Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats

Chagas, Carlos; Vieira, Antônio Wilson; Ong, Thomas Prates; Moreno, Fernando Salvador

doi:10.1590/s0102-86502009000500007

Cited by 10 publications

(6 citation statements)

References 26 publications

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“…Moreover, tumor progression is associated with increased Proliferating cell nuclear antigen (PCNA) and it was agreement with the present study 41 . In the present study, Farnesol treatment reduces PCNA expression and control the uncontrolled hepatic proliferation through its regulation in cell cycle, which correlated with the previous study 42 . Increased oxidative stress is associated with activation of inflammatory mediators, which promotes persistence inflammation.…”

Section: Discussionsupporting

confidence: 93%

“…41 In the present study, Farnesol treatment reduces PCNA expression and control the uncontrolled hepatic proliferation through its regulation in cell cycle, which correlated with the previous study. 42 Increased oxidative stress is associated with activation of inflammatory mediators, which promotes persistence inflammation. Chronic hepatic cellular inflammation is associated with epithelial cell damage and activates protumorigenic cytokines by evading immune surveillance, which initiates and promotes hepatic tumor.…”

Section: Effect Of Farnesol On Inflammatory Cytokinesmentioning

confidence: 99%

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Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma

Balaraman

Jagan

Mari

et al. 2021

Environmental Toxicology

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Hepatocellular carcinoma is a well‐known internal malignancy with increased worldwide mortality. The increased progression rate is closely associated with chronic liver diseases such as cirrhosis. Chemical carcinogens cause tumor advocacy over free radical metabolites to causes numerous biochemical and molecular changes that bring oxidative stress. In addition, inflammatory cells and its growth factor promotes the progression of liver cancer through deregulates the numerous cellular signaling pathways involved in normal cellular proliferation. Plant derived phytochemicals have a better complimentary potency to defend against a wide array of free radical mediated diseases such as cancer. More recently, we have evaluated the anticancer effect of Farnesol against DEN induced hepatocellular carcinoma in male wistar albino rats. However, the possible mechanism in which Farnesol attributes its anticancer effect against DEN induced liver cancer remains unknown. Hence in the present study, an attempt has been made to reduce the oxidative stress by appraise the antioxidant effect by Farnesol in DEN induced hepatocellular carcinoma. Elevated oxidative stress markers with concomitant decreased cellular antioxidants levels were observed in DEN induced hepatic tissues. Further, proliferating nuclei with increased proliferating cell nucleolar antigen (PCNA) and inflammatory mediator expression were observed in DEN induced rats. Oral supplementation of Farnesol to DEN induced rats significantly decrease the oxidative stress markers and increase the cellular antioxidant status. Moreover, Farnesol treatment decreases the argyrophilic nuclear organizer region and PCNA along with decreased expression of inflammatory mediators suggest that Farnesol treatment restores DEN induced hepatic abnormalities and protects liver from cancer progression.

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Section: Discussionsupporting

confidence: 93%

Section: Effect Of Farnesol On Inflammatory Cytokinesmentioning

confidence: 99%

Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma

Balaraman

Jagan

Mari

et al. 2021

Environmental Toxicology

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“…Farnesol is a 15-carbon isoprenoid found in a variety of plant products, such as orange peel, lemon-grass oil, strawberries and chamomile (25)(26)(27). Farnesol has been shown to have anti-bacterial (28,29), anticancer (16,21,30,31) and olfactory nerve effects (32).…”

Section: Introductionmentioning

confidence: 99%

Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathways

Park

Kwon

Kim

et al. 2014

International Journal of Molecular Medicine

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The aim of this study was to investigate the effect of farnesol on the induction of apoptosis in DU145 prostate cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay showed that cell proliferation decreased significantly in a dose- and time-dependent manner. 4',6-Diamidino-2-phenylindole staining showed that chromatin condensation in cells treated with 60 µM of farnesol was markedly higher than in the control groups. Farnesol increased the expression of p53, p-c-Jun N-terminal kinase, cleaved-caspase-3, Bax, and cleaved-caspase-9, but decreased the expression of p-phosphatidylinositol-3-kinase (PI3K), p-Akt, p-p38, Bcl-2, and p-extracellular signal-regulated protein kinase, in a dose-dependent manner. The apoptotic cell ratio increased in a dose-dependent manner. The tumor growth inhibitory effect of farnesol was investigated in a mouse model. Compared to the control group, tumor volume decreased significantly in the group administered 50 mg/kg farnesol. Apoptosis was frequently detected in this same group by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. The results indicated that farnesol induced apoptosis of DU145 prostate cancer cells through the PI3K/Akt and mitogen-activated protein kinase signaling pathways.

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“…According to the literature, the pharmacological effects of farnesol include its antimicrobial activity against the following pathogens: Streptococcus aureus, Streptococcus mutants, Pseudomonas , and Staphylococcus epidermidis [15–19]. In addition to the anti‐cell proliferation [20] and anti‐inflammatory properties [21] of farnesol, its antifungal effect has also been determined by its inhibition of the growth and dimorphism of strains of Paracoccidioides brasiliensis [22] and Candida albicans [23,24]. In the present study, the antinociceptive activity of farnesol () was evaluated using the acetic acid–induced writhing test and the formalin test.…”

Section: Introductionmentioning

confidence: 99%

Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice

Júnior

Benedito

Pereira

et al. 2012

Fundamemntal Clinical Pharma

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Farnesol, a sesquiterpene alcohol, has been shown to have antioxidant and anti-inflammatory properties. Recent studies have found that antioxidant compounds may exert a certain protective effect against neurotoxicity. The objective of this study was to evaluate the antinociceptive activity of farnesol (FAR) and its neurotoxic effects on the brains of adult mice. In this study, two mouse models of analgesia were used to evaluate FAR at doses of 50, 100, and 200 mg/kg, injected intraperitoneally (i.p.). In the acetic acid-induced writhing test, a significant decrease was found in the number of contortions in the FAR-treated mice at doses of 50, 100, and 200 mg/kg. FAR was also found to inhibit the licking response in the injected paw at doses of 100 and 200 mg/kg (i.p.) in the first (0-5 min) and second phases (15-30 min) of the formalin test. To evaluate neurotoxic effects, Swiss mice were treated with 0.9% saline (i.p., control group), 0.05 Tween 80 dissolved in 0.9% saline (i.p., vehicle group), and FAR 50, 100, or 200 mg/kg, i.p. Following treatment, all groups were observed for 72 h. In the FAR 200-mg group, 16% of the animals suffered brain injury that affected 12% of the area of the hippocampus. No lesions were found in the hippocampal and striatal regions of the brain in any of the animals treated with the 50 and 100 mg/kg doses of FAR. In conclusion, FAR exerts an antinociceptive effect with no significant neurotoxicity in the brains of adult mice.

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Farnesol inhibits cell proliferation and induces apoptosis after partial hepatectomy in rats

Cited by 10 publications

References 26 publications

Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma

Farnesol alleviates diethyl nitrosamine induced inflammation and protects experimental rat hepatocellular carcinoma

Farnesol induces apoptosis of DU145 prostate cancer cells through the PI3K/Akt and MAPK pathways

Farnesol: antinociceptive effect and histopathological analysis of the striatum and hippocampus of mice

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