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Cited by 224 publications
(416 citation statements)
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References 635 publications
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“…We speculate that the worse prognosis in IHD is inherent in the double burden of disease. As one of the pathogenic causes of HF, the presence of IHD may not only be causally responsible for myocardial damage and adverse cardiac remodelling but also related to or involved in other pathological mechanisms, such as progressive inflammatory and circulatory compromising conditions and unstable electrical substrates capable of initiating and sustaining arrhythmias . If the underlying pathological mechanisms are ongoing, the increased risk of mortality will likely remain.…”
Section: Discussionmentioning
confidence: 99%
“…We speculate that the worse prognosis in IHD is inherent in the double burden of disease. As one of the pathogenic causes of HF, the presence of IHD may not only be causally responsible for myocardial damage and adverse cardiac remodelling but also related to or involved in other pathological mechanisms, such as progressive inflammatory and circulatory compromising conditions and unstable electrical substrates capable of initiating and sustaining arrhythmias . If the underlying pathological mechanisms are ongoing, the increased risk of mortality will likely remain.…”
Section: Discussionmentioning
confidence: 99%
“…10 Before initiation of treatment, 13(38%) patients had experienced syncope, 4(12%) had aborted cardiac arrest and 1(3%) had a documented ventricular arrhythmia. During treatment with beta-1 selective beta blockers, 3(11%) patients had syncope including 1(4%) that also had an appropriate ICD shock (non adherent to therapy).…”
Section: Clinical Characteristicsmentioning
confidence: 99%
“…In the new guidelines, beta blocker therapy is a class IC recommendation in clinically diagnosed CPVT patients, and should also be considered in genotype positive, phenotype negative family members (class IIa C). 10 Beta blockers are suggested to provide arrhythmia protection by reducing the influence of catecholamines 11 by blocking the beta receptor induced intracellular signaling which leads to destabilization of RyR2. However, beta blockers differ in many aspects, including selectivity, half life, lipid solubility and bio availability, and 6 limited data exist on how anti arrhythmic effects differ in specific beta blockers.…”
Section: Introductionmentioning
confidence: 99%
“…Current guidelines recommend ICD implantation in patients with DCM who have a reasonable life expectancy and quality of life and either: 1) a history of ventricular arrhythmia with hemodynamic compromise (secondary prevention); or 2) New York Heart Association functional class II/III symptoms and LVEF #35%, despite optimal medical therapy (primary prevention)(15,18). However, ICDs are moderately expensive, do not improve quality of life, and entail a significant risk of morbidity.…”
mentioning
confidence: 97%
“…Thus, evaluation for ICD requires an individualized assessment of the potential risks and benefits.PREDICTION OF LV FUNCTIONAL RECOVERY.Approximately one-third of DCM patients may experience partial or complete recovery with medical treatment, which, in turn, is associated with a favorable prognosis(41). Patients should therefore receive at least 3 months of optimal medical therapy prior to formal evaluation for an ICD(15,18), but LV functional recovery may continue well beyond this point, leading to a risk of unnecessary implantation. By informing the likelihood of reverse remodeling, LGE-CMR could help to optimize ICD deployment, identifying patients with high remodeling potential who may warrant lengthier periods of treatment before ICD decision-making.…”
mentioning
confidence: 99%