Fast chromatographic separation techniques as competitors to chemical and biochemical sensor systems

Cammann, Karl; Kleiböhmer, Wolfgang; Mussenbrock, Elmar; Roß, Bernhard; Zuther, Frank

doi:10.1007/bf00326596

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…1 Chromatographic methods are commonly used when the sample contains a mixture of surfactants that need to be individually quantified. 2,3 In situations where a single surfactant is present in a given sample or the total surfactant concentration is relevant, nonspecific titration methods can be used. 4,5 Titrations such as the Wickbold potentiometric procedure for nonionic surfactants 6,7 and the colorimetric methylene blue method for anionic surfactants 8 generally involve preconcentration and extraction steps to improve detectability and minimize interferences.…”

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“…Specific and nonspecific analytical methods have been developed for the determination of surfactants both in cosmetics, paints, household soaps and detergents, and pharmaceutical formulations and in wastewater management , In situations where a single surfactant is present in a given sample or the total surfactant concentration is relevant, nonspecific titration methods can be used. , Titrations such as the Wickbold potentiometric procedure for nonionic surfactants , and the colorimetric methylene blue method for anionic surfactants generally involve preconcentration and extraction steps to improve detectability and minimize interferences. As a result, existing schemes are not ideal, and a simple sensor for the quantification of surfactants would help to alleviate many of the aforementioned problems.…”

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Biosensor for the Nonspecific Determination of Ionic Surfactants

Lundgren

Bright

1996

Anal. Chem.

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We report the analytical figures of merit for the first biosensor for ionic surfactant quantification. The biosensor consists of a silanized silica optical fiber, onto which acrylodan-labeled bovine serum albumin (BSA-Ac) is immobilized. Recent work from our laboratory on native BSA-Ac (Lundgren, J. S.; Bright, F. V. J. Phys. Chem. 1996, 100, 8580-8586) has shown that ionic surfactants dehydrate the local environment surrounding the lone acrylodan residue, open up the pocket hosting the acrylodan reporter group, and dramatically increase the segmental mobility of domain I in BSA. In the current work, we use BSA-Ac as an actual biorecognition element for surfactant detection and quantification. We also compare several BSA-Ac immobilization strategies and determine the analytical figures of merit for the BSA-Ac-based biosensor to a prototypical analyte, cetyltrimethylammonium bromide (CTAB). The biosensor linear dynamic range extends from 5 to 60 μM, and the t(90) response time (90% of the total response) is less than 30 s. Biosensor response precision (relative standard deviation) during 34 sensing cycles is 2.5%. On the down side, biosensor performance decreases 38% after 25 days of storage; however, this drift can be compensated. This work also demonstrates the utility of BSA-Ac as a model biorecognition element-reporter group system for grading the suitability of different surface immobilization strategies.

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Biosensor for the Nonspecific Determination of Ionic Surfactants

Lundgren

Bright

1996

Anal. Chem.

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“…Research in the area of sensor development for metal ion detection in chemical and biological applications has received considerable attention in recent years. [1][2][3] In particular, the application of host-guest chemistry to sensor development has proved to be a very useful detection method. 4 Many different receptors (hosts) including crown ethers, cryptands and calixarenes have been synthesized as molecular recognition agents for the binding of various metal ions (guests).…”

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confidence: 99%