Advances in the limits of separation power in supercritical fluid chromatography

Broeckhoven, Ken

doi:10.1016/j.trac.2021.116489

Cited by 6 publications

(6 citation statements)

References 84 publications

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“…Another UHPLC trend, the use of superficially porous particles with a solid core coated with a thin, porous layer of a stationary phase, has not yet been fully adopted in SFC. Although these particles provide higher separation efficiency and exhibit lower pressure than fully porous particles, their use is still negligible due to the extra-column dispersion [8,[145][146][147].…”

Section: Packed Sfc Columns In Analytical-scalementioning

confidence: 99%

“…Pure supercritical fluids, such as nitrous oxide, butane, and n-pentane, with pressure or density gradients, were used to separate nonpolar alkanes and aromatic homologs in petrochemistry and also in the analysis of polymers and surfactants. Despite the many successful and unique applications, at that time, SFC was considered only an extension of GC [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…The current systems are compatible with most modern stationary phases packed with fully porous particles < 2.0 μm and with core-shell particles. However, the advantage brought by the sub-2 μm particles and coreshell particles, that is, high efficiency of separations, is not fully exploited in UHPSFC as it is severely hindered by extensive extra-column volumes of the system [1,8,14,15]. Other often discussed drawbacks of current instrumentation include a pressure limitation of the systems and an impossibility of ternary gradient, that is for example, a gradient of water in an organic modifier.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Plachká

Pilařová

Horáček

et al. 2023

J of Separation Science

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Within this review, we thoroughly explored supercritical fluid chromatography (SFC) columns used across > 3000 papers published from the first study carried out under SFC conditions in 1962 to the end of 2022. We focused on the open tubular capillary, packed capillary, and packed columns, their chemistries, dimensions, and trends in used stationary phases with correlation to their specific interactions, advantages, drawbacks, used instrumentation, and application field. Since the 1990s, packed columns with liquid chromatography and SFC‐dedicated stationary phases for chiral and achiral separation are predominantly used. These stationary phases are based on silica support modified with a wide range of chemical moieties. Moreover, numerous unconventional stationary phases were evaluated, including porous graphitic carbon, titania, zirconia, alumina, liquid crystals, and ionic liquids. The applications of unconventional stationary phases are described in detail as they bring essential findings required for further development of the supercritical fluid chromatography technique.

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Section: Packed Sfc Columns In Analytical-scalementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Plachká

Pilařová

Horáček

et al. 2023

J of Separation Science

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show abstract

“…1. Směsná aditiva se, v rámci úspory času, velmi často využívají pro screeningové účely 22,44 možností je využití vody jako aditiva, což se ukázalo výhodné zejména při separaci chirálních polárních analytů na hydrofilních CSF z hlediska zvýšení účinnosti a snížení doby analýzy [51][52][53] .…”

Section: Mobilní Fáze Pro Separace Chirálních Sloučeninunclassified

“…v UHPSFC je podstatně menší než v technice ultra-vysokoúčinné kapalinové chromatografie (UHPLC). Na komerčně dostupných SFC přístrojích zatím není možné plně využít potenciál těchto vysoce účinných kolon s malým vnitřním rozměrem z důvodu významných mimokolonových příspěvků k rozšiřování píků, a tudíž nižší separační účinnosti 53,[65][66][67] . V literatuře jsou popsány různé laboratorní úpravy komerčních přístrojů (např.…”

Section: Chirální Stacionární Fázeunclassified

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

Kalíková¹,

Folprechtová²,

Kadlecová³

2022

Chem. Listy

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Chirality is an essential feature of nature as it is common for many biologically active compounds. The different biological effects of individual enantiomers in a chiral environment are generally known. Therefore, there is a need for fast, efficient, and robust methods for their separation, quantification, and purification, too. The easiest way is to use chromatographic methods utilizing chiral stationary phases. Sub/supercritical fluid chromatography has become popular in the field of enantioselective separations in various scopes and, in some cases, has become a method of the first choice. Therefore, this review article covers actual trends and possibilities of sub/supercritical fluid chromatography in enantioseparations. Ways to influence enantioselectivity of the separation system by column coupling, screening approaches, and processes of methodical development for fast and efficient analyses are discussed. Sub/supercritical fluid chromatography under suitable experimental conditions provides fast and highly efficient separation of chiral compounds.

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Evolution of packed column SFC as a greener analytical tool for pharmaceutical analysis

Olesik

Bennett

2022

Separation Science and Technology

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Advances in the limits of separation power in supercritical fluid chromatography

Cited by 6 publications

References 84 publications

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Columns in analytical‐scale supercritical fluid chromatography: From traditional to unconventional chemistries

Sub/supercritical Fluid Chromatography for Chiral Compounds Analysis

Evolution of packed column SFC as a greener analytical tool for pharmaceutical analysis

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