Fast and inexpensive method for the fabrication of transparent pressure-resistant microfluidic chips

Martin, Alexandre; Teychené, Sébastien; Camy, Séverine; Aubin, Joëlle

doi:10.1007/s10404-016-1757-7

Cited by 23 publications

(11 citation statements)

References 34 publications

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“…Moreover, when exposed to some fluids, PDMS microfluidic can swell, which impacts in device function [105][106][107]. Other microfluidic device polymers, such as thermoset polyester, polyurethane methacrylate and Norland Adhesive 81, also undergo structural changes when exposed to pressures above 10, 8 and 5 bar, respectively [108]. [115]…”

Section: Microfluidic Devicesmentioning

confidence: 99%

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

et al. 2020

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Most cancer biologists still rely on conventional two-dimensional (2D) monolayer culture techniques to test in vitro anti-tumor drugs prior to in vivo testing. However, the vast majority of promising preclinical drugs have no or weak efficacy in real patients with tumors, thereby delaying the discovery of successful therapeutics. This is because 2D culture lacks cell–cell contacts and natural tumor microenvironment, important in tumor signaling and drug response, thereby resulting in a reduced malignant phenotype compared to the real tumor. In this sense, three-dimensional (3D) cultures of cancer cells that better recapitulate in vivo cell environments emerged as scientifically accurate and low cost cancer models for preclinical screening and testing of new drug candidates before moving to expensive and time-consuming animal models. Here, we provide a comprehensive overview of 3D tumor systems and highlight the strategies for spheroid construction and evaluation tools of targeted therapies, focusing on their applicability in cancer research. Examples of the applicability of 3D culture for the evaluation of the therapeutic efficacy of nanomedicines are discussed.

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Section: Microfluidic Devicesmentioning

confidence: 99%

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

et al. 2020

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“…Until now, OSTE+ was used in combination with different window materials. Although OSTE+ devices have already been described, no microfluidic device for in-situ SAXS has been made from OSTE+ alone [27,[29][30][31][32][33][34] .…”

Section: Introductionmentioning

confidence: 99%

OSTE+ for in situ SAXS analysis with droplet microfluidic devices

et al. 2020

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“…Microfluidic devices made with capillary tubes are also inexpensive compared with conventional high pressure cells. Several types of microfluidic sys tems for high pressure applications have been developed (Marre et al, 2010), including those using micro capillary tubes (Macedo Portela da Silva et al, 2014) and polymers (Martin et al, 2016), both of which are fast and inexpensive to make.…”

Section: Introductionmentioning

confidence: 99%

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

Deleau

Fechter

Letourneau

et al. 2020

Chemical Engineering Science

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Mass transfer of COi into a H20 rich phase at high pressure in a capillary is studied • A rnethod for the determination of volumetric mass transfer coef ficient is presented.• A thermodynami c model and Raman spectroscopy are cou pied to obtain C(h con centrations.• The influen ce of flow rates on the volumetric mass transfer coefficient is studied.• The mass transfer coefficient varies along the length of the micro capillary tube.

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Fast and inexpensive method for the fabrication of transparent pressure-resistant microfluidic chips

Abstract: OATAO is an open access repository that collects the work of some Toulouse researchers and makes it freely available over the web where possible.

Cited by 23 publications

References 34 publications

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

OSTE+ for in situ SAXS analysis with droplet microfluidic devices

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

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