for simultaneous determinations of cardiovascular drugs have been described in literature . Gergov et al developed an assay to monitor 238 therapeutic and illegal drugs in blood samples, only for the purpose of screening and establishing LODs .…”

Section: Introductionmentioning

confidence: 99%

Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs

Bernard

Akrout

Buu

et al. 2015

J of Separation Science

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The counterfeiting of pharmaceuticals has been detected since about 1990 and has alarmingly continued to pick up steam. We have been recently involved in an evaluation program of some of the most commonly prescribed cardiovascular drugs in Africa, for analysing an important number of tablets or capsules obtained from different places in seven African countries. A reversed-phase high-performance liquid chromatography with tandem mass spectrometry method was developed and validated to simultaneously control the identity and the quantity of acenocoumarol, amlodipine, atenolol, captopril, furosemide, hydrochlorothiazide and simvastatin in tablets. Their separation was performed on a Kinetex® C(18) (100 mm × 2.1 mm inside diameter, 2.6 μm) column using a gradient elution of 20 mM ammonium formate buffer and acetonitrile (90:10 10:90 v/v) at a flow rate of 0.5 mL/min. The analytes were detected using electrospray ionisation tandem mass spectrometry in both positive and negative modes with multiple reaction monitoring. Tandem mass spectrometry fragmentation patterns of captopril, furosemide and acenocoumarol, up to now not detailed in the literature, were also studied to assist in the selection of the most relevant transitions towards the objectives. The developed method was validated as per International Conference on Harmonisation guidelines with respect to specificity, linearity, trueness, precision, limits of detection and quantification. It has been successfully applied to the control of oral forms of seven cardiovascular drugs collected in African countries.

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Fast and Miniaturized Chromatography

Socas‐Rodríguez

Herrera‐Herrera

González‐Curbelo

et al. 2015

Analytical Separation Science

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This chapter provides a general overview of the different aspects, characteristics, and applications that involve the use of fast liquid chromatography (LC) and gas chromatography (GC) as well as the miniaturized versions of both techniques such as capillary/nano‐LC, micro‐GC, capillary electrochromatography (CEC), and chips. Moreover, the primary objective of the early use of GC techniques was to completely resolve multi‐component mixtures in complex matrices and the attention on analysis time was delayed. The chapter presents the current trends in fast LC separations, which involve monolith technologies, fused core columns, sub‐2 μm particles, high‐temperature liquid chromatography (HTLC), and ultrahigh‐performance liquid chromatography (UHPLC), as well as fast GC separations that can be basically achieved by the use of narrow‐bore columns, fast temperature programming, or low‐pressure gas chromatography (LPGC).

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Clinical applications of fast liquid chromatography: A review on the analysis of cardiovascular drugs and their metabolites

Cited by 27 publications

References 182 publications

Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs

Fast and Miniaturized Chromatography

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Clinical applications of fast liquid chromatography: A review on the analysis of cardiovascular drugs and their metabolites

Cited by 27 publications

References 182 publications

Técnicas cromatográficas e o desafio na determinação de ­compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Técnicas cromatográficas e o desafio na determinação de ­compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Liquid chromatography with tandem mass spectrometry for the simultaneous identification and quantification of cardiovascular drugs applied to the detection of substandard and falsified drugs

Fast and Miniaturized Chromatography

Contact Info

Product

Resources

About

Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina

Técnicas cromatográficas e o desafio na determinação de compostos presentes em matrizes complexas: Relato de um caso prático do produto natural piperlongumina