Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

Dijk, D. A. van; Oostindiër, M.J.; Kloosterman-Boele, W.M.; Krijnen, Pieta; Vasen, Hans F. A.

doi:10.1007/s10689-006-9114-8

Cited by 46 publications

(44 citation statements)

References 13 publications

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“…The minimum information that should be collected is the size of the family and the number of first-degree relatives (and second-degree relatives if a first-degree relative is affected) with cancer, type of cancer and age at diagnosis [12]. In order to improve the quality of family history taking, more attention should be given to cancer genetics in the curriculum of medical doctors.…”

Section: Discussionmentioning

confidence: 99%

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

et al. 2009

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Familial colorectal cancer (CRC) accounts for 10-15% of all CRCs. In about 5% of all cases, CRC is associated with a highly penetrant dominant inherited syndrome. The most common inherited form of non-polyposis CRC is the Lynch syndrome which is responsible for about 2-4% of all cases. Surveillance of individuals at high risk for CRC prevents the development of advanced CRC. About 1 million individuals in Western Europe are at risk for Lynch syndrome. We performed a survey to evaluate the strategies currently used to identify individuals at high risk for CRC in 14 Western European countries. Questionnaires were distributed amongst members of a European collaborative group of experts that aims to improve the prognosis of families with hereditary CRC. The survey showed that in all countries obtaining a family history followed by referral to clinical genetics centres of suspected cases was the main strategy to identify familial and hereditary CRC. In five out of seven countries with a (regional or national) CRC population screening program, attention was paid in the program to the detection of familial CRC. In only one country were special campaigns organized to increase the awareness of familial CRC among the general population. In almost all countries, the family history is assessed when a patient visits a general practitioner or hospital. However, the quality of family history taking was felt to be rather poor. Microsatellite instability testing (MSI) or immunohistochemical analysis (IHC) of CRC are usually recommended as tools to select high-risk patients for genetic testing and are performed in most countries in patients suspected of Lynch syndrome. In one country, IHC was recommended in all new cases of CRC. In most countries there are no specific programs on cancer genetics in the teaching curriculum for medical doctors. In conclusion, the outcome of this survey and the discussions within an European expert group may be used to improve the strategies to identify individuals at high risk of CRC. More attention should be given to increasing the awareness of the general population of hereditary CRC. Immunohistochemical analysis or MSI-analysis of all CRCs may be an effective tool for identifying all Lynch syndrome families. The cost-effectiveness of this approach should be further evaluated. All countries with a CRC population screening program should obtain a full family history as part of patient assessment.

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Section: Discussionmentioning

confidence: 99%

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

et al. 2009

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“…Lynch syndrome is the most common inherited form of CRC, and can account for 1-5% of all CRC [20][21][22][23]. Unlike FAP it does not have an easily recognizable intestinal phenotype, and thus its diagnosis relies on the analysis of clinical and pathological features of the disease, present in the Amsterdam and Bethesda criteria [19,22].…”

Section: Discussionmentioning

confidence: 99%

“…For families with clustering of CRC but without evidence of MSI colonoscopy should start 5-10 years younger than the earliest colon cancer diagnosis in the family and be repeated every 3-5 years [22]. In a recent study conducted in The Netherlands, Van Dijk et al [23] investigated CRC patients diagnosed before age 50 or with multiple primary tumors, and found that family history is neglected in the work-up of the majority of these patients [23]. Our study points out a similar result.…”

Section: Discussionmentioning

confidence: 99%

Family history of cancer in Brazil: is it being used?

et al. 2008

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In developing countries, low budgets make the issue of integrating genetics into clinical practice a challenge, a situation in which the use of family history (FH) becomes important for patient care, as it is a low cost strategy and a risk assessment tool. The purpose of this study was to review medical records of patients with colorectal cancer (CRC) seen in a public University Hospital and evaluate how often FH of cancer is registered. Initially we searched a database for patients who were seen in our hospital between 2002 and 2004 with the diagnosis of CRC. We found 415 patients, 104 of whom were excluded. A total of 311 charts were reviewed and classified into 3 groups. Group A: no FH documented; group B: FH was documented, but FH of cancer was not collected; and group C: FH of cancer was documented. We also investigated what type of information was recorded, in order to verify if important elements were assessed. Ninety-eight charts (31.5%) were classified in group A, 20 (6.5%) in group B, and 193 (62%) in group C. In addition, we observed that important information regarding affected relatives was not collected in most of the charts. In conclusion, we found that although FH of cancer was recorded in 62% of charts of patients with CRC, information that could be relevant for risk assessment and management of at-risk families was missing. Our findings expose an important problem in health education that could reflect negatively in the quality of medical assistance to individuals at risk for familial cancer.

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“…Despite the impact that diagnosing hereditary CRC syndromes may have on the patient and their family, these syndromes often go unrecognized in surgical clinics because of inadequate family cancer history taking, lack of time for assessment, and/or lack of knowledge regarding these syndromes. 5,6 the aim of this study was to assess the efficacy of a hereditary CRC registry in identifying ls in patients with newly diagnosed CRC seen in a colorectal surgical clinic.…”

Section: Increasing Lynch Syndrome Identification Through Establishmementioning

confidence: 99%

Increasing Lynch Syndrome Identification Through Establishment of a Hereditary Colorectal Cancer Registry

Sturgeon

McCutcheon

Geiger

et al. 2013

Diseases of the Colon &Amp; Rectum

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Family history is neglected in the work-up of patients with colorectal cancer: a quality assessment using cancer registry data

Cited by 46 publications

References 13 publications

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

Recommendations to improve identification of hereditary and familial colorectal cancer in Europe

Family history of cancer in Brazil: is it being used?

Increasing Lynch Syndrome Identification Through Establishment of a Hereditary Colorectal Cancer Registry

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