Fast and slow biomembrane solubilizing detergents: Insights into their mechanism of action

Lete, Marta G.; Monasterio, Bingen G.; Collado, M. Isabel; Medina, Milagros; Sot, Jesús; Alonso, Alicia; Goñi, Félix M.

doi:10.1016/j.colsurfb.2019.110430

Cited by 18 publications

(16 citation statements)

References 29 publications

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“…The structure of a lipid bilayer can be compromised through the formation of pores that perforate the membrane, due to the presence specific molecules or physical stimuli, e.g., electric field [737], ultrasound [738,739], and charge imbalance [740,741]. Finally, a lipid bilayer can be dissolved completely at the molecular level by, e.g., detergents [742,743] or organic solvents [744].…”

Section: A Clear Case Of Drug Membrane Interaction As Mechanism Of Action-antimicrobial Agentsmentioning

confidence: 99%

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

2021

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We review the use of molecular dynamics (MD) simulation as a drug design tool in the context of the role that the lipid membrane can play in drug action, i.e., the interaction between candidate drug molecules and lipid membranes. In the standard “lock and key” paradigm, only the interaction between the drug and a specific active site of a specific protein is considered; the environment in which the drug acts is, from a biophysical perspective, far more complex than this. The possible mechanisms though which a drug can be designed to tinker with physiological processes are significantly broader than merely fitting to a single active site of a single protein. In this paper, we focus on the role of the lipid membrane, arguably the most important element outside the proteins themselves, as a case study. We discuss work that has been carried out, using MD simulation, concerning the transfection of drugs through membranes that act as biological barriers in the path of the drugs, the behavior of drug molecules within membranes, how their collective behavior can affect the structure and properties of the membrane and, finally, the role lipid membranes, to which the vast majority of drug target proteins are associated, can play in mediating the interaction between drug and target protein. This review paper is the second in a two-part series covering MD simulation as a tool in pharmaceutical research; both are designed as pedagogical review papers aimed at both pharmaceutical scientists interested in exploring how the tool of MD simulation can be applied to their research and computational scientists interested in exploring the possibility of a pharmaceutical context for their research.

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Section: A Clear Case Of Drug Membrane Interaction As Mechanism Of Action-antimicrobial Agentsmentioning

confidence: 99%

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

2021

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“…This process may be hindered by the presence of cholesterol in the cell membrane ( Riske et al, 2017 ). The cell wall composition may also influence the rate at which the process of lipid disruption occurs ( Lete et al, 2019 ). In the case of Gram-positive bacteria, there is no outer membrane.…”

Section: Synergistic Role Of Soap Ingredients In Removal And/or Inactivation Of Pathogensmentioning

confidence: 99%

Soap, water, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an ancient handwashing strategy for preventing dissemination of a novel virus

Ijaz

Nims

Szalay

et al. 2021

PeerJ

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Public Health Agencies worldwide (World Health Organization, United States Centers for Disease Prevention & Control, Chinese Center for Disease Control and Prevention, European Centre for Disease Prevention and Control, etc.) are recommending hand washing with soap and water for preventing the dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. In this review, we have discussed the mechanisms of decontamination by soap and water (involving both removal and inactivation), described the contribution of the various components of formulated soaps to performance as cleansers and to pathogen inactivation, explained why adherence to recommended contact times is critical, evaluated the possible contribution of water temperature to inactivation, discussed the advantages of antimicrobial soaps vs. basic soaps, discussed the differences between use of soap and water vs. alcohol-based hand sanitizers for hand decontamination, and evaluated the limitations and advantages of different methods of drying hands following washing. While the paper emphasizes data applicable to SARS-CoV-2, the topics discussed are germane to most emerging and re-emerging enveloped and non-enveloped viruses and many other pathogen types.

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“…Los datos de esta tabla se han recopilado principalmente de publicaciones en las que se han comparado varios detergentes en las mismas condiciones. Se pueden ver más ejemplos en [150]. .…”

Section: 9b El Mecanismo De Saturación De La Bicapa Para Una Solubilización Relativamente Rápidaunclassified

“…Más recientemente, Lete y cols. [150] hicieron un gran esfuerzo para entender la distinción entre detergentes que actúan lenta o rápidamente según su cabeza polar, o su capacidad de volteo de una monocapa a la otra (flip-flop) (ver 2.9.d y 4.2). Evaluaron la solubilización de vesículas lipídicas de fosfatidilcolina de huevo por veintiún detergentes estructuralmente heterogéneos disponibles comercialmente, mediante la disminución de la turbidez de la suspensión de vesículas, ampliando así notablemente los resultados expuestos en la Tabla 1.…”

Section: 4c Solubilización De Bicapas Lipídicas Por Detergentesunclassified

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2021

an.ranf

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Publicación trimestral (4 números al año) © 2020. Anales RANF Reservados todos los derechos. El contenido de la presente publicación no puede ser reproducido, ni transmitido por ningún procedimiento electrónico o mecánico, incluyendo fotocopia, grabación magnética, ni registrado por ningún sistema de recuperación de información, en ninguna forma, ni por ningún medio, sin la previa autorización por escrito del titular de los derechos de explotación de la misma. Anales RANF, a los efectos previstos en el artículo 32.1 párrafo segundo del vigente TRLPI, se opone de forma expresa al uso parcial o total de las páginas de Anales RANF con el propósito de elaborar resúmenes de prensa con fines comerciales. Cualquier forma de reproducción, distribución, comunicación pública o transformación de esta obra sólo puede ser realizada con la autorización de sus titulares, salvo excepción prevista por la ley.

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Fast and slow biomembrane solubilizing detergents: Insights into their mechanism of action

Cited by 18 publications

References 29 publications

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

Mechanistic Understanding from Molecular Dynamics in Pharmaceutical Research 2: Lipid Membrane in Drug Design

Soap, water, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): an ancient handwashing strategy for preventing dissemination of a novel virus

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