Evolution of packed column SFC as a greener analytical tool for pharmaceutical analysis

Olesik, Susan V.; Bennett, Raffeal

doi:10.1016/b978-0-323-88487-7.00006-1

Cited by 3 publications

(2 citation statements)

References 119 publications

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“…Although the effects of "supercritical fluids" (SFs) were observed by Cagniard de la Tour in 1822 and their usefulness was described more than 50 years later by Hannay and Hogarth in 1879, the first application of this phenomenon in chromatography was not considered until almost 100 years later by Klesper and colleagues (10). In 1962, Klesper et al (11,12) described the separation of thermolabile porphyrin derivatives using supercritical chlorofluoromethane at pressures up to 14 MPa and temperatures from 150°C to 170°C.…”

Section: The (R-)evolution Of Sfcmentioning

confidence: 99%

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Krmar,

Svrkota,

Obradović

et al. 2024

Arhiv za farmaciju

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Initially employed primarily at a preparative scale for enantiomer separation of chiral drug candidates, Supercritical Fluid Chromatography (SFC) is nowadays extensively used in the analytical mode. Recent advances in SFC separation science have emphasized its potential for modern and environmentally friendly pharmaceutical analysis. The aim of this review is to provide a deeper insight into the main fundamental and practical aspects of the SFC technique in order to familiarize readers with its versatile nature and efficiency in creating sustainable chromatographic solutions. All considerations are made primarily in the context of the most widely used mode of operation - achiral SFC. In addition, recent applications of this promising technique are presented at the end of the article to further promote its use in pharmaceutical analytical practice.

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Section: The (R-)evolution Of Sfcmentioning

confidence: 99%

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Krmar,

Svrkota,

Obradović

et al. 2024

Arhiv za farmaciju

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“…In term of ecological friendliness, they do not have the same environmental impact. As an example, it is estimated that the organic solvent use in liquid chromatography is around 150 000 tons annually; taking into account solvent use and its disposal across all applications, this is representing 30 million metric tons [9]. In green chemistry the use of hazardous chemicals and the energy demand is reduced, thereby reducing waste and demand on diminishing resources.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam‐based P2RX7‐antagonists

Avigo,

Furman,

Ghinet

et al. 2023

Electrophoresis

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In this work, a preparative supercritical fluid chromatography (SFC) method was first developed to separate a series of chiral compounds evaluated as lactam‐based P2RX7 antagonists. Subsequently, high‐performance liquid chromatography, SFC, and capillary electrophoresis (CE) were comparatively investigated as QC tools to determine the enantiomeric purity of the separated isomers, including analytical performance and greenness. The screening of the best conditions was carried out in liquid and SFC on the nine derivatives and the amylose tris(3,5‐dimethylphenylcarbamate)‐based chiral stationary phase was found to be highly efficient. The same screening was carried out in CE and very different conditions, either in acidic or basic background electrolyte and different cyclodextrins used as chiral selectors, allowed the separation of six of the nine derivatives. 1‐((3,4‐Dichlorophenyl)carbamoyl)‐5‐oxopyrrolidine‐2‐carboxylic acid (compound 1) was chosen as a probe, and its semi‐preparative separation by SFC and enantiomeric verification using the three techniques are presented. Its limit of detection and limit of quantification are calculated for each method. Finally, the greenness of each quality control method was evaluated.

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Physicochemical characterization and evaluation of polarity influence in eutectic systems applied to drug solubility

Lorenzetti,

Samuelsen Lucea,

Feaño

et al. 2024

Journal of Molecular Liquids

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Evolution of packed column SFC as a greener analytical tool for pharmaceutical analysis

Cited by 3 publications

References 119 publications

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Leveraging the power of supercritical fluid chromatography for eco-conscious solutions in pharmaceutical analysis

Evaluation of greenness and analytical performances of separative methods for chiral separation of novel lactam‐based P2RX7‐antagonists

Physicochemical characterization and evaluation of polarity influence in eutectic systems applied to drug solubility

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