Fast determination of 14 mycotoxins in chestnut by dispersive solid‐phase extraction coupled with ultra high performance liquid chromatography‐tandem mass spectrometry

Liang, Jingyun; Dong, Yiyang; Yuan, Xiaocong; Fan, Lijun; Zhao, Shancang; Wang, Lei

doi:10.1002/jssc.201900050

Cited by 22 publications

(17 citation statements)

References 29 publications

(35 reference statements)

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“…Four milliliters (10 μg/mL) AFB1 solution (prepared in methanol-water) was added into the tubes. The mixture was vigorously shaken at 2500 rpm for a series of time (1,2,3,6,9,12,15,20,25,30,35,40, and 60 min). The tubes were centrifuged and the supernatants were measured by HPLC.…”

Section: Dynamics Of Polymersmentioning

confidence: 99%

“…As one of the most abundant and powerful natural chemical carcinogen, aflatoxins (AFs) have been found to be carcinogenic, teratogenic, and mutagenic to humans. Serious health problems and economic losses caused by this category have become a global issue . Therefore, it is urgent to develop reliable analytical technique for solving mycotoxin problems in various samples employed.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is urgent to develop reliable analytical technique for solving mycotoxin problems in various samples employed. Recently, some promising techniques for analysis of AFs, for instance, TLC, LC associated with UV, fluorescence or MS detection, GC and enzyme‐linked immunosorbent assay have been reported .…”

Section: Introductionmentioning

confidence: 99%

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Combined biocompatible medium with molecularly imprinted polymers for determination of aflatoxins B1 in real sample

Song

Chen

et al. 2019

J of Separation Science

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A kind of molecularly imprinted polymers modified with biocompatible medium was prepared by suspension polymerization. The obtained hybrid materials were used as the adsorbents for the solid‐phase extraction of aflatoxins B1 in real samples. A structural analog of the target, 6‐methyl‐4‐phenylchroman‐2‐one was used as the pseudo‐template, owing to their lower toxicity and cheaper price compared with aflatoxins B1; and methacrylic acid and glycidyl methacrylate were used as the co‐monomers. Scanning electron microscopy and size distribution analysis were used to characterize the obtained polymers. The extraction parameters were optimized to achieve the desired extraction performance. The polymer solid‐phase extraction coupled with high‐performance liquid chromatography was successfully applied to determine aflatoxins B1 from soy sauce without the process of protein removal. Under the optimum extraction conditions, the detection results of aflatoxins B1 in lab‐made column in soy sauce samples was carried out, with a recovery rate of 96%. The established method presented a linear range from 10 to 1000 ng/mL with the coefficient of determination of 0.9994 and the limit of detection of 0.05 ng/mL. Likewise, the inherent selectivity of lab‐made column towards aflatoxins B1, Ochratoxin A, and Zearalenone was demonstrated.

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Section: Dynamics Of Polymersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined biocompatible medium with molecularly imprinted polymers for determination of aflatoxins B1 in real sample

Song

Chen

et al. 2019

J of Separation Science

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“…LC‐MS/MS has been reported and considered as the universal approach for mycotoxin screening due to their high selectivity for analyzing several analyte in one run [17–22]. Recently, a few multi‐mycotoxin analysis methods have been described in varied food commodities, however the validated methods for baby food analysis are rare as high sensitivity is required to satisfy the strict regulation in such types of matrices [7,23].…”

Section: Introductionmentioning

confidence: 99%

Fast and efficient immunoaffinity column cleanup and liquid chromatography–tandem mass spectrometry method for the quantitative analysis of aflatoxins in baby food and feeds

AlFaris

Wabaidur

ALOthman

et al. 2020

J of Separation Science

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An ultra high performance liquid chromatography-tandem mass spectrometric method has been developed for the highly sensitive and selective determination of regulated aflatoxins. The extraction of aflatoxins from baby food matrices were performed using liquid-liquid extraction procedure followed by immunoaffinity column cleanup. The higher sensitivity for the determination of target aflatoxins was fulfilled by applying a preconcentration step with immunoaffinity columns after acetonitrilewater extraction. The enhanced selectivity was attained with the triple quadrupole mass analyzer operated in electrospray positive ionization mode. Method validation was tested in five different baby food matrices by recovery experiments. Satisfactory recoveries, between 92 and 103%, with relative standard deviations lower than 8% were achieved in all the tested matrices. The proposed method was found to be specific as no interference peaks were observed for blank samples. The limit of detection of the method was found to be in the range of 0.003-0.008 ng/mL. The validated method was fruitfully applied to the screening of aflatoxins in baby foods and feeds sample retailed in local markets of Riyadh, Saudi Arabia. The obtained levels of all analyzed aflatoxins were below the regulation limits set by European Agency.

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“…PA was previously detected in many agricultural products, including animal feed, corns, wheat, nuts, spices and fruits 3,8–13 . Liang et al .…”

Section: Introductionmentioning

confidence: 99%

Penicillic acid in fruits: method development, validation by liquid chromatography–tandem mass spectrometry and survey in southern China

Guan

You

et al. 2020

J Sci Food Agric

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BACKGROUND Penicillic acid (PA) is produced by Aspergillus spp. and Penicillium spp., which are common postharvest and storage fungi of fruits. PA can be of concern for human health because of its toxicity and high fruit consumption by the population. However, no data on PA occurrence in various fruits have yet been reported. A quick, easy, cheap, effective, rugged and safe (QuEChERS) approach for PA determination in various fruits was developed and applied to explore PA incidence in fruits. RESULTS The modified QuEChERS procedure with extraction by ethyl acetate and purification by multi‐walled carbon nanotubes (MWCNTs), primary secondary amine (PSA) and octadecyl silane (C18) was established to determine PA in various fruits by high‐performance liquid chromatography–tandem mass spectrometry (HPLC‐MS/MS). The average recoveries were 72.9–102.2% and relative standard deviations (RSDs) were 1.3–7.9%. A total of 161 fruits samples, including kiwi, apple, peach, grape and mandarin/orange, were collected in southern China. The incidence of PA in fruits was 14.9% and the levels of PA contamination were 0.200–0.596 μg kg−1. Our results suggested that orange/mandarin, grape and kiwi were favorable matrices for Aspergillus spp. and Penicillium spp. to produce PA, rather than peach and apple. CONCLUSION To the best of our knowledge, this is the first report about PA contamination in various fruits in China. Our study emphasizes the necessity of the current established method, which could be used for continuous monitoring of PA and reducing the health risk to Chinese consumers. © 2020 Society of Chemical Industry

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Fast determination of 14 mycotoxins in chestnut by dispersive solid‐phase extraction coupled with ultra high performance liquid chromatography‐tandem mass spectrometry

Cited by 22 publications

References 29 publications

Combined biocompatible medium with molecularly imprinted polymers for determination of aflatoxins B1 in real sample

Combined biocompatible medium with molecularly imprinted polymers for determination of aflatoxins B1 in real sample

Fast and efficient immunoaffinity column cleanup and liquid chromatography–tandem mass spectrometry method for the quantitative analysis of aflatoxins in baby food and feeds

Penicillic acid in fruits: method development, validation by liquid chromatography–tandem mass spectrometry and survey in southern China

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