Fasciola hepatica: A comparative survey of adult fluke resistance to triclabendazole, nitroxynil and closantel on selected upland and lowland sheep farms in Northern Ireland using faecal egg counting, coproantigen ELISA testing and fluke histology

Hanna, R.E.B.; McMahon, Connor; Ellison, S.E.; Edgar, H.W.J.; Kajugu, P.-E.; Gordon, Alan; Irwin, D.; Barley, J.P.; Malone, F.E.; Brennan, Gerard; Fairweather, Ian

doi:10.1016/j.vetpar.2014.11.016

Cited by 71 publications

(43 citation statements)

References 32 publications

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“…Resistance to triclabendazole has been reported widely throughout the UK (Daniel et al, 2012, Gordon et al, 2012, Hanna et al, 2015). Investigation of triclabendazole resistance in fluke in laboratories worldwide has resulted in the pursuit of a number of potential candidate genes and biological pathways (reviewed by Kelley et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance

Beesley

Williams

Paterson

et al. 2017

International Journal for Parasitology

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Section: Discussionmentioning

confidence: 99%

Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance

Beesley

Williams

Paterson

et al. 2017

International Journal for Parasitology

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“…Since the first report of TCBZ resistance (in Australia, by Overend and Bowen, 1995), further well-documented reports have identified resistance in Australia (Walker et al, 2004;Brockwell et al, 2014), in South America (Olaechea et al, 2011;Ortiz et al, 2013) and in a number of European countries, including The Netherlands, UK and Ireland (e.g. Coles et al, 2000;Gaasenbeek et al, 2001;Flanagan, 2010;Mooney et al, 2009;Gordon et al, 2012;Hanna et al, 2015). Taken on its own, the existence of TCBZ resistance in diverse areas of the World is a matter of considerable concern and represents a challenge to management strategies in the future.…”

Section: Introductionmentioning

confidence: 99%

A comparative study on the impact of two artemisinin derivatives, artemether and artesunate, on the female reproductive system of Fasciola hepatica

O'Neill

Johnston

Halferty

et al. 2015

Veterinary Parasitology

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“…A three-week period allows the removal of adult F. hepatica exposed to the treatment and the release of eggs concentrated in the gall bladder (Brockwell et al 2014). Detection of F. hepatica-coproantigens has also been evaluated in AR studies (Hanna et al 2015, Novobilsky et al 2016 and may provide an interesting alternative to FEC, particularly to detect immature stages of F. hepatica (Beesley et al 2017).…”

Section: In Vivo Diagnostic Methodsmentioning

confidence: 99%

Drug resistance in parasitic helminths of veterinary importance in Chile: Status review and research needs

Pena-Espinoza

2018

Austral j. vet. sci.

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The increasing development of anthelmintic resistance (AR) in parasites of livestock is threatening animal health and production worldwide. In Chile, studies evaluating the field efficacy of anthelmintics and the detection of AR have been performed since the 2000s, but until now, no previous attempt has tried to systematise the available information. This article reviews general concepts about AR in helminths of veterinary importance, methods for diagnosis of AR and summarises the published reports of AR in Chile. Anthelmintic resistance in Chile has been reported in gastrointestinal nematodes of horses (benzimidazole resistance) and ruminants (sheep and cattle, macrocyclic lactone and benzimidazole resistance). However, these cases involved a limited number of selected farms and no further conclusions can be made of the status of parasite drug resistance at a regional or national level. No published cases of AR in Fasciola hepatica have been reported in Chilean livestock, but human infections with triclabendazole-resistant F. hepatica have been described in patients with previous consumption of watercress or untreated water from marshes grazed by livestock. Given the zoonotic potential and endemic nature of F. hepatica in Chile, it is urgent to determine the extent of liver fluke resistance. Current research gaps of the situation of AR in Chile and suggestions for the performance of laboratory and field studies are further discussed.

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Fasciola hepatica: A comparative survey of adult fluke resistance to triclabendazole, nitroxynil and closantel on selected upland and lowland sheep farms in Northern Ireland using faecal egg counting, coproantigen ELISA testing and fluke histology

Cited by 71 publications

References 32 publications

Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance

Fasciola hepatica demonstrates high levels of genetic diversity, a lack of population structure and high gene flow: possible implications for drug resistance

A comparative study on the impact of two artemisinin derivatives, artemether and artesunate, on the female reproductive system of Fasciola hepatica

Drug resistance in parasitic helminths of veterinary importance in Chile: Status review and research needs

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