2018
DOI: 10.3390/pharmaceutics10030115
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Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial Process

Abstract: Enhancing the dissolution of insoluble active ingredients comprises one of the most important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid dispersion (3rd SD) of ferulic acid was designed and fabricated by a modified coaxial electrospinning process. A traditional second generation SD (2nd SD) was also prepared by common one-fluid blending electrospinning and was used as a control. With poly(vinyl alcohol) as the fiber matrix and polyvinylpyrrolidone K10 as an additive in … Show more

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Cited by 30 publications
(17 citation statements)
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References 47 publications
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“…However, when R value is beyond the limitation, i.e., the sheath solvent flow rate is too large, the beads-on-a-string or spindles-on-a-string may be generated. This is because the sheath solvent can't be completely exhausted in time and in turn influence the solidification of the core fluid [42].…”
Section: The Nanostructures Created By the Modified Coaxial Electrospmentioning
confidence: 99%
“…However, when R value is beyond the limitation, i.e., the sheath solvent flow rate is too large, the beads-on-a-string or spindles-on-a-string may be generated. This is because the sheath solvent can't be completely exhausted in time and in turn influence the solidification of the core fluid [42].…”
Section: The Nanostructures Created By the Modified Coaxial Electrospmentioning
confidence: 99%
“…2). Due to the smaller diameter, high surface area, huge porosity and the typical 3-D web inner structure nanofibers have shown the great potential application in drug delivery [15][16][17][18].…”
Section: Shown Inmentioning
confidence: 99%
“…As the volume of semi-solid substance increase, the spinneret is apt to be clogged and the working process is stopped. Thus, a modified coaxial electrospinning can be explored [6][7][8][9][10][11][12], in which pure solvent can be utilized as the sheath fluid to lubricate the spinning of core solution [13][14][15]. Thus, the knowledge about the raw material zein (from crops) can broaden the college students' ken about their environmental engineering's extension.…”
Section: The Role Of Mse Knowledge For Cultivating Ee Undergraduatmentioning
confidence: 99%