2010
DOI: 10.1620/tjem.221.69
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Fanconi Anemia Is Characterized by Delayed Repair Kinetics of DNA Double-Strand Breaks

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Cited by 15 publications
(7 citation statements)
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“…First, there is a delay in the disappearance of γ-H2AX foci induced by cisplatin or IR in cells treated with FAN1 siRNA compared with control cells. Similar results were reported recently in FA cells (Leskovac et al, 2010). At all time points during recovery from cisplatin and IR, there are more RAD51 foci in FAN1-depleted cells than in control cells (Figure 7C).…”
Section: Discussionsupporting
confidence: 93%
“…First, there is a delay in the disappearance of γ-H2AX foci induced by cisplatin or IR in cells treated with FAN1 siRNA compared with control cells. Similar results were reported recently in FA cells (Leskovac et al, 2010). At all time points during recovery from cisplatin and IR, there are more RAD51 foci in FAN1-depleted cells than in control cells (Figure 7C).…”
Section: Discussionsupporting
confidence: 93%
“…The repair kinetics of radiation-induced DSBs were assessed in primary fibroblasts from Fanconi anemia, non-fanconic anemia bone marrow failure (non-FABMF) and control cell lines based on a gH2AX assay. Twenty-four hours after exposure to 2 Gy of IR, the level of gH2AX foci per cell in Fanconi anemia cell lines was approximately 2.5-fold higher compared to that in non-FABMF patients, and approximately 8-fold higher when compared with non-irradiated controls [103]. Fanconi anemia fibroblasts retained an elevated level of residual gH2AX foci after 24 h IR exposure, suggesting that the persistence of gH2AX foci could be a reliable measure to diagnose Fanconi anemia from non-FABMF and controls.…”
Section: Fibroblastsmentioning
confidence: 88%
“…The assay has already successfully identified AT, NBS, xeroderma pigmentosum, FA, retinoblastoma, Ligase IV syndrome patients and others [114; 119; 120; 121; 122]. Recently, the new translational opportunities of the γ-H2AX assay attracted attention of several international groups, but the reported results are somewhat contradictory.…”
Section: Individual Radiosensitivitymentioning
confidence: 99%