Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate

Curto, L.; Carnero, Ll.; López-Aventín, Daniel; Traveria, G.; Roura, G.; Giménez‐Arnau, Ana

doi:10.1111/jdv.12292

Cited by 14 publications

(7 citation statements)

References 25 publications

(45 reference statements)

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“…Pruritus experimentally induced by histamine was significantly suppressed by topical hydrocortisone when compared to placebo (201). In another experimental model itch relief from nickel allergy provided by methylprednisolone aceponate was very rapid and preceded resolution of all other eczema findings, suggesting a direct antipruritic effect of the agent rather than just an indirect anti-inflammatory one (202).…”

Section: Topical Glucocorticosteroidsmentioning

confidence: 94%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

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ActaDV is a journal for clinical and experimental research in the field of dermatology and venereology and publishes highquality papers in English dealing with new observations on basic dermatological and venereological research, as well as clinical investigations. Each volume also features a number of review articles in special areas, as well as Correspondence to the Editor to stimulate debate. New books are also reviewed. The journal has rapid publication times.

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Section: Topical Glucocorticosteroidsmentioning

confidence: 94%

European S2k Guideline on Chronic Pruritus

Weißhaar¹,

Szepietowski²,

Dalgard³

et al. 2019

Acta Derm Venerol

242

201

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“…Itching at the site of application of the patches is commonly observed; it can either be attributable to a positive patch test reaction, or be a result of tape irritation. However, some patients experience more itching immediately after removal of the tape . Various subjective complaints of patch tested patients have occasionally been reported in the literature .…”

Section: Potential Adverse Effects Of Patch Testingmentioning

confidence: 99%

European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice

et al. 2015

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SummaryThe present guideline summarizes all aspects of patch testing for the diagnosis of contact allergy in patients suspected of suffering, or having been suffering, from allergic contact dermatitis or other delayed-type hypersensitivity skin and mucosal conditions. Sections with brief descriptions and discussions of different pertinent topics are followed by a highlighted short practical recommendation. Topics comprise, after an introduction with important definitions, materials, technique, modifications of epicutaneous testing, individual factors influencing the patch test outcome or necessitating special considerations, children, patients with occupational contact dermatitis and drug eruptions as special groups, patch testing of materials brought in by the patient, adverse effects of patch testing, and the final evaluation and patient counselling based on this judgement. Finally, short reference is made to aspects of (continuing) medical education and to electronic collection of data for epidemiological surveillance.

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“…The quantification of biophysical parameters, such as TEWL, stratum corneum (SC) hydration, and skin surface pH, is necessary for the complete evaluation of the epidermal barrier status (Darlenski et al, 2009). Skin erythema and temperature measurement have been used as noninvasive ways to investigate inflammation (Curto et al, 2014, Kwon et al, 2014). Also, a strong association has been shown between ultrasound and pathological findings in other inflammatory skin diseases, such as atopic dermatitis (Polańska et al, 2013a, Polańska et al, 2013b).…”

Section: Introductionmentioning

confidence: 99%

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin

Yazdanparast

Yazdani

Humbert

et al. 2019

International Journal of Women's Dermatology

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Background Lichen planus (LP) is a chronic inflammatory disease of the skin. Currently, noninvasive techniques are used to evaluate biophysical properties of the skin in vivo. Objective In this study, we aimed to evaluate skin biophysical properties in patients with LP and make a comparison between involved and uninvolved skin to provide a better understanding of the pathogenesis of LP. Methods The stratum corneum hydration, transepidermal water loss, pH, erythema, melanin, sebum, friction, temperature, elasticity parameters (R0, R2, R5), and thickness and echo-density of the epidermis, dermis, and subepidermal low echogenic band were measured on lesions of classic LP in 21 patients and compared with the average of perilesional and symmetrical uninvolved skin (as control) with a paired t test. Results Stratum corneum hydration ( p = .002), sebum ( p = .04), R0 ( p = .005), and echo-density of the dermis ( p = .005) were significantly lower, but pH ( p = .007), melanin content ( p < .001), erythema ( p < .001), temperature ( p = .01), thickness of dermis ( p = .02), and subepidermal low echogenic band ( p < .001) were significantly higher in LP lesions. Conclusion An evaluation of its biophysical, biomechanical, and ultrasonographic characteristics showed that the skin is an objective, noninvasive, and quantitative measuring tool that can be used to provide valuable information about skin changes in classic LP.

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Fast itch relief in an experimental model for methylprednisolone aceponate topical corticosteroid activity, based on allergic contact eczema to nickel sulphate

Abstract: We present a valid model to assess the efficacy and speed of action of TC treatment to alleviate pruritus and the signs of eczema. The fast effect of MPA against pruritus supports the appropriateness of treating allergic contact eczema with TC.

Cited by 14 publications

References 25 publications

European S2k Guideline on Chronic Pruritus

European S2k Guideline on Chronic Pruritus

European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin

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