Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning

Illangakoon, Upulitha Eranka; Gill, Hardyal; Shearman, Gemma C.; Parhizkar, Maryam; Mahalingam, Sunthar; Chatterton, Nicholas P.; Williams, Gareth R.

doi:10.1016/j.ijpharm.2014.10.036

Cited by 148 publications

(102 citation statements)

References 50 publications

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“…Combining the observations of the down-shifted carbonyl stretching band in PVP monomer and the broadening in -NH/-OH stretching band of PCM molecules, it is suggested that hydrogen bond interactions are formed between the C=O group of the PVP monomer and the NH or OH groups of PCM; this is in agreement with previously reported literature (Illangakoon et al, 2014;Nair et al, 2001;Wang et al, 2002). In the fingerprint region of circa 900-700 cm -1 , triplet peaks were seen for pure PCM and PM 50% PCM-PVP.…”

Section: Interaction Assessment Using Atr-ftirsupporting

confidence: 91%

“…Finally we explore the role of direct interaction between the drug and polymer via the use of two API systems (caffeine and paracetamol) which, while nominally similar in terms of molecular weight, have very different levels of molecular interaction with PVP (Illangakoon et al, 2014). These APIs therefore provide a useful model for investigating the extent to which such interactions may play a role in miscibility, processing and performance.…”

Section: Introductionmentioning

confidence: 99%

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An investigation into the influence of drug–polymer interactions on the miscibility, processability and structure of polyvinylpyrrolidone-based hot melt extrusion formulations

Chan

Craig³

2015

International Journal of Pharmaceutics

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While hot melt extrusion is now established within the pharmaceutical industry, the prediction of miscibility, processability and structural stability remains a pertinent issue, including the issue of whether molecular interaction is necessary for suitable performance. Here we integrate the use of theoretical and experimental drug-polymer interaction assessment with determination of processability and structure of dispersions in two polyvinylpyrrolidone-based polymers (PVP and PVP vinyl acetate, PVPVA). Caffeine and paracetamol were chosen as model drugs on the basis of their differing hydrogen bonding potential with PVP. Solubility parameter and interaction parameter calculations predicted a greater miscibility for paracetamol, while ATR-FTIR confirmed the hydrogen bonding propensity of the paracetamol with both polymers, with little interaction detected for caffeine. PVP was found to exhibit greater interaction and miscibility with paracetamol than did PVPVA. It was noted that lower processing temperatures (circa 40°C below the Tg of the polymer alone and Tm of the crystalline drug) and higher drug loadings with associated molecular dispersion up to 50% w/w were possible for the paracetamol dispersions, although molecular dispersion with the non-interactive caffeine was noted at loadings up to 20% w./w. A lower processing temperature was also noted for caffeine-loaded systems despite the absence of detectable interactions. The study has therefore indicated that theoretical and experimental detection of miscibility and drug-polymer interactions may lead to insights into product processing and extrudate structure, with direct molecular interaction representing a helpful but not essential aspect of drug-polymer combination prediction.

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Section: Interaction Assessment Using Atr-ftirsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

An investigation into the influence of drug–polymer interactions on the miscibility, processability and structure of polyvinylpyrrolidone-based hot melt extrusion formulations

Chan

Craig³

2015

International Journal of Pharmaceutics

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“…Oromucosal formulations are, due to their simple use and non-invasive application, widely accepted by patients (Lam et al, 2014). They are especially suitable for pediatric (Lam et al, 2014;Sattar et al, 2014) and geriatric patients (Illangakoon et al, 2014;Sattar et al, 2014), as well as for any other patient with swallowing or digestion difficulties (Illangakoon et al, 2014). The buccal and sublingual dosage forms are among the most commonly used oromucosal delivery systems (Lam et al, 2014;Patel et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

Potrč

Baumgartner

Roškar

et al. 2015

European Journal of Pharmaceutical Sciences

146

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“…Illangakoon et al used polyvinylpyrrolidone (PVP), a hydrophilic polymer, to load paracetamol and caffeine, a pain reliever and stimulant for oral delivery. Using a high-speed camera, they found that their fibers quickly dissolved (<0.5 s) in 15 ml of saliva stimulant and caused rapid drug release [47]. For populations with difficulties swallowing medication, Noolkar et al, developed quick dissolving PVP fibers that deliver the nonsteroidal anti-inflammatory (NSAID) compound meloxicam.…”

Section: Case Studies Of Drug-eluting Fibers For Implants and Injectablesmentioning

confidence: 99%

In Pursuit of Functional Electrospun Materials for Clinical Applications in Humans

et al. 2016

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Electrospinning is a simple, low-cost and versatile approach to fabricate multifunctional materials useful in drug delivery and tissue engineering applications. Despite its emergence into other manufacturing sectors, electrospinning has not yet made a transformative impact in the clinic with a pharmaceutical product for use in humans. Why is this the current state of electrospun materials in biomedicine? Is it because electrospun materials are not yet capable of overcoming the biological safety and efficacy challenges needed in pharmaceutical products? Or, is it that technological advances in the electrospinning process are needed? This review investigates the current state of electrospun materials in medicine to identify both scientific and technological gaps that may limit clinical translation.

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Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning

Cited by 148 publications

References 50 publications

An investigation into the influence of drug–polymer interactions on the miscibility, processability and structure of polyvinylpyrrolidone-based hot melt extrusion formulations

An investigation into the influence of drug–polymer interactions on the miscibility, processability and structure of polyvinylpyrrolidone-based hot melt extrusion formulations

Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs

In Pursuit of Functional Electrospun Materials for Clinical Applications in Humans

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