Fast Customization of Microneedle Arrays by Static Optical Projection Lithography

Liu, Xuan; Chen, Huafu; Yuan, Xin; Yang, Ling; Luo, Jing; Jiang, Xuebing; Gou, Zhiyuan; Li, Bo; Jiang, Xian; Gou, Maling

doi:10.1021/acsami.1c21489

Cited by 14 publications

(16 citation statements)

References 42 publications

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“…However, the common 3D printing technology available on the market with low precision and a rough surface is far from meeting the processing requirements of the microneedle patch. As shown in Figure f, Gou and co-workers proposed a 3D-printing technology, named static optical projection lithography (SOPL), for quickly fabricating MNAs in seconds . On the basis of the spatial distribution of projected digital light, this technology enabled fast fabrication without the need for molding or multiple printing.…”

Section: Microneedle Fabrication Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

Zhou

Liao

et al. 2023

Anal. Chem.

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Section: Microneedle Fabrication Methodsmentioning

confidence: 99%

“…Reprinted from Liu, X.; Li, R.; Yuan, X.; Yang, L.; Luo, J.; Jiang, X.; Gou, Z.; Li, B.; Jiang, X.; Gou, M. Fast Customization of Microneedle Arrays by Static Optical Projection Lithography. ACS Applied Materials & Interfaces 2021 , 13 (50), 60522–60530 . Copyright 2021 American Chemical Society.…”

Section: Microneedle Fabrication Methodsmentioning

confidence: 99%

Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

Zhou

Liao

et al. 2023

Anal. Chem.

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“…Regarding hair loss treatment, some studies have shown that drug-free microneedles can remodel the perifollicular microenvironment in the balding region and then induce hair regeneration [8,9]. In addition, the specific distribution of microneedles can deliver substances to specific locations [10,11]. Based on these reports, we propose a hypothesis that the customized MNA can locally modulate the dermal microenvironment and then precisely promote the hair regeneration in situ.…”

Section: Introductionmentioning

confidence: 90%

“…3D printing can be used for the flexible customization of MNA with a fine structure and personalized shape [12,13]. Recently, our group developed a 3D printing technology, static optical projection lithography (SOPL), for flexibly customizing MNA, which can rapidly construct customized MNA within seconds through the spatial polymerization of monomer solution induced by static projected digital light [11,14]. Here, SOPL technology was used to quickly fabricate MNAs with designed shapes.…”

Section: Introductionmentioning

confidence: 99%

3D printing of microneedle arrays for hair regeneration in a controllable region

Yuan

Zhang

et al. 2023

Mol Biomed

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Hair loss is a common skin disease that causes intense emotional suffering. Hair regeneration in a personalized area is highly desirable for patients with different balding conditions. However, the existing pharmaceutical treatments have difficulty precisely regenerating hair in a desired area. Here, we show a method to precisely control the hair regeneration using customized microneedle arrays (MNAs). The MNA with a customized shape is fast fabricated by a static optical projection lithography process in seconds, which is a 3D printing technology developed by our group. In the mouse model, MNA treatment could induce hair regrowth in a defined area corresponding to the customized shape of MNA. And the regenerated hair promoted by MNAs had improved quality. Cellular and molecular analysis indicated that MNA treatment could recruit macrophages in situ and then initiate the proliferation of hair follicle stem cells, thereby improving hair regeneration. Meanwhile, the activation of the Wnt/β-catenin signaling pathway was observed in hair follicles. The expressions of Hgf, Igf 1 and Tnf-α were also upregulated in the treated skin, which may also be beneficial for the MNA-induced hair regeneration. This study provides a strategy to precisely control hair regeneration using customized microneedle arrays by recruiting macrophages in situ, which holds the promise for the personalized treatment of hair loss.

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“…Together, it remains a challenge to rapidly fabricate high-quality HMNs. Nonetheless, our group developed a 3D printing technology, namely static optical projection lithography (SOPL), for rapid customizing high-quality solid microneedle arrays[ 22 ]. The obtained solid microneedles do not have the stair-like surface and layer-by-layer structure that are associated with the common 3D-printing technologies.…”

Section: Introductionmentioning

confidence: 99%

Fast Customization of Hollow Microneedle Patches for Insulin Delivery

Li¹,

Li²,

Yuan³

et al. 2022

IJB

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Hollow microneedle patches (HMNPs) have great promise for efficient and precise transdermal drug delivery in a painless manner. Currently, the clinical application of HMNPs is restricted by its complex manufacturing processes. Here, we use a new three-dimensional (3D) printing technology, static optical projection lithography (SOPL), for the fast fabrication of HMNPs. In this technology, a light beam is modulated into a customized pattern by a digital micromirror device (DMD) and projected to induce the spatial polymerization of monomer solutions which is controlled by the distribution of the light intensity in the monomer solutions. After an annulus picture is inputted into the DMD via the computer, the microneedles with hollow-cone structure can be precisely printed in seconds. By designing the printing pictures, the personalized HMNPs can be fast customized, which can afford the scale-up preparation of personalized HMNPs. Meanwhile, the obtained hollow microneedles (HMNs) have smooth surface without layer-by-layer structure in the commonly 3D-printed products. After being equipped with a micro-syringe, the HMNPs can efficiently deliver insulin into the skin by injection, resulting in effective control of the blood glucose level in diabetic mice. This work demonstrates a SOPL-based 3D printing technology for fast customization of HMNPs with promising medical applications.

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Fast Customization of Microneedle Arrays by Static Optical Projection Lithography

Cited by 14 publications

References 42 publications

Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

Bridging the Gap between Invasive and Noninvasive Medical Care: Emerging Microneedle Approaches

3D printing of microneedle arrays for hair regeneration in a controllable region

Fast Customization of Hollow Microneedle Patches for Insulin Delivery

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