Family structure and alcohol use disorder: a register‐based cohort study among offspring with and without parental alcohol use disorder

Holst, Charlotte; Tolstrup, Janne S; Sørensen, Holger J.; Becker, Ulrik

doi:10.1111/add.14932

Cited by 16 publications

(15 citation statements)

References 68 publications

(82 reference statements)

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“…the individual's own alcohol consumption or of paternal AUD. This corroborates recent findings from a Danish register-based study suggesting that children from non-intact family structures have an increased risk of developing alcohol problems regardless of parental AUD [44]. We found that 30% of participants had reported institutionalization at the individual level and the association with developing AD later in life may reflect a wide range of underlying factors.…”

Section: Main Findingssupporting

confidence: 91%

“…Individuals at 'low risk' could have had fathers (or mothers) with unregistered AUD or were diagnosed before the national health registers were computerized in 1969 and 1977, respectively. Also, strict matching on socio-demographic background characteristics to families in which the father had AUD could have implied that low-risk controls were exposed to environmental factors such as family disruption, which appear to increase the risk of developing AUD independently of parental history of AUD [28,44].…”

Section: Main Findingsmentioning

confidence: 99%

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Young adult predictors of alcohol dependence to age 53: a 44‐year prospective cohort study of Danish men

et al. 2020

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Aims To examine if (1) there is a positive association between drinking volume in young men and life‐time risk of alcohol dependence (AD) and (2) there are other associations between young adulthood factors and life‐time risk of AD. Design Prospective cohort study of sons of fathers with alcohol use disorder (AUD) and matched low‐risk controls without paternal AUD. Setting and participants A total of 204 men, who were assessed at baseline in 1979 at age 19–20 years, were followed through record linkage with Danish registers and consecutive psychiatric interviews at the ages of 33, 43 and 53 years. Measurements AD diagnoses were interview‐based according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd edition, or made by treating clinicians according to the International Classification of Diseases (ICD) revision 8 (ICD‐8) until 1993 and revision 10 (ICD‐10) from 1994.We estimated odds ratios (ORs) with 95% confidence intervals (CI) for the development of AD after adjustment for confounders including smoking, social status and paternal AUD. Findings The following variables from the examination at age 19–20 independently predicted life‐time AD: alcohol consumption > 21 beverages/week versus 0–21 [odds ratio (OR) = 2.46, 95% confidence interval (CI) = 1.22–4.97], police contact (OR = 2.60, 95% CI = 1.28–5.28) and institutionalization related to the individual (OR = 2.90, 95% CI = 1.39–6.02). Compared with < 1 beverages/week, the risk for AD did not increase significantly for drinking volume categories: 1–7, 8–14 or 15–21 beverages/week. Conclusion Independently of other risk factors in young adulthood, young Danish men's risk for life‐time alcohol dependence appears to be predicted by a drinking volume at age 19–20 years exceeding 21 beverages per week.

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Section: Main Findingssupporting

confidence: 91%

Section: Main Findingsmentioning

confidence: 99%

Young adult predictors of alcohol dependence to age 53: a 44‐year prospective cohort study of Danish men

et al. 2020

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“…Approximately two-thirds of mothers but only one-third of fathers with a hospital diagnosis of substance abuse (including but not limited to alcohol abuse) live with their children [ 45 ]. AUD can also disrupt family structures, and it is more common for children of parents with AUD than children of parents without AUD to grow up with only one or neither of their parents [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Mortality in adult children of parents with alcohol use disorder: a nationwide register study

et al. 2022

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Research suggests that adult children of parents with harmful alcohol use are at increased risk for premature death. This national cohort study investigated mortality in adult children of parents with alcohol use disorder (AUD), adjusting for sociodemographic variables. The study used 1973 to 2018 data from Swedish national registers to compare mortality risk in children who had ≥ 1 parent with AUD (ICD-10 code F10 and its ICD-8 and ICD-9 equivalents) (n = 122,947) and those who did not (n = 2,298,532). A Cox regression model adjusted for year of birth, sex, parental education, and childhood loss of a parent was used. Before the age of 18 years, about 5% of children born in Sweden lived with ≥ 1 parent who had a clinical diagnosis of AUD. Overall mortality was higher in adult children of parents with AUD: hazard ratio (HR) 1.76, 95% confidence interval (CI) 1.71–1.82. Mortality remained elevated after adjustments for sociodemographic factors (HR 1.45, 95% CI 1.40–1.50). Children of parents with AUD had increased mortality from all investigated causes. The highest excess risk was for death from drug-related causes (excluding accidental poisonings) (HR 3.08, 95% CI 2.74–3.46). For most causes, mortality was higher if the mother had AUD than if the father had AUD. Patterns of mortality were similar in both sexes. This study provides evidence that parental AUD raises the risk of offspring mortality from preventable causes such as drug use, suicide (HR 2.16, 95% CI 1.98–2.36), accident (HR 2.00, 95% CI 1.87–2.13), and assault (HR 1.76, 95% CI 1.38–2.24).

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“…For example, heavy drinking, the dominant cause of cirrhosis in Denmark, is associated with an increased likelihood of living alone and with low social support. [10] , [11] , [12] , [13] Further, individuals with weak social relationships have a lower adherence with medical treatments. 14 , 15 Therefore, individuals with cirrhosis who have weak social relationships may be particularly vulnerable and have a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Social support and risk of mortality in cirrhosis: A cohort study

Askgaard¹,

Madsen²,

Wowern³

et al. 2023

JHEP Reports

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Family structure and alcohol use disorder: a register‐based cohort study among offspring with and without parental alcohol use disorder

Abstract: Aims: To assess whether parental alcohol use disorder (AUD) is associated with higher risks of living in a non-intact family and assess whether non-intact family structure is associated with higher risks of AUD in the offspring.

Cited by 16 publications

References 68 publications

Young adult predictors of alcohol dependence to age 53: a 44‐year prospective cohort study of Danish men

Young adult predictors of alcohol dependence to age 53: a 44‐year prospective cohort study of Danish men

Mortality in adult children of parents with alcohol use disorder: a nationwide register study

Social support and risk of mortality in cirrhosis: A cohort study

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