“…44 In addition, family history is relevant for subclinical disease, such as coronary artery calcification 45,46 and the risk of sudden death during an acute coronary event. 47 As with type 2 diabetes, GWAS has uncovered dozens of loci that are associated with increased risk of coronary artery disease. 48 One marker, at chromosomal locus 9p21, has garnered considerable attention because of its effect in multiple ethnic groups, the reproducibility of the finding in almost every study, and the infinitesimally small p value of the combined statistical strength of association.…”