Fast axonal transport of acetylcholinesterase in rat sciatic motoneurons is enhanced following prolonged daily running, but not following swimming

Jasmin, B. J.; Lavoie, P.‐A.; Gardiner, Phillip F.

doi:10.1016/0304-3940(87)90625-2

Cited by 17 publications

(14 citation statements)

References 13 publications

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“…Nevertheless, moderate exercise after disease onset can also improve ALS functional disability scores and ameliorate disease symptoms (12–14). However, rats exposed to exhaustive running show an overall reduction in fast axonal transport capability (15). On this basis, one may question that short-lasting physical exercise tends to delay disease progression in diseased animals and humans but prolonged physical exercise may hasten the metabolic requirements of motor neurons and glia.…”

Section: Discussionmentioning

confidence: 99%

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

Beghi

Logroscino

Chiò

et al. 2010

Amyotrophic Lateral Sclerosis

113

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Our objective was to investigate exposure to physical exercise and trauma in patients with amyotrophic lateral sclerosis (ALS) compared to the general population. Previous studies in this area have yielded conflicting results. Using population-based ALS registries from Italy, the UK and Ireland, newly diagnosed patients with definite, probable or possible ALS were enrolled in a case-control study with two age- and sex-matched controls for each patient. Source, intensity and duration of physical activity and history of trauma were recorded. We here present the results of a pilot investigation. We studied 61 patients and 112 controls. Forty-one per cent of cases and 17.0% of controls (p = 0.001) had blue-collar occupations; 13.1% versus 3.6% reported strenuous physical activity at work (p = 0.05). Compared with controls, ALS patients had a longer exposure to work-related (10.7 vs. 7.3 years; p = 0.02) and sport-related physical exercise (9.6 vs. 5.2 years; p = 0.005). Three patients (0 controls) reported professional sports (p < 0.04). Traumatic events were similar. Blue collar occupation (OR 4.27; 95% CI 1.68–10.88) and duration of sport-related physical exercise (OR 1.03; 95% CI 1.00–1.05) were independent variables in multivariate analysis. We concluded that ALS is associated with physical exercise but not with traumatic events.

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Section: Discussionmentioning

confidence: 99%

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

Beghi

Logroscino

Chiò

et al. 2010

Amyotrophic Lateral Sclerosis

113

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“…A previous study has already shown that running training does not change the AChE specific activity of the sciatic nerve trunk (Jasmin et al, 1987). However, a possible effect on the indi- Val ues are I i SD: asterisks denote statlstwally significant differences between mean\ @ 0 "5.…”

Section: Sciatic Nervementioning

confidence: 97%

Regulation by exercise of the pool of G4 acetylcholinesterase characterizing fast muscles: opposite effect of running training in antagonist muscles

Jasmin

Gisiger

1990

J. Neurosci.

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“…Increased long-term neuromuscular activity may increase the uptake of trophic substances (20), which, when limited, are known to cause cell death (29). Thus, the up-regulation of neurotrophic factors and sensitivity (receptors) of the MN via increased neuromuscular activity may explain the "localized" effect of exercise on MU survival.…”

Section: Strength Voluntary Activation and Twitch Pro-mentioning

confidence: 99%

Motor Unit Survival in Lifelong Runners Is Muscle Dependent

Power

Dalton

Behm

et al. 2012

Medicine &Amp; Science in Sports &Amp; Exercise

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Although there were no significant differences in MUNE between both older groups in the biceps brachii muscle, with the number of subjects tested here, we cannot eliminate the possibility of some whole-body neuroprotective effect. However, when compared with the remote biceps muscle, a greater influence on age-related spinal motoneuron survival was found in a chronically activated MN pool specific to the exercised muscle.

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Fast axonal transport of acetylcholinesterase in rat sciatic motoneurons is enhanced following prolonged daily running, but not following swimming

Cited by 17 publications

References 13 publications

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

Regulation by exercise of the pool of G4 acetylcholinesterase characterizing fast muscles: opposite effect of running training in antagonist muscles

Motor Unit Survival in Lifelong Runners Is Muscle Dependent

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