Fanconi's anemia as a nature's evolutionary experiment on carcinogenesis.

Fanconi Anemia Is Characterized by Delayed Repair Kinetics of DNA Double-Strand Breaks

“…Fanconi anemia (FA) is a rare recessive disorder characterized by diverse developmental abnormalities, progressive bone marrow failure (BMF) and predisposition to both hematological malignancies and solid tumors (Okuyama and Mishina 1987). The hallmark of the FA cellular phenotype is sensitivity to DNA cross-linking agents such as mitomycin C (Sasaki and Tonomura 1973) and diepoxybutane (DEB) (Auerbach and Wolman 1976;Auerbach et al 2003).…”