Fast enantioseparation of indole phytoalexins in additive free supercritical fluid chromatography

Kozlov, Oleksandr; Kalíková, Květa; Gondová, Taťána; Budovská, Mariana; Salayová, Aneta; Tesařová, Eva

doi:10.1016/j.chroma.2019.03.028

Cited by 14 publications

(4 citation statements)

References 45 publications

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“…Kozlov et al used intermediate sized fully porous particles (2.5µm) with a polysaccharide based stationary phases for the fast separations of 27 indole phytoalexins. [72] As is shown in Fig. 6, short columns (2cm) packed with 1.8µm particles allow very fast (<8s) achiral separations of 7 solutes with baseline resolution [18].…”

Section: Fully Porous Particlesmentioning

confidence: 98%

Advances in the limits of separation power in supercritical fluid chromatography

Broeckhoven¹

2022

TrAC Trends in Analytical Chemistry

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Section: Fully Porous Particlesmentioning

confidence: 98%

Advances in the limits of separation power in supercritical fluid chromatography

Broeckhoven¹

2022

TrAC Trends in Analytical Chemistry

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“…The majority of indole phytoalexins and their synthetic derivatives exhibit chirality [26,85]. Studies have demonstrated that chemically modifying the structure of indole phytoalexins results in increased antiproliferative activities compared to the original natural compounds [15,[86][87][88][89][90].…”

Section: Antiproliferative Effects Of Synthetic Analogues Of Indole P...mentioning

confidence: 99%

Anticancer Potential of Indole Phytoalexins and Their Analogues

Zigová,

Michalková,

Mojžiš

2024

Molecules

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Indole phytoalexins, found in economically significant Cruciferae family plants, are synthesized in response to pathogen attacks or stress, serving as crucial components of plant defense mechanisms against bacterial and fungal infections. Furthermore, recent research indicates that these compounds hold promise for improving human health, particularly in terms of potential anticancer effects that have been observed in various studies. Since our last comprehensive overview in 2016 focusing on the antiproliferative effects of these substances, brassinin and camalexin have been the most extensively studied. This review analyses the multifaceted pharmacological effects of brassinin and camalexin, highlighting their anticancer potential. In this article, we also provide an overview of the antiproliferative activity of new synthetic analogs of indole phytoalexins, which were synthesized and tested at our university with the aim of enhancing efficacy compared to the parent compound.

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“…V současné době jsou na trhu dostupné chirální kolony určené pro použití jak v obou chromatografických technikách, tak i přímo určené pro použití v SFC (cit. 45,54 ). Protože neexistuje žádný univerzální chirální selektor, který by byl schopen separovat enantiomery všech chirálních látek, vývoj nových CSF stále probíhá v akademické i komerční sféře.…”

Section: Chirální Stacionární Fázeunclassified

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

Kalíková¹,

Folprechtová²,

Kadlecová³

2022

Chem. Listy

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Chirality is an essential feature of nature as it is common for many biologically active compounds. The different biological effects of individual enantiomers in a chiral environment are generally known. Therefore, there is a need for fast, efficient, and robust methods for their separation, quantification, and purification, too. The easiest way is to use chromatographic methods utilizing chiral stationary phases. Sub/supercritical fluid chromatography has become popular in the field of enantioselective separations in various scopes and, in some cases, has become a method of the first choice. Therefore, this review article covers actual trends and possibilities of sub/supercritical fluid chromatography in enantioseparations. Ways to influence enantioselectivity of the separation system by column coupling, screening approaches, and processes of methodical development for fast and efficient analyses are discussed. Sub/supercritical fluid chromatography under suitable experimental conditions provides fast and highly efficient separation of chiral compounds.

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Fast enantioseparation of indole phytoalexins in additive free supercritical fluid chromatography

Cited by 14 publications

References 45 publications

Advances in the limits of separation power in supercritical fluid chromatography

Advances in the limits of separation power in supercritical fluid chromatography

Anticancer Potential of Indole Phytoalexins and Their Analogues

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

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