Farbreaktion von Phenolen mit 4-Aminoantipyrin I. Untersuchung der Eigenschaften des Farbproduktes und der Reaktionsbedingungen

Svobodová, D.; Gasparič, J.

doi:10.1135/cccc19680042

Cited by 27 publications

(3 citation statements)

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“…[19] Type II methods involve the condensation of phenols with 4-aminoantipyrine in the presence of an oxidizing agent in alkaline medium to form an antipyrine dye. [20][21][22] The conditions of this reaction, such as pH, type of buffer solution and oxidant, concentration of reagent and oxidant, etc., should be strictly monitored.…”

Section: Introductionmentioning

confidence: 99%

A Sensitive Spectrophotometric Method for Determination of Diosmin Using Sodium Nitroprusside as a Chromogenic Reagent

Moldovan

Aboul‐Enein

2011

Instrumentation Science & Technology

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A simple and sensitive method for the spectrophotometric determination of diosmin has been developed, and optimum reaction conditions along with other analytical parameters have been evaluated. Diosmin, as a phenolic compound, reacts with sodium nitroprusside and hydroxylamine hydrochloride in a basic medium to give a green-colored product. At analytical wavelength of 763 nm, Beer's law is obeyed over the concentration range 2-140 lg mL À1 of diosmin with a correlation coefficient of 0.9997. The molar absorptivity is 9671 L mol À1 cm À1 . The limits of detection (LOD) and quantification (LOQ) are 0.05 and 0.2. lg mL À1 , respectively. The method has been successfully applied to the determination of diosmin in a commercial pharmaceutical preparation. The results were compared favorably with those obtained by the 4-aminoantipyrine method.

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Section: Introductionmentioning

confidence: 99%

A Sensitive Spectrophotometric Method for Determination of Diosmin Using Sodium Nitroprusside as a Chromogenic Reagent

Moldovan

Aboul‐Enein

2011

Instrumentation Science & Technology

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“…3 This reaction is the basis for many analytical procedures involving conventional spectrophotometric methods. [9][10][11][12] According to numerous scientific papers and pharmacopoeias, impurity determination in drug substances and drug products is often carried out using various instrumental techniques, such as high-performance liquid chromatography (HPLC), mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectrometry 13,14 or, more recently, so-called hyphenated techniques. [15][16][17] Analytical techniques used in the determination of phenol impurities are mainly liquid chromatography (LC), 18 capillary electrophoresis (CE), [19][20][21][22] and gas chromatography (GC) with mass spectrometry.…”

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confidence: 99%

Development and Validation of a Sensitive and Fast Solid-phase Spectrophotometric Procedure for Phenol Determination in Pharmaceuticals

et al. 2012

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A very sensitive, simple, and fast solid-phase spectrophotometric procedure for the determination of phenol using the p-nitrobenzenediazonium reagent (DAR reagent) was developed. This procedure is based on the simultaneous concentration of the orange product on a Dowex 1-X2 anion exchanger within 15 min, and a direct absorbance measurement of the sorbed species at both 530 nm (the absorption maximum of the phenol-DAR in the resin phase) and 700 nm (the range where only the resin absorbs light). Quality control and evaluation of the analytical parameters was carried out using a comprehensive prevalidation strategy. The linearity of the method was confirmed within an analyte working range from 0.01 to 0.10 μmol (0.2 to 2.0 nmol mL -1 ). The precision ranged from ±1.17 to ±9.61%; the accuracy ranged from -17.50 to +17.81%. The evaluated limiting values were LD = 0.0013 μmol and LQ = 0.0082 μmol. The DAR-SPS method was successfully applied to the determination of phenol in a pharmaceutical sample of salicylic acid (98.0 -100.0%) and vaccines (98.0 -103.4%).

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“…Several papers (2)(3)(4)(5)(6)(7) suggested that the reaction product was a pquinoneimide and that the reaction could not proceed when the position para-to OH was occupied by alkyl, aryl, nitroso, nitro, benzoyl, ester, or aldehyde groups but would take place when that position was substituted by halo, carbonyl, alkoxyl, and sulfonic acid groups. It was reported (6) that although the colour reaction did not occur with certain p-substituted phenols, a white reaction product could be isolated and this material was purported to be the result of an ortho coupling process.…”

Section: Introductionmentioning

confidence: 99%

Structures of the pyrazolones formed by oxidative coupling of phenols with 4-aminoantipyrine

Barton¹,

Johnson²,

Robertson³

et al. 1987

Can. J. Chem.

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. 2082 (1987). 65,The structures of reaction products between 4-amino-2,3-dimethyl-l-phenyl-3-pyrazolin-5-one and o-cresol, p-cresol, and p-ethylphenol are reported. The reaction of the former compound with phenols is used to estimate the concentration of phenol in 65, 2082 (1987).On a dCterminC les structures des produits de la rCaction de l'amino-4 dimethyl-2,3 phCnyl-1 pyrazoline-3 one-5 avec 1'0-crksol, le p-crtsol et le p-CthylphCnol. On utilise la rCaction de ce produit hCtCrocyclique avec les phCnols pour dtterminer la concentration des phtnols dans les sources d'eau potable. Les produits de la rkaction sont respectivement la dimethyl- [Traduit par la revue]

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Farbreaktion von Phenolen mit 4-Aminoantipyrin I. Untersuchung der Eigenschaften des Farbproduktes und der Reaktionsbedingungen

Cited by 27 publications

References 0 publications

A Sensitive Spectrophotometric Method for Determination of Diosmin Using Sodium Nitroprusside as a Chromogenic Reagent

A Sensitive Spectrophotometric Method for Determination of Diosmin Using Sodium Nitroprusside as a Chromogenic Reagent

Development and Validation of a Sensitive and Fast Solid-phase Spectrophotometric Procedure for Phenol Determination in Pharmaceuticals

Structures of the pyrazolones formed by oxidative coupling of phenols with 4-aminoantipyrine

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