Fast determination of diphenhydramine, pyridoxine, and 8-chlorotheophylline by capillary electrophoresis with capacitively coupled contactless conductivity detection

Ribeiro, Michelle M. A. C.; Freitas, Jhonys Machado; Muñoz, Rodrigo A.A.; Lago, Claudimir Lúcio do; Richter, Eduardo M.

doi:10.1039/c6ay00943c

Cited by 17 publications

(11 citation statements)

References 33 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A CE‐C 4 D method for simultaneous determination of diphenhydramine, pyridoxine and 8‐chlorotheophylline in pharmaceutical sample was described (Ribeiro, Freitas, Muñoz, Do Lago, & Richter, ). The separation of the three compounds was achieved in a BGE consisting of boric acid 20 mmol L −1 and sodium hydroxide at pH 9.0.…”

Section: Pharmaceutical Analysismentioning

confidence: 99%

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Elbashir

Schmitz

Aboul‐Enein

2017

Biomedical Chromatography

View full text Add to dashboard Cite

Capacitively coupled contactless conductivity detection (C D) has appeared as a powerful technique for the detection of compounds lacking chromogenic or fluorogenic group. Since our last review (Biomedical Chromatography 2014; 28: 1502-1506) several new capillary electrophoresis (CE)-C D methods have been reported. This review provides an update of the most recent utilization of CE-C D in the field of pharmaceutical, biomedical and food analysis covering the period from February 2014 to October 2016. The use of CE with C D in the pharmaceutical field has been shown in many papers. Examples illustrate the applicability of CE-C D in the fields of pharmaceutical, biomedical and food analysis. Finally, general conclusions and perspectives are provided.

show abstract

Section: Pharmaceutical Analysismentioning

confidence: 99%

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Elbashir

Schmitz

Aboul‐Enein

2017

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Methods for determination of NH 4 + are mainly based on spectrophotometry [6][7][8], fluorometry [9], chemiluminescence [10,11], conductometry [12,13], potentiometry [14,15], and amperometry [16][17][18][19]. DIP is predominantly determined by LC [20][21][22][23][24], the most commonly employed technique for pharmaceuticals analysis, and some CE methods [25][26][27][28]. However, no analytical methods are described for simultaneous determination of these compounds.…”

Section: Introductionmentioning

confidence: 99%

Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples

Costa

Marra

Oliveira

et al. 2018

J of Separation Science

View full text Add to dashboard Cite

Ammonium and diphenhydramine are active ingredients commonly found in the same pharmaceutical preparations. We report, for the first time, a sub-minute method for the simultaneous determination of ammonium and diphenhydramine. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. Both analytes can be quantified in a single run (∼80 injections/h) using 30 mmol/L 2-(N-morpholino)ethanesulfonic acid and 15 mmol/L lithium hydroxide (pH 6.0) as background electrolyte. The separation by capillary electrophoresis was achieved on a fused-silica capillary (50 cm total length, 10 cm effective length, and 50 μm inside diameter). The limits of detection were 0.04 and 0.02 mmol/L for ammonium and diphenhydramine, respectively. The proposed method also provided adequate recovery values for spiked samples (100-106 and 97-104% for ammonium and diphenhydramine, respectively). The results obtained with the new capillary electrophoresis method were compared with those of the high-performance liquid chromatography method for diphenhydramine and the Kjeldahl method for ammonium and no statistically significant differences were found (95% confidence level).

show abstract

“…C 4 D is constituted of two cylindrical electrodes situated around the capillary column without any direct contact with the electrolyte solution. It can be easily positioned anywhere along the capillary [27][28][29]. This system often offers short analysis time combined with low-cost, high separation efficiency and low consumption of reagents and samples [30].…”

Section: Introductionmentioning

confidence: 99%

Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

Marra

Cunha

Muñoz

et al. 2017

J of Separation Science

Self Cite

View full text Add to dashboard Cite

We report a new fast method for the simultaneous determination of amoxicillin, clavulanate, and potassium by capillary electrophoresis with capacitively coupled contactless conductivity detection. Samples containing potassium as the cation, and both amoxicillin and clavulanate as anions were determined simultaneously in a single run (in less than 45 s) using 10 mmol/L of both 2-amino-2-hydroxymethyl-propane-1,3-diol and 3-{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]amino}-1-propanesulfonic acid (pH 8.4) as the background electrolyte. Limits of detection were 25.0, 5.0, and 4.0 μmol/L for amoxicillin, clavulanate, and potassium, respectively. The proposed method is inexpensive, simple, fast (75 injections h ), environment friendly (minimal waste generation), and accurate (recovery values between 98 and 103%). The results obtained with the proposed method were statistically similar (95% confidence level) to those obtained by using high-performance liquid chromatography (amoxicillin and clavulanate) and flame photometry (potassium).

show abstract

Fast determination of diphenhydramine, pyridoxine, and 8-chlorotheophylline by capillary electrophoresis with capacitively coupled contactless conductivity detection

Abstract: This work reports a new and fast method for the simultaneous determination of diphenhydramine, pyridoxine, and 8-chlorotheophylline by CE-C4D.

Cited by 17 publications

References 33 publications

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples

Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

Contact Info

Product

Resources

About

Fast determination of diphenhydramine, pyridoxine, and 8-chlorotheophylline by capillary electrophoresis with capacitively coupled contactless conductivity detection

Abstract: This work reports a new and fast method for the simultaneous determination of diphenhydramine, pyridoxine, and 8-chlorotheophylline by CE-C4D.

Cited by 17 publications

References 33 publications

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D): An update

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C4D): An update

Ultrafast capillary electrophoresis method for the simultaneous determination of ammonium and diphenhydramine in pharmaceutical samples

Single‐run capillary electrophoresis method for the fast simultaneous determination of amoxicillin, clavulanate, and potassium

Contact Info

Product

Resources

About

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update

Application of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE‐C⁴D): An update